Title:Cholinergic Transporters Serve as Potential Targets in Alzheimer’s
Disease
Volume: 24
Issue: 4
Author(s): Renu Bist*D.K. Bhatt
Affiliation:
- Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, 302004, India
Keywords:
Acetylcholine, transporters, vesicular acetylcholine transporter (VAChT), Alzheimer's disease, nerve growth factor (NGF), dementia.
Abstract: Alzheimer's disease (AD) is a specific brain disease that gradually worsens
due to dementia over a long period. AD accounts for almost 60% to 80% of cases of
dementia. Any damage to neurons affects their ability to communicate, leading to
alteration in thinking, behaviour and feelings. Besides mental, motor abilities of an
individual may also be affected due to AD. Therefore, it is cardinal to understand the key
mechanisms by which either AD progression can be ceased or, after the onset of the
disease it could be reverted. Both of these steps need the identification of a particular
receptor or a molecular marker through which a drug can enter the neurons. Cholinergic
transporters are such potential targets of AD, which regulate the movement of
acetylcholine and thus regulate the nerve impulse conduction in the brain. The current
article entails information regarding a variety of cholinergic transporters, which will
provide a research gap to the global scientific community.
