Title:Concise Review on Scientific Approaches to Burns and Scars
Volume: 19
Issue: 2
Author(s): Hitesh Malhotra, Prerna Sharma*, Mohammad Amjad Kamal, Peeyush Kaushik and Nidhi Rani*
Affiliation:
- Department of Pharmaceutical Science, Guru Gobind Singh College of Pharmacy, Yamuna Nagar (Haryana), India
- Chitkara College of Pharmacy, Chitkara University, Punjab, India
Keywords:
Burns, clinical, infections, pre-clinical, scar, wound, healing processes.
Abstract: Burns are large open surgical lesions bathed in virulent pus that result in rupturing of the
cutaneous membrane, which has serious consequences such as an extensive loss of proteins, and
body fluids, increased chances of infections, and sometimes death. These can be classified based
on their penetration levels, i.e., first-degree burns penetrating the epidermis, second-degree burns
including both epidermis and dermis, third-degree burns to both layers including the hair follicular
cells, sweat glands and various core tissues, fourth-degree burns to adipose tissue, fifth stage burns
to muscles, and sixth stage burns to bones. Wound healing/wound repair is a very perplexing process
in which the tissues of the affected/burnt area repairs themselves to attain their original form
and functionality but develop a scar at the wound site. This article mainly focuses on the algorithms
to differentiate various degrees of burns, general first aid approaches to burns and scars, the
rationale of treatment of burns, basic mechanisms highlighting the healing processes in humans in
terms of free from scar formation as well as with scar formation at their elementary levels including
cellular as well as biochemical levels, utility, and progression of pre-clinical data to humans
and finally approaches for the improvement of scar formation in man.
