Title:Mechanistic Role of Tempol: Synthesis, Catalysed Reactions and
Therapeutic Potential
Volume: 19
Issue: 9
Author(s): Abhishek Tiwari*, Varsha Tiwari, Bimal Krishna Banik and Biswa Mohan Sahoo
Affiliation:
- Department of Pharmacy, Pharmacy Academy, IFTM University, Lodhipur-Rajpur, Moradabad, 244102 India
Keywords:
Superoxide dismutase, COVID-19, Radical capturing, RNA-dependent, RNA polymerase, fibrocystic diseases, Cardioprotective.
Abstract: Tempol (TP) was introduced in 1960 by Lebedev and Kazarnovskii and is an excellent
catalyst extensively used in the synthesis and oxidation of various reagents. 4-Hydroxy-2,2,6,6-
tetramethylpiperidin-1-oxyl (TP) has also been explored against various disorders like inflammation,
superoxide anion-influenced molecular linked behavioural modifications, radical capturing, cardioprotective,
protective ocular damage, against skin burns, fibrocystic diseases, breast cancer prevention,
respiratory infections, alopecia, and cerebral malaria, etc. This review article comprises five
major aspects of TP namely (a) Approx. 25 different Synthesis schemes of TP (b) major reactions
catalysed by TP (c) Therapeutic potential of TP. It also provides scientific information that supports
the use of TP which may be proven as a “MIRACLE” drug for the treatment of numerous disorders
namely in reducing the reactive oxygen species, superoxide mutases, vision disorders, cancer as well
as in covid. It also possesses a significant role in minimising side effects in combination therapy.
This review will be beneficial to researchers, healthcare, and academic professionals for further
research.