Quercetin: A Comprehensive Review

Dharmendra      Kumar; Pramod   Kumar   Sharma
doi:10.2174/1573401319666230428152045
Abstract

Quercetin is a plant pigment found in many fruits, vegetables, beverages, and other parts of plants, such as leaves, flowers, bark, stems, and roots. The rich sources of quercetin are the dock, watercress, sweet potato, onion, grapes, berries, cherries, and broccoli. Quercetin exhibits various pharmacological activities, such as anticancer, antiviral, anti-inflammatory, and antioxidant. Several studies have reported quercetin as a potential anticancer compound. This review article provides information on the role of quercetin in many types of cancer, such as breast cancer, colon cancer, liver cancer, lung cancer, prostate cancer, bladder cancer, gastric cancer, bone cancer, blood cancer, brain cancer, cervical cancer, head and neck cancer, skin cancer, eye cancer, thyroid cancer, ovarian cancer, kidney cancer, and mesothelioma cancer. The present review emphasizes the anticancer activity of quercetin via different mechanisms, such as induced apoptosis, inhibition of tumor progression, cancer cell cycle arrest via different pathways, decreased proliferation, modification of the tumor microenvironment, etc.
Keywords: Quercetin, anticancer activity, source of quercetin, mechanism of cancer treatment, eye cancer, colon cancer.
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Graphical Abstract

[1]
Benavente-García O, Castillo J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem  2008; 56(15): 6185-205.
 [http://dx.doi.org/10.1021/jf8006568] [PMID: 18593176]

[2]
Kandaswami C, Lee LT, Lee PP, et al. The antitumor activities of flavonoids. In vivo  2005; 19(5): 895-909.
 [PMID: 16097445]

[3]
93 Quercetin rich foods ranked by quercetin density.  Available from: https://myintakepro.com/blog/quercetinrich-foods

[4]
Iacopetta D, Grande F, Caruso A, et al. New insights for the use of quercetin analogs in cancer treatment. Future Med Chem  2017; 9(17): 2011-28.
 [http://dx.doi.org/10.4155/fmc-2017-0118] [PMID: 29076772]

[5]
Liu Y, Tang ZG, Lin Y, et al. Effects of quercetin on proliferation and migration of human glioblastoma U251 cells. Biomed Pharmacother  2017; 92: 33-8.
 [http://dx.doi.org/10.1016/j.biopha.2017.05.044] [PMID: 28528183]

[6]
Batiha GES, Beshbishy AM, Ikram M, et al. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods  2020; 9(3): 374.
 [http://dx.doi.org/10.3390/foods9030374] [PMID: 32210182]

[7]
Murakami A, Ashida H, Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett  2008; 269(2): 315-25.
 [http://dx.doi.org/10.1016/j.canlet.2008.03.046] [PMID: 18467024]

[8]
Shih H, Pickwell GV, Quattrochi LC. Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer. Arch Biochem Biophys  2000; 373(1): 287-94.
 [http://dx.doi.org/10.1006/abbi.1999.1550] [PMID: 10620351]

[9]
Brito A, Ribeiro M, Abrantes A, et al. Quercetin in cancer treatment, alone or in combination with conventional therapeutics? Curr Med Chem  2015; 22(26): 3025-39.
 [http://dx.doi.org/10.2174/0929867322666150812145435] [PMID: 26264923]

[10]
Abarikwu SO, Pant AB, Farombi EO. Dietary antioxidant, quercetin, protects sertoli-germ cell coculture from atrazine-induced oxidative damage. J Biochem Mol Toxicol  2012; 26(11): 477-85.
 [http://dx.doi.org/10.1002/jbt.21449] [PMID: 23132811]

[11]
Nabavi SF, Nabavi SM, Mirzaei M, Moghaddam AH. Protective effect of quercetin against sodium fluoride induced oxidative stress in rat’s heart. Food Funct  2012; 3(4): 437-41.
 [http://dx.doi.org/10.1039/c2fo10264a] [PMID: 22314573]

[12]
Seyed MA, Jantan I, Bukhari SNA, Vijayaraghavan K. A comprehensive review on the chemotherapeutic potential of piceatannol for cancer treatment, with mechanistic insights. J Agric Food Chem  2016; 64(4): 725-37.
 [http://dx.doi.org/10.1021/acs.jafc.5b05993] [PMID: 26758628]

[13]
de Martel C, Ferlay J, Franceschi S, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol  2012; 13(6): 607-15.
 [http://dx.doi.org/10.1016/S1470-2045(12)70137-7] [PMID: 22575588]

[14]
Martin KR. Targeting apoptosis with dietary bioactive agents. Exp Biol Med  2006; 231(2): 117-29.
 [http://dx.doi.org/10.1177/153537020623100201] [PMID: 16446487]

[15]
Nguyen LT, Lee YH, Sharma AR, et al. Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity. Korean J Physiol Pharmacol  2017; 21(2): 205-13.
 [http://dx.doi.org/10.4196/kjpp.2017.21.2.205] [PMID: 28280414]

[16]
Minaei A, Sabzichi M, Ramezani F, Hamishehkar H, Samadi N. Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells. Mol Biol Rep  2016; 43(2): 99-105.
 [http://dx.doi.org/10.1007/s11033-016-3942-x] [PMID: 26748999]

[17]
Srinivasan A, Thangavel C, Liu Y, et al. Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer. Mol Carcinog  2016; 55(5): 743-56.
 [http://dx.doi.org/10.1002/mc.22318] [PMID: 25968914]

[18]
Balakrishnan S, Bhat FA, Raja Singh P, et al. Gold nanoparticleconjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2-mediated pathway in breast cancer. Cell Prolif  2016; 49(6): 678-97.
 [http://dx.doi.org/10.1111/cpr.12296] [PMID: 27641938]

[19]
Sarkar A, Ghosh S, Chowdhury S, Pandey B, Sil PC. Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells. Biochim Biophys Acta, Gen Subj  2016; 1860(10): 2065-75.
 [http://dx.doi.org/10.1016/j.bbagen.2016.07.001] [PMID: 27392941]

[20]
Seo HS, Ku JM, Choi HS, et al. Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells. Oncol Rep  2016; 36(1): 31-42.
 [http://dx.doi.org/10.3892/or.2016.4786] [PMID: 27175602]

[21]
Lv L, Liu C, Chen C, et al. Quercetin and doxorubicin coencapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer. Oncotarget  2016; 7(22): 32184-99.
 [http://dx.doi.org/10.18632/oncotarget.8607] [PMID: 27058756]

[22]
Wang R, Yang L, Li S, et al. Quercetin inhibits breast cancer stem cells via downregulation of aldehyde dehydrogenase 1A1 (ALDH1A1), chemokine receptor type 4 (CXCR4), mucin 1 (MUC1), and epithelial cell adhesion molecule (EpCAM). Med Sci Monit  2018; 24: 412-20.
 [http://dx.doi.org/10.12659/MSM.908022] [PMID: 29353288]

[23]
Kundur S, Prayag A, Selvakumar P, et al. Synergistic anticancer action of quercetin and curcumin against triple negative breast cancer cell lines. J Cell Physiol  2019; 234(7): 11103-18.
 [http://dx.doi.org/10.1002/jcp.27761] [PMID: 30478904]

[24]
Niazvand F, Orazizadeh M, Khorsandi L, Abbaspour M, Mansouri E, Khodadadi A. effects of quercetin-loaded nanoparticles on MCF-7 human breast cancer cells. Medicina  2019; 55(4): 114.
 [http://dx.doi.org/10.3390/medicina55040114] [PMID: 31013662]

[25]
Kee JY, Han YH, Kim DS, et al. Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of metastatic ability. Phytomedicine  2016; 23(13): 1680-90.
 [http://dx.doi.org/10.1016/j.phymed.2016.09.011] [PMID: 27823633]

[26]
Zhao Y, Fan D, Zheng ZP, et al. 8- C -(E -phenylethenyl)quercetin from onion/beef soup induces autophagic cell death in colon cancer cells through ERK activation. Mol Nutr Food Res  2017; 61(2): 1600437.
 [http://dx.doi.org/10.1002/mnfr.201600437] [PMID: 27670274]

[27]
Song Y, Han M, Zhang X. Quercetin suppresses the migration and invasion in human colon cancer Caco-2 cells through regulating	toll-like receptor 4/Nuclear Factor-kappa B pathway. Pharmacogn	Mag 2016; 12(46)(S2): 237.
 [http://dx.doi.org/10.4103/0973-1296.182154] [PMID: 27279714]

[28]
Pang B, Xu X, Lu Y, et al. Prediction of new targets and mechanisms for quercetin in the treatment of pancreatic cancer, colon cancer, and rectal cancer. Food Funct  2019; 10(9): 5339-49.
 [http://dx.doi.org/10.1039/C9FO01168D] [PMID: 31393490]

[29]
Kim JH, Kim MJ, Choi KC, Son J. Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover. Int J Biochem Cell Biol  2016; 78: 327-34.
 [http://dx.doi.org/10.1016/j.biocel.2016.07.033] [PMID: 27477310]

[30]
Nwaeburu CC, Bauer N, Zhao Z, et al. Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. Oncotarget  2016; 7(36): 58367-80.
 [http://dx.doi.org/10.18632/oncotarget.11122] [PMID: 27521217]

[31]
Cao C, Sun L, Mo W, et al. Quercetin mediates β catenin in pancreatic cancer stem like cells. Pancreas  2015; 44(8): 1334-9.
 [http://dx.doi.org/10.1097/MPA.0000000000000400] [PMID: 26284537]

[32]
Lee J, Han SI, Yun JH, Kim JH. Quercetin 3-O-glucoside suppresses epidermal growth factor-induced migration by inhibiting EGFR signaling in pancreatic cancer cells. Tumour Biol  2015; 36(12): 9385-93.
 [http://dx.doi.org/10.1007/s13277-015-3682-x] [PMID: 26109002]

[33]
Lee WJ, Hsiao M, Chang JL, et al. Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft. Arch Toxicol  2015; 89(7): 1103-17.
 [http://dx.doi.org/10.1007/s00204-014-1300-0] [PMID: 25138434]

[34]
Chen FY, Cao LF, Wan HX, et al. Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells. Mol Med Rep  2015; 11(1): 341-8.
 [http://dx.doi.org/10.3892/mmr.2014.2734] [PMID: 25339540]

[35]
Chen X, Dong XS, Gao HY, et al. Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells. Mol Med Rep  2016; 13(1): 689-96.
 [http://dx.doi.org/10.3892/mmr.2015.4600] [PMID: 26648539]

[36]
Guan X, Gao M, Xu H, et al. Quercetin-loaded poly (lactic- co -glycolic acid)- d -α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer. Drug Deliv  2016; 23(9): 3307-18.
 [http://dx.doi.org/10.1080/10717544.2016.1176087] [PMID: 27067032]

[37]
Maurya AK, Vinayak M. Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Mol Biol Rep  2015; 42(9): 1419-29.
 [http://dx.doi.org/10.1007/s11033-015-3921-7] [PMID: 26311153]

[38]
Bishayee K, Khuda-Bukhsh AR, Huh SO. PLGA Loaded gold nanoparticles precipitated with quercetin downregulate HDAC Akt activities controlling proliferation and activate p53 ROS crosstalk to induce apoptosis in hepatocarcinoma cells. Mol Cells  2015; 38(6): 518-27.
 [http://dx.doi.org/10.14348/molcells.2015.2339] [PMID: 25947292]

[39]
Wu L, Li J, Liu T, et al. Quercetin shows anti‐tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway. Cancer Med  2019; 8(10): 4806-20.
 [http://dx.doi.org/10.1002/cam4.2388] [PMID: 31273958]

[40]
Hisaka T, Sakai H, Sato T, et al. Quercetin suppresses proliferation of liver cancer cell lines in vitro. anticancer res 2020; 40(8): 4695-700.
 [http://dx.doi.org/10.21873/anticanres.14469] [PMID: 32727794]

[41]
Wu H, Pan L, Gao C, et al. Quercetin inhibits the proliferation of glycolysis-addicted HCC cells by reducing hexokinase 2 and AktmTOR pathway. molecules 2019; 24(10): 1993.
 [http://dx.doi.org/10.3390/molecules24101993] [PMID: 31137633]

[42]
Ren KW, Li YH, Wu G, et al. Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells. Int J Oncol  2017; 50(4): 1299-311.
 [http://dx.doi.org/10.3892/ijo.2017.3886] [PMID: 28259895]

[43]
Klimaszewska-Wiśniewska A, Hałas-Wiśniewska M, Izdebska M, Gagat M, Grzanka A, Grzanka D. Antiproliferative and antimetastatic action of quercetin on A549 non-small cell lung cancer cells through its effect on the cytoskeleton. Acta Histochem  2017; 119(2): 99-112.
 [http://dx.doi.org/10.1016/j.acthis.2016.11.003] [PMID: 27887793]

[44]
Xingyu Z, Peijie M, Dan P, et al. Quercetin suppresses lung cancer growth by targeting Aurora B kinase. Cancer Med  2016; 5(11): 3156-65.
 [http://dx.doi.org/10.1002/cam4.891] [PMID: 27704720]

[45]
Chuang CH, Yeh CL, Yeh SL, Lin ES, Wang LY, Wang YH. Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms. J Nutr Biochem  2016; 33: 45-53.
 [http://dx.doi.org/10.1016/j.jnutbio.2016.03.011] [PMID: 27260467]

[46]
Warnakulasuriya SN. Ziaullah, Rupasinghe HPV. Novel long chain fatty acid derivatives of quercetin-3-O-glucoside reduce cytotoxicity induced by cigarette smoke toxicants in human fetal lung fibroblasts. Eur J Pharmacol  2016; 781: 128-38.
 [http://dx.doi.org/10.1016/j.ejphar.2016.04.011] [PMID: 27071958]

[47]
Pratheeshkumar P, Son YO, Divya SP, et al. Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway. Oncotarget  2017; 8(32): 52118-31.
 [http://dx.doi.org/10.18632/oncotarget.10130] [PMID: 28881718]

[48]
Dong Y, Yang J, Yang L, Li P. Quercetin inhibits the proliferation and metastasis of human non-small cell lung cancer cell line: The key role of src-mediated fibroblast growth factor-inducible 14 (Fn14)/ nuclear factor kappa B (NF-κB) pathway. Med Sci Monit  2020; 26: e920537.
 [http://dx.doi.org/10.12659/MSM.920537] [PMID: 32225128]

[49]
Wang Q, Chen Y, Lu H, et al. Quercetin radiosensitizes non‐small cell lung cancer cells through the regulation of miR 16 5p/WEE1 axis. IUBMB Life  2020; 72(5): 1012-22.
 [http://dx.doi.org/10.1002/iub.2242] [PMID: 32027086]

[50]
Sharma V, Kumar L, Mohanty SK, Maikhuri JP, Rajender S, Gupta G. Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor – Synergistic action of quercetin and curcumin. Mol Cell Endocrinol  2016; 431: 12-23.
 [http://dx.doi.org/10.1016/j.mce.2016.04.024] [PMID: 27132804]

[51]
Wang P, Henning SM, Magyar CE, Elshimali Y, Heber D, Vadgama JV. Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy. J Exp Clin Cancer Res  2016; 35(1): 73.
 [http://dx.doi.org/10.1186/s13046-016-0351-x] [PMID: 27151407]

[52]
Wang Y, Zhang W, Lv Q, Zhang J, Zhu D. The critical role of quercetin in autophagy and apoptosis in HeLa cells. Tumour Biol  2016; 37(1): 925-9.
 [http://dx.doi.org/10.1007/s13277-015-3890-4] [PMID: 26260273]

[53]
Baruah MM, Khandwekar AP, Sharma N. Quercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastases. Tumour Biol  2016; 37(10): 14025-34.
 [http://dx.doi.org/10.1007/s13277-016-5277-6] [PMID: 27495232]

[54]
Lu X, Yang F, Chen D, et al. Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways. Int J Biol Sci  2020; 16(7): 1121-34.
 [http://dx.doi.org/10.7150/ijbs.41686] [PMID: 32174789]

[55]
Zhang X, Huang J, Yu C, et al. Quercetin enhanced paclitaxel therapeutic effects towards PC-3 prostate cancer through er stress induction and ROS production. OncoTargets Ther  2020; 13: 513-23.
 [http://dx.doi.org/10.2147/OTT.S228453] [PMID: 32021294]

[56]
Tummala R, Lou W, Gao AC, Nadiminty N. Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells. Mol Cancer Ther  2017; 16(12): 2770-9.
 [http://dx.doi.org/10.1158/1535-7163.MCT-17-0030] [PMID: 28729398]

[57]
Orsolic N, Karac I, Sirovina D, et al. Chemotherapeutic potential of quercetin on human bladder cancer cells. J Environ Sci Health  2016; 51: 776-81.

[58]
Alban L, Monteiro WF, Diz FM, et al. New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer. Mater Sci Eng C  2020; 110: 110662.
 [http://dx.doi.org/10.1016/j.msec.2020.110662] [PMID: 32204090]

[59]
Su Q, Peng M, Zhang Y, et al. Quercetin induces bladder cancer cells apoptosis by activation of AMPK signaling pathway. Am J Cancer Res  2016; 6(2): 498-508.
 [PMID: 27186419]

[60]
Tsai TF, Hwang TIS, Lin JF, Chen HE, Yang SC, Lin YC. Suppression of quercetin-induced autophagy enhances cytotoxicity through elevating apoptotic cell death in human bladder cancer cells. Urol Sci  2019; 30: 58-66.

[61]
Lee J, Lee J, Kim SJ, Kim JH. Quercetin-3-O-glucoside suppresses pancreatic cancer cell migration induced by tumor-deteriorated growth factors in vitro. Oncol Rep  2016; 35(4): 2473-9.
 [http://dx.doi.org/10.3892/or.2016.4598] [PMID: 26820381]

[62]
Lee H, Lee S, Shin Y, Cho M, Kang H, Cho H. Anti cancer effect of quercetin in xenograft models with EBV associated human gastric carcinoma. Molecules  2016; 21(10): 1286.
 [http://dx.doi.org/10.3390/molecules21101286] [PMID: 27681719]

[63]
Shen X, Si Y, Wang Z, Wang J, Guo Y, Zhang X. Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling. Int J Mol Med  2016; 38(2): 619-26.
 [http://dx.doi.org/10.3892/ijmm.2016.2625] [PMID: 27278820]

[64]
Li H, Chen C. Quercetin has antimetastatic effects on gastric cancer cells via the interruption of uPA/uPAR function by modulating NF-κb, PKC-δ, ERK1/2, and AMPKα. Integr Cancer Ther  2018; 17(2): 511-23.
 [http://dx.doi.org/10.1177/1534735417696702] [PMID: 28627240]

[65]
Zhang JY, Lin MT, Zhou MJ, et al. Combinational treatment of curcumin and quercetin against gastric cancer MGC-803 cells in vitro. Molecules  2015; 20(6): 11524-34.
 [http://dx.doi.org/10.3390/molecules200611524] [PMID: 26111180]

[66]
Catanzaro D, Ragazzi E, Vianello C, Caparrotta L, Montopoli M. Effect of quercetin on cell cycle and cyclin expression in ovarian carcinoma and osteosarcoma cell lines. Nat Prod Commun 2015; 10(8): 1934578X1501000..
 [http://dx.doi.org/10.1177/1934578X1501000813] [PMID: 26434118]

[67]
Lan H, Hong W, Fan P, Qian D, Zhu J, Bai B. Quercetin inhibits cell migration and invasion in human osteosarcoma cells. Cell Physiol Biochem  2017; 43(2): 553-67.
 [http://dx.doi.org/10.1159/000480528] [PMID: 28965117]

[68]
Li S, Pei Y, Wang W, Liu F, Zheng K, Zhang X. Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1. Biomed Pharmacother  2019; 114: 108839.
 [http://dx.doi.org/10.1016/j.biopha.2019.108839] [PMID: 30978523]

[69]
Li Z, Zhang J, Ren X, Liu Q, Yang X. The mechanism of quercetin in regulating osteoclast activation and the PAR2/TRPV1 signaling pathway in the treatment of bone cancer pain. Int J Clin Exp Pathol  2018; 11(11): 5149-56.
 [PMID: 31949595]

[70]
Zhang X, Guo Q, Chen J, Chen Z. Quercetin enhances cisplatin sensitivity of human osteosarcoma cells by modulating microRNA217 KRAS axis. Mol Cells  2015; 38(7): 638-42.
 [http://dx.doi.org/10.14348/molcells.2015.0037] [PMID: 26062553]

[71]
Chen Q, Li P, Li P, Xu Y, Li Y, Tang B. Isoquercitrin inhibits the progression of pancreatic cancer in vivo and in vitro by regulating opioid receptors and the mitogen-activated protein kinase signalling pathway. Oncol Rep  2015; 33(2): 840-8.
 [http://dx.doi.org/10.3892/or.2014.3626] [PMID: 25434366]

[72]
Victor M, Karla CA, Carlos FG Jr, et al. Multitarget effects of quercetin in leukemia cancer. Prev Res  2014; 7(12): 1240-50.

[73]
Mutlu Altunda ˘g E, Yılmaz AM, Serdar BS, Jannuzzi AT, Koçtürk S, Yalçın AS. Synergistic induction of apoptosis by quercetin and curcumin in chronic myeloid leukemia (K562) cells: II. Signal transduction pathways involved. Nutr Cancer  2020; 73(4): 1-10.
 [PMID: 32420759]

[74]
Tian Y, Li Q, Liang Y, Hu G. Enhanced therapeutic efficacy and amelioration of cisplatin-induced nephrotoxicity by quercetin in 1,2-dimethyl hydrazine-induced colon cancer in rats. Indian J Pharmacol  2016; 48(2): 168-71.
 [http://dx.doi.org/10.4103/0253-7613.178834] [PMID: 27127319]

[75]
Li J, Tang C, Li L, Li R, Fan Y. Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo. J Exp Clin Cancer Res  2016; 35(1): 61.
 [http://dx.doi.org/10.1186/s13046-016-0331-1] [PMID: 27039073]

[76]
Santos BL, Oliveira MN, Coelho PLC, et al. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. Chem Biol Interact  2015; 242: 123-38.
 [http://dx.doi.org/10.1016/j.cbi.2015.07.014] [PMID: 26408079]

[77]
Wang G, Wang JJ, Chen XL, et al. The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposomeinduced C6 glioma cell death. Cell Death Dis  2013; 4(8): e746.
 [http://dx.doi.org/10.1038/cddis.2013.242] [PMID: 23907460]

[78]
Jang E, Kim IY, Kim H, et al. Quercetin and chloroquine synergistically kill glioma cells by inducing organelle stress and disrupting Ca2+ homeostasis. Biochem Pharmacol  2020; 178: 114098.
 [http://dx.doi.org/10.1016/j.bcp.2020.114098] [PMID: 32540484]

[79]
Antonis D. Tsiailanis, Alexander Renziehausen, Sofia Kiriakidi, Eirinaios I. Vrettos, Georgios S. Markopoulos, Nisar Sayyad, Baydaa Hirmiz, Marie-Isabel Aguilar, Mark P. Del Borgo, Evangelos Kolettas, Robert E. Widdop, Thomas Mavromoustakos, Tim Crook, Nelofer Syed, Andreas G. Tzakos, Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid. Free Radic Biol Med  2020; 160(20): 391-402.

[80]
Chan CY, Lien CH, Lee MF, Huang CY. Quercetin suppresses cellular migration and invasion in Human Head And Neck Squamous Cell Carcinoma (HNSCC). Biomedicine  2016; 6(3): 15.
 [http://dx.doi.org/10.7603/s40681-016-0015-3] [PMID: 27510965]

[81]
Yuan Z, Wang H, Hu Z, et al. Quercetin inhibits proliferation and drug resistance in KB/VCR oral cancer cells and enhances its sensitivity to vincristine. Nutr Cancer  2015; 67(1): 126-36.
 [http://dx.doi.org/10.1080/01635581.2015.965334] [PMID: 25514492]

[82]
Li H, Piao W, Lau PY, et al. Abstract 98: Stromal-targeting with quercetin in patient-derived models of head and neck squamous cell carcinoma (HNSCC). Cancer Res  2019; 79(S13): 98.
 [http://dx.doi.org/10.1158/1538-7445.AM2019-98]

[83]
Bishayee K, Ghosh S, Mukherjee A, Sadhukhan R, Mondal J, Khuda-Bukhsh AR. Quercetin induces cytochrome c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug‐DNA interaction. Cell Prolif  2013; 46(2): 153-63.
 [http://dx.doi.org/10.1111/cpr.12017] [PMID: 23510470]

[84]
Xiang T, Fang Y, Wang S. Quercetin suppresses HeLa cells by blocking PI3K/Akt pathway. J Huazhong Univ Sci Technolog Med Sci  2014; 34(5): 740-4.
 [http://dx.doi.org/10.1007/s11596-014-1345-6] [PMID: 25318886]

[85]
Lin TH, Hsu WH, Tsai PH, et al. Dietary flavonoids, luteolin and quercetin, inhibit invasion of  cervical cancer by reduction of UBE2S through  epithelial–mesenchymal transition signaling. Food Funct  2017; 8(4): 1558-68.
 [http://dx.doi.org/10.1039/C6FO00551A] [PMID: 28277581]

[86]
Clemente-Soto AF, Salas-Vidal E, Milan-Pacheco C, Sánchez-Carranza JN, Peralta-Zaragoza O, González-Maya L. Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression-independent manner in  HPV-positive human cervical cancer-derived cells. Mol Med Rep  2019; 19(3): 2097-106.
 [http://dx.doi.org/10.3892/mmr.2019.9850] [PMID: 30664221]

[87]
Sundaram M, Raina R, Afroze N, et al. Quercetin modulates signaling pathways and induces apoptosis in cervical cancer cells. Biosci Rep  2019; 39(8): BSR20190720.
 [http://dx.doi.org/10.1042/BSR20190720] [PMID: 31366565]

[88]
Wen-Hsien Hsu Jhih-Yun Ho, Cheng-Wei Lin, Cheng-Ying Chu, Chithan C. Flavonoids luteolin and quercetin inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction. Yao Wu Shi Pin Fen Xi  2018; 26(3): 1180-91.

[89]
Caddeo C, Nacher A, Vassallo A, et al. Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory/oxidative response associated with skin cancer. Int J Pharm  2016; 513(1-2): 153-63.
 [http://dx.doi.org/10.1016/j.ijpharm.2016.09.014] [PMID: 27609664]

[90]
Ali H, Dixit S. Quercetin attenuates the development of 7, 12-dimethyl benz (a) anthracene (DMBA) and croton oil-induced skin cancer in mice. J Biomed Res  2015; 29(2): 139-44.
 [PMID: 25859269]

[91]
Rafiq RA, Quadri A, Nazir LA, Peerzada K, Ganai BA, Tasduq SA. A potent inhibitor of phosphoinositide 3 kinase (PI3K) and mitogen activated protein (MAP) kinase signalling. Quercetin (3,3′,4′,5,7‐pentahydroxyflavone) promotes cell death in ultraviolet (UV)‐B‐irradiated B16F10 melanoma cells. PLoS One  2015; 10(7): e0131253.

