Title:Computer Tomography (CT)-based Screening of Hospitalized Patients with
Chronic Obstructive Pulmonary Disease Complicated by Bronchiectasis
Phenotype during Acute Exacerbation: A Clinical Analysis
Volume: 20
Author(s): Jingmei Zhao*, Yiping Wu*, Kai Zhang, Hongfeng Zhang, Hongbo Ren and Yonghong Wang
Affiliation:
- Handan Central Hospital, Hanshan District, Handan, Hebei Province, China
- Handan Central Hospital, Hanshan District, Handan, Hebei Province, China
Keywords:
Acute exacerbation, Chronic obstructive, Pulmonary disease, Moderate to severe, Nutritional risk screening, Nutritional status.
Abstract:
Background:
In the past, many experts considered chronic obstructive pulmonary disease (COPD) and bronchiectasis to be separate, chronic respiratory
diseases. Nonetheless, the widespread use of high-resolution lung computed tomography (CT) has led to the discovery that these diseases can occur
alone or together.
Aim:
The current study aimed to compare the effects of nutritional status on the clinical outcomes in moderate to severe COPD patients with
bronchiectasis.
Objective:
This study identifies the nutritional risk in hospitalized patients with moderate to severe COPD complicated by bronchiectasis phenotype during
acute exacerbation screened using computer tomography (CT). Also, determines its correlation with disease progression.
Materials and Methods:
NRS 2002 (Nutrition Risk Screening Evaluation Tool) was used to determine and evaluate the nutritional risk status in 182 hospitalized patients
with moderate to severe COPD complicated by bronchiectasis phenotype during an acute exacerbation. Selected patients were divided into the
nutritional risk (NR) group and the non-nutritional risk (NNR) group according to their nutritional status determined by NRS 2002. The body mass
index (BMI), serum albumin (ALB), pre albumin (PAB), lymphocyte count (TLC), FEV1/FVC, FEV1% predicted, PEF% predicted, blood gas
analysis, number of acute exacerbations in the past year, number of respiratory failure cases, number of anti-infection days, and length of
hospitalization of the two groups were observed.
Results:
The hospitalized patients in acute exacerbation of moderate to severe COPD complicated by bronchiectasis phenotype had a nutritional risk of
62.64%. BMI, ALB, PAB, TLC, FEV1% predicted, FEV1/FVC, PEF% predicted, blood gas analysis, number of acute exacerbations in the past
year, number of respiratory failure cases, number of anti-infection days, and length of hospitalization were statistically significantly different
between the NR group and NNR group (P<0.05).
Conclusion:
Hospitalized patients with moderate to severe COPD complicated by bronchiectasis phenotype during acute exacerbation are often associated with
nutritional risk. An increase in nutritional risk reduces the level of pulmonary function of the patient and elevates the risk for repeated acute
exacerbations, which predispose the patient to respiratory failure, thereby increasing the length of hospitalization. Therefore, the nutritional risk
status of COPD patients with bronchiectasis was closely related to the occurrence, development, and prognosis of the disease.