[92]
Soll F, Ternent C, Berry IM, Kumari D, Moore TC. Quercetin inhibits proliferation and induces apoptosis of B16 melanoma cells in vitro. assay drug dev technol 2020; 18(6): 261-8.
 [http://dx.doi.org/10.1089/adt.2020.993] [PMID: 32799543]

[93]
Hashemzaei M, Far AD, Yari A, et al. Anticancer and apoptosisinducing effects of quercetin in vitro and in vivo. Oncol Rep  2017; 38(2): 819-28.
 [http://dx.doi.org/10.3892/or.2017.5766] [PMID: 28677813]

[94]
Chen R, Hollborn M, Grosche A, et al. Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells. Mol Vis  2014; 20: 242-58.
 [PMID: 24623967]

[95]
Ho TY, Lo HY, Liu IC, et al. The protective effect of quercetin on retinal inflammation in mice: the involvement of tumor necrosis factor/nuclear factor-κB signaling pathways. Food Funct  2020; 11(9): 8150-60.
 [http://dx.doi.org/10.1039/D0FO01324B] [PMID: 32966478]

[96]
Mutlu Altundağ E, Kasacı T, Yılmaz AM, et al. Quercetin induced cell death in human papillary thyroid cancer (B‐CPAP) cells. J Thyroid Res  2016; 2016: 1-10.
 [http://dx.doi.org/10.1155/2016/9843675] [PMID: 27057371]

[97]
Giuliani C, Noguchi Y, Harii N, et al. The flavonoid quercetin regulates growth and gene expression in rat FRTL-5 thyroid cells. Endocrinology  2008; 149(1): 84-92.
 [http://dx.doi.org/10.1210/en.2007-0618] [PMID: 17962351]

[98]
Giuliani C, Bucci I, Di Santo S, et al. The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function. Food Chem Toxicol  2014; 66: 23-9.
 [http://dx.doi.org/10.1016/j.fct.2014.01.016] [PMID: 24447974]

[99]
Mutlu AE, Mine Yilmaz A, Kasaci T, Corek C, Taga Y, Suha YA. The role of HSP90 in quercetin-induced apoptosis in human papillary thyroid (B-CPAP) cancer cells. Free Radical Biol Med  2014; 75(S1): S43.
 [http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.797]

[100]
Li W, Liu M, Xu YF, et al. Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a. Oncol Rep  2014; 31(1): 117-24.
 [http://dx.doi.org/10.3892/or.2013.2811] [PMID: 24173369]

[101]
Li N, Sun C, Zhou B, et al. Low concentration of quercetin antagonizes the cytotoxic effects of anti-neoplastic drugs in ovarian cancer. PLoS One  2014; 9(7): e100314.
 [http://dx.doi.org/10.1371/journal.pone.0100314] [PMID: 24999622]

[102]
Li X, Wang X, Zhang M, Li A, Sun Z, Yu Q. Quercetin potentiates the antitumor activity of rituximab in diffuse large B-cell lymphoma by inhibiting STAT3 pathway. Cell Biochem Biophys  2014; 70(2): 1357-62.
 [http://dx.doi.org/10.1007/s12013-014-0064-8] [PMID: 24902540]

[103]
Li W, Zhao Y, Tao B, Zhang Y. Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells. Chin J Integr Med  2014; 20(10): 776-81.
 [http://dx.doi.org/10.1007/s11655-014-1817-3] [PMID: 24928376]

[104]
Gao X, Wang B, Wei X, et al. Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Nanoscale  2012; 4(22): 7021-30.
 [http://dx.doi.org/10.1039/c2nr32181e] [PMID: 23044718]

[105]
Ren MX, Deng XH, Ai F, Yuan GY, Song HY. Effect of quercetin on the proliferation of the human ovarian cancer cell line SKOV-3 in vitro. Exp Ther Med  2015; 10(2): 579-83.
 [http://dx.doi.org/10.3892/etm.2015.2536] [PMID: 26622357]

[106]
Xu G, Li B, Wang T, et al. Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system. RSC Advances  2018; 8(38): 21229-42.
 [http://dx.doi.org/10.1039/C8RA03274B] [PMID: 35539921]

[107]
Liu Y, Gong W, Yang ZY, et al. Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer. Apoptosis  2017; 22(4): 544-57.
 [http://dx.doi.org/10.1007/s10495-016-1334-2] [PMID: 28188387]

[108]
Yamauchi K, Afroze SH, Mitsunaga T, et al. 3,4′,7-Otrimethylquercetin inhibits invasion and migration of ovarian Cancer cells. Anticancer Res  2017; 37(6): 2823-9.
 [PMID: 28551617]

[109]
Teekaraman D, Elayapillai SP, Viswanathan MP, Jagadeesan A. Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1 cell line. Chem Biol Interact  2019; 300: 91-100.
 [http://dx.doi.org/10.1016/j.cbi.2019.01.008] [PMID: 30639267]

[110]
Gong C, Yang Z, Zhang L, Wang Y, Gong W, Liu Y. Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway. OncoTargets Ther  2017; 11: 17-27.
 [http://dx.doi.org/10.2147/OTT.S147316] [PMID: 29317830]

[111]
Yang Z, Liu Y, Liao J, et al. Retracted: Quercetin induces endoplasmic reticulum stress to enhance c DDP cytotoxicity in ovarian cancer: involvement of STAT 3 signaling. FEBS J  2015; 282(6): 1111-25.
 [http://dx.doi.org/10.1111/febs.13206] [PMID: 25611565]

[112]
Long Q, Xie Y, Huang Y, et al. Induction of apoptosis and inhibition of angiogenesis by PEGylated liposomal quercetin in both cisplatin-sensitive and cisplatin-resistant ovarian cancers. J Biomed Nanotechnol  2013; 9(6): 965-75.
 [http://dx.doi.org/10.1166/jbn.2013.1596] [PMID: 23858960]

[113]
Yi L, Zongyuan Y, Cheng G, Lingyun Z. GuiLian Y, Wei G. Quercetin enhances apoptotic effect of tumor necrosis factor related apoptosis inducing ligand (TRAIL) in ovarian cancer cells through Reactive Oxygen Species (ROS) mediated CCAAT enhancer‐binding protein homologous protein (CHOP) death receptor 5 pathway. Cancer Sci  2014; 105(5): 520-7.
 [http://dx.doi.org/10.1111/cas.12395] [PMID: 24612139]

[114]
Scambia G, Panici PB, Ranelletti FO, et al. Quercetin enhances transforming growth factor β1, secretion by human ovarian cancer cells. Int J Cancer  1994; 57(2): 211-5.
 [http://dx.doi.org/10.1002/ijc.2910570214] [PMID: 8157359]

[115]
Shen F, Herenyiova M, Weber G. Synergistic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin in human ovarian carcinoma cells. Life Sci  1999; 64(21): 1869-76.
 [http://dx.doi.org/10.1016/S0024-3205(99)00133-2] [PMID: 10353585]

[116]
Heeba GH, Mahmoud ME. Dual effects of quercetin in doxorubicin-induced nephrotoxicity in rats and its modulation of the cytotoxic activity of doxorubicin on human carcinoma cells. Environ Toxicol  2016; 31(5): 624-36.
 [PMID: 25411067]

[117]
Ren J, Li J, Liu X, et al. Quercetin inhibits fibroblast activation and kidney fibrosis involving the suppression of mammalian target of rapamycin and β-catenin Signaling. Sci Rep  2016; 6(1): 23968.
 [http://dx.doi.org/10.1038/srep23968] [PMID: 27052477]

[118]
Vargas F, Romecín P, García-Guillén AI, et al. Flavonoids in kidney health and disease. Front Physiol  2018; 9: 394.
 [http://dx.doi.org/10.3389/fphys.2018.00394] [PMID: 29740333]

[119]
Demiroglu-Zergeroglu A, Ergene E, Ayvali N, Kuete V, Sivas H. Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells. BMC Complement Altern Med  2016; 16(1): 281.
 [http://dx.doi.org/10.1186/s12906-016-1267-x] [PMID: 27514524]

[120]
Lee YJ, Lee DM, Lee SH. Nrf2 expression and apoptosis in quercetin-treated malignant mesothelioma cells. Mol Cells  2015; 38(5): 416-25.
 [http://dx.doi.org/10.14348/molcells.2015.2268] [PMID: 25896339]

[121]
Ranganathan S, Halagowder D, Sivasithambaram ND. Quercetin suppresses twist to induce apoptosis in MCF-7 breast cancer cells. PLoS One  2015; 10(10): e0141370.
 [http://dx.doi.org/10.1371/journal.pone.0141370] [PMID: 26491966]

[122]
Bulavin DV, Phillips C, Nannenga B, et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK–mediated activation of the p16Ink4a-p19Arf pathway. Nat Genet  2004; 36(4): 343-50.
 [http://dx.doi.org/10.1038/ng1317] [PMID: 14991053]

[123]
Choi EJ, Bae SM, Ahn WS. Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells. Arch Pharm Res  2008; 31(10): 1281-5.
 [http://dx.doi.org/10.1007/s12272-001-2107-0] [PMID: 18958418]

[124]
Huang C, Lee SY, Lin CL, et al. Co-treatment with quercetin and 1,2,3,4,6-penta-O-galloyl-β-D-glucose causes cell cycle arrest and apoptosis in human breast cancer MDA-MB-231 and AU565 cells. J Agric Food Chem  2013; 61(26): 6430-45.
 [http://dx.doi.org/10.1021/jf305253m] [PMID: 23731217]

[125]
Gulati N, Laudet B, Zohrabian VM, Murali R, Jhanwar-Uniyal M. The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. Anticancer Res  2006; 26(2A): 1177-81.
 [PMID: 16619521]

[126]
Jeong JH, An JY, Kwon YT, Li LY, Lee YJ. Quercetin-induced ubiquitination and down-regulation of Her-2/ neu. J Cell Biochem  2008; 105(2): 585-95.
 [http://dx.doi.org/10.1002/jcb.21859] [PMID: 18655187]

[127]
Zhang F, Du G. Dysregulated lipid metabolism in cancer. World J Biol Chem  2012; 3(8): 167-74.
 [http://dx.doi.org/10.4331/wjbc.v3.i8.167] [PMID: 22937213]

[128]
Impheng H, Pongcharoen S, Richert L, Pekthong D, Srisawang P. The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells. PLoS One  2014; 9(9): e107842.
 [http://dx.doi.org/10.1371/journal.pone.0107842] [PMID: 25255125]

[129]
Song HJ, Sneddon AA, Heys SD, Wahle KWJ. Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids. Prostaglandins Leukot Essent Fatty Acids  2012; 87(6): 197-203.
 [http://dx.doi.org/10.1016/j.plefa.2012.09.002] [PMID: 23142364]

[130]
Huang SL, Hsu CL, Yen GC. Growth inhibitory effect of quercetin on SW 872 human liposarcoma cells. Life Sci  2006; 79(2): 203-9.
 [http://dx.doi.org/10.1016/j.lfs.2005.12.046] [PMID: 16455111]

[131]
Oakes S, Lin S, Bassik M. The control of endoplasmic reticuluminitiated apoptosis by the BCL-2 family of proteins. Curr Mol Med  2006; 6(1): 99-109.
 [http://dx.doi.org/10.2174/156652406775574587] [PMID: 16472117]

[132]
van Delft MF, Huang DCS. How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res  2006; 16(2): 203-13.
 [http://dx.doi.org/10.1038/sj.cr.7310028] [PMID: 16474435]

[133]
Dechsupa S, Kothan S, Vergote J, et al. Quercetin, Siamois 1 and siamois 2 induce apoptosis in human breast cancer MDA-MB-435 cells xenograft in vivo. Cancer Biol Ther  2007; 6(1): 56-61.
 [http://dx.doi.org/10.4161/cbt.6.1.3548] [PMID: 17172819]

[134]
Chien SY, Wu YC, Chung JG, et al. Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Hum Exp Toxicol  2009; 28(8): 493-503.
 [http://dx.doi.org/10.1177/0960327109107002] [PMID: 19755441]

[135]
Seo HS, Ju J, Jang K, Shin I. Induction of apoptotic cell death by phytoestrogens by up-regulating the levels of phospho-p53 and p21 in normal and malignant estrogen receptor α–negative breast cells. Nutr Res  2011; 31(2): 139-46.
 [http://dx.doi.org/10.1016/j.nutres.2011.01.011] [PMID: 21419318]

[136]
Tao S, He H, Chen Q. Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells. Mol Cell Biochem  2015; 402(1-2): 93-100.
 [http://dx.doi.org/10.1007/s11010-014-2317-7] [PMID: 25596948]

[137]
Dhumale SS, Waghela BN, Pathak C. Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells. IUBMB Life  2015; 67(5): 361-73.
 [http://dx.doi.org/10.1002/iub.1379] [PMID: 25983116]

[138]
Li S, Qiao S, Zhang J, Li K. Quercetin increase the chemosensitivity of breast cancer cells to doxorubicin via PTEN/Akt pathway. Anticancer Agents Med Chem  2015; 15(9): 1185-9.
 [http://dx.doi.org/10.2174/1871520615999150121121708] [PMID: 25612678]

[139]
Saleem TH, Attya AM, Ahmed EA, Ragab SMM, Abdallah MAA, Omar HM. Possible protective effects of quercetin and sodium gluconate against colon cancer induction by dimethylhydrazine in mice. Asian Pac J Cancer Prev  2015; 16(14): 5823-8.
 [http://dx.doi.org/10.7314/APJCP.2015.16.14.5823] [PMID: 26320457]

[140]
Refolo MG, D’Alessandro R, Malerba N, et al. Anti‐proliferative and pro apoptotic effects of flavonoid quercetin are mediated by CB1 receptor in human colon cancer cell Lines. J Cell Physiol  2015; 230(12): 2973-80.
 [http://dx.doi.org/10.1002/jcp.25026] [PMID: 25893829]

[141]
Xu G, Shi H, Ren L, et al. Enhancing the anti-colon cancer activity of quercetin by self-assembled micelles. Int J Nanomedicine  2015; 10: 2051-63.
 [PMID: 25844036]

[142]
Zhang XA, Zhang S, Yin Q, Zhang J. Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway. Pharmacogn Mag  2015; 11(42): 404-9.
 [http://dx.doi.org/10.4103/0973-1296.153096] [PMID: 25829782]

[143]
Kim GT, Lee SH, Kim YM. Quercetin regulates sestrin 2‐AMPK‐mTOR signaling pathway and induces apoptosis via increased intracellular ROS in HCT116 colon cancer cells. J Cancer Prev  2013; 18(3): 264-70.
 [http://dx.doi.org/10.15430/JCP.2013.18.3.264] [PMID: 25337554]

[144]
Kim H, Moon JY, Ahn KS, Cho SK. Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. Oxid Med Cell Longev  2013; 2013(596496): 1-10.
 [http://dx.doi.org/10.1155/2013/596496] [PMID: 24379902]

[145]
Amado NG, Predes D, Fonseca BF, et al. Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway. J Biol Chem  2014; 289(51): 35456-67.
 [http://dx.doi.org/10.1074/jbc.M114.621599] [PMID: 25359775]

[146]
Kim GT, Lee SH, Kim J, Kim YM. Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner. Int J Mol Med  2014; 33(4): 863-9.
 [http://dx.doi.org/10.3892/ijmm.2014.1658] [PMID: 24535669]

[147]
Atashpour S, Fouladdel S, Movahhed TK, et al. Quercetin induces cell cycle arrest and apoptosis in CD133(+) cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin. Iran J Basic Med Sci  2015; 18(7): 635-43.
 [PMID: 26351552]

[148]
Cho SY, Kim MK, Park K, Choo H, Chong Y. Quercetin–POC conjugates: Differential stability and bioactivity profiles between breast cancer (MCF-7) and colorectal carcinoma (HCT116) cell lines. Bioorg Med Chem  2013; 21(7): 1671-9.
 [http://dx.doi.org/10.1016/j.bmc.2013.01.057] [PMID: 23434132]

[149]
Appari M, Babu KR, Kaczorowski A, Gros W, Her I. Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition. Int J Oncol  2014; 45(4): 1391-400.
 [http://dx.doi.org/10.3892/ijo.2014.2539] [PMID: 25017900]

[150]
Lee JH, Lee HB, Jung GO, Oh JT, Park DE, Chae KM. Effect of quercetin on apoptosis of PANC-1 cells. J Korean Surg Soc  2013; 85(6): 249-60.
 [http://dx.doi.org/10.4174/jkss.2013.85.6.249] [PMID: 24368982]

[151]
Angst E, Park JL, Moro A, et al. The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo. Pancreas  2013; 42(2): 223-9.
 [http://dx.doi.org/10.1097/MPA.0b013e318264ccae] [PMID: 23000892]

[152]
Harris DM, Li L, Chen M, Lagunero FT, Go VLW, Boros LG. Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75. Metabolomics  2012; 8(2): 201-10.
 [http://dx.doi.org/10.1007/s11306-011-0300-9] [PMID: 22754424]

[153]
Naghavi M, Wang H, Lozano R, et al. Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet  2015; 385(9963): 117-71.
 [http://dx.doi.org/10.1016/S0140-6736(14)61682-2] [PMID: 25530442]

[154]
Mandal AK, Ghosh D, Sarkar S, Ghosh A, Swarnakar S, Das N. Nanocapsulated quercetin downregulates rat hepatic MMP-13 and controls diethylnitrosamine-induced carcinoma. Nanomedicine  2014; 9(15): 2323-37.
 [http://dx.doi.org/10.2217/nnm.14.11] [PMID: 24593002]

[155]
Sudan S, Rupasinghe HPV. Antiproliferative activity of long chain acylated esters of quercetin-3- O -glucoside in hepatocellular carcinoma HepG2 cells. Exp Biol Med  2015; 240(11): 1452-64.
 [http://dx.doi.org/10.1177/1535370215570828] [PMID: 25681471]

[156]
Oršolić N, Car N. Quercetin and hyperthermia modulate cisplatin-induced DNA damage in tumor and normal tissues in vivo. Tumour Biol  2014; 35(7): 6445-54.
 [http://dx.doi.org/10.1007/s13277-014-1843-y] [PMID: 24682902]

[157]
Zhao P, Mao JM, Zhang SY, Zhou ZQ, Tan Y, Zhang Y. Quercetin induces HepG2 cell apoptosis by inhibiting fatty acid biosynthesis. Oncol Lett  2014; 8(2): 765-9.
 [http://dx.doi.org/10.3892/ol.2014.2159] [PMID: 25009654]

[158]
Waizenegger J, Lenze D, Luckert C, Seidel A, Lampen A, Hessel S. Dose-dependent induction of signaling pathways by the flavonoid quercetin in human primary hepatocytes: A transcriptomic study. Mol Nutr Food Res  2015; 59(6): 1117-29. [a]
 [http://dx.doi.org/10.1002/mnfr.201400764] [PMID: 25788151]

[159]
Chen W, Wang X, Zhuang J, Zhang L, Lin Y. Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells. Carcinogenesis  2007; 28(10): 2114-21.
 [http://dx.doi.org/10.1093/carcin/bgm133] [PMID: 17548900]

[160]
Kuhar M, Sen S, Singh N. Role of mitochondria in quercetin-enhanced chemotherapeutic response in human non-small cell lung carcinoma H-520 cells. Anticancer Res  2006; 26(2A): 1297-303.
 [PMID: 16619537]

[161]
Chen W, Padilla MT, Xu X, et al. Quercetin inhibits multiple pathways involved in interleukin 6 secretion from human lung fibroblasts and activity in bronchial epithelial cell transformation induced by benzo[a]pyrene diol epoxide. Mol Carcinog  2016; 55(11): 1858-66.
 [http://dx.doi.org/10.1002/mc.22434] [PMID: 26609631]

[162]
Zhao X, Zhang J. Mechanisms for quercetin in prevention of lung cancer cell growth and metastasis. Zhong Nan Da Xue Xue Bao Yi Xue Ban  2015; 40(6): 592-7.
 [PMID: 26164506]

[163]
Sonoki H, Sato T, Endo S, et al. Quercetin decreases claudin 2 expression mediated by up‐regulation of microRNA miR‐16 in lung adenocarcinoma A549 cells. Nutrients  2015; 7(6): 4578-92.
 [http://dx.doi.org/10.3390/nu7064578] [PMID: 26061016]

[164]
Lee SH, Lee EJ, Min KH, et al. Quercetin enhances chemosensitivity to gemcitabine in lung cancer cells by inhibiting heat shock protein 70 expression. Clin Lung Cancer  2015; 16(6): e235-43.
 [http://dx.doi.org/10.1016/j.cllc.2015.05.006] [PMID: 26050647]

[165]
Liu Y, Wu YM, Zhang PY. Protective effects of curcumin and quercetin during benzo(a)pyrene induced lung carcinogenesis in mice. Eur Rev Med Pharmacol Sci  2015; 19(9): 1736-43.
 [PMID: 26004618]

[166]
Moon JH, Eo SK, Lee JH, Park SY. Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep  2015; 34(1): 375-81.
 [http://dx.doi.org/10.3892/or.2015.3991] [PMID: 25997470]

[167]
Wang J, Zhang YY, Cheng J, Zhang JL, Li BS. Preventive and therapeutic effects of quercetin on experimental radiation induced lung injury in mice. Asian Pac J Cancer Prev  2015; 16(7): 2909-14.
 [http://dx.doi.org/10.7314/APJCP.2015.16.7.2909] [PMID: 25854382]

[168]
Mukherjee A, Khuda-Bukhsh AR. Quercetin down regulates IL6/STAT 3 signals to induce mitochondrial mediated apoptosis in a nonsmall cell lung cancer cell line A549. J Pharmacopuncture  2015; 18(1): 19-26.
 [http://dx.doi.org/10.3831/KPI.2015.18.002] [PMID: 25830055]

[169]
Zhao X, Wang Q, Yang S, et al. Quercetin inhibits angiogenesis by targeting calcineurin in the xenograft model of human breast cancer. Eur J Pharmacol  2016; 781: 60-8.
 [http://dx.doi.org/10.1016/j.ejphar.2016.03.063] [PMID: 27041643]

[170]
Song LM, Wang GD, Wang HP, Xing NZ. Effect of 2-methoxyestradiol combined with quercetin on prostate cancer in vitro. Zhonghua Yi Xue Za Zhi  2016; 96(2): 95-9.
 [PMID: 26792689]

[171]
Hamidullah K, Kumar R, Saini KS, et al. Quercetin-6-C-β-dglucopyranoside, natural analog of quercetin exhibits anti-prostate cancer activity by inhibiting Akt-mTOR pathway via aryl hydrocarbon receptor. Biochimie  2015; 119: 68-79.
 [http://dx.doi.org/10.1016/j.biochi.2015.10.012] [PMID: 26476001]

[172]
Paller CJ, Kanaan YM, Beyene DA, et al. Risk of prostate cancer in African-American men: Evidence of mixed effects of dietary quercetin by serum vitamin D status. Prostate  2015; 75(13): 1376-83.
 [http://dx.doi.org/10.1002/pros.23018] [PMID: 26047130]

[173]
Yang FQ, Liu M, Li W, Che JP, Wang GC, Zheng JH. Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA-21. Mol Med Rep  2015; 11(2): 1085-92.
 [http://dx.doi.org/10.3892/mmr.2014.2813] [PMID: 25354548]

[174]
Yang F, Song L, Wang H, Wang J, Xu Z, Xing N. Combination of quercetin and 2 methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC 3 cells xenograft tumor growth. PLoS One  2015; 10(5): e0128277.
 [http://dx.doi.org/10.1371/journal.pone.0128277] [PMID: 26011145]

[175]
Wang Y, Han A, Chen E, et al. The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells. Int J Oncol  2015; 46(5): 1924-34.
 [http://dx.doi.org/10.3892/ijo.2015.2931] [PMID: 25776829]

[176]
Wang P, Henning SM, Heber D, Vadgama JV. Sensitization to docetaxel in prostate cancer cells by green tea and quercetin. J Nutr Biochem  2015; 26(4): 408-15.
 [http://dx.doi.org/10.1016/j.jnutbio.2014.11.017] [PMID: 25655047]

[177]
Wang P, Phan T, Gordon D, Chung S, Henning SM, Vadgama JV. Arctigenin in combination with quercetin synergistically enhances the antiproliferative effect in prostate cancer cells. Mol Nutr Food Res  2015; 59(2): 250-61.
 [http://dx.doi.org/10.1002/mnfr.201400558] [PMID: 25380086]

[178]
Di Lorenzo G, Pagliuca M, Perillo T, et al. Complete response and fatigue improvement with the combined use of cyclophosphamide and quercetin in a patient with metastatic bladder cancer.  A case report Medicine  2016; 95(5): e2598.
 [http://dx.doi.org/10.1097/MD.0000000000002598] [PMID: 26844468]

[179]
Wei L, Liu JJ, Cao J, Du NC, Ji LN, Yang XL. Role of autophagy in quercetin-induced apoptosis in human bladder carcinoma BIU-87 cells. Zhonghua Zhong Liu Za Zhi  2012; 34(6): 414-8.
 [PMID: 22967441]

[180]
Kim MC, Lee HJ, Lim B, et al. Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells. Int J Mol Med  2014; 33(6): 1657-63.
 [http://dx.doi.org/10.3892/ijmm.2014.1704] [PMID: 24647664]

[181]
Borska S, Chmielewska M, Wysocka T, Drag-Zalesinska M, Zabel M, Dziegiel P. In vitro effect of quercetin on human gastric carcinoma: Targeting cancer cells death and MDR. Food Chem Toxicol  2012; 50(9): 3375-83.
 [http://dx.doi.org/10.1016/j.fct.2012.06.035] [PMID: 22750388]

[182]
Qin Y, He LY, Chen Y, Wang WY, Zhao XH, Wu MY. Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway. Xibao Yu Fenzi Mianyixue Zazhi  2012; 28(1): 12-6.
 [PMID: 22230496]

[183]
Wang K, Liu R, Li J, et al. Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxiainduced factor 1α-mediated signaling. Autophagy  2011; 7(9): 966-78.
 [http://dx.doi.org/10.4161/auto.7.9.15863] [PMID: 21610320]

[184]
Yu ZJ, He LY, Chen Y, Wu MY, Zhao XH, Wang ZY. Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells. Xibao Yu Fenzi Mianyixue Zazhi  2009; 25(8): 678-80.
 [PMID: 19664387]

[185]
Berndt K, Campanile C, Muff R, Strehler E, Born W, Fuchs B. Evaluation of quercetin as a potential drug in osteosarcoma treatment. Anticancer Res  2013; 33(4): 1297-306.
 [PMID: 23564766]

[186]
Yin J, Xie X, Jia Q, et al. Effect and mechanism of quercetin on proliferation and apoptosis of human osteosarcoma cell U-2OS/MTX300. Zhongguo Zhongyao Zazhi  2012; 37(5): 611-4.
 [PMID: 22693904]

[187]
Şekeroğlu ZA, Şekeroğlu V. Effects of Viscum album L. extract and quercetin on methotrexate-induced cyto-genotoxicity in mouse bone-marrow cells. Mutat Res Genet Toxicol Environ Mutagen  2012; 746(1): 56-9.
 [http://dx.doi.org/10.1016/j.mrgentox.2012.02.012] [PMID: 22464986]

[188]
Attia SM. The impact of quercetin on cisplatin-induced clastogenesis and apoptosis in murine marrow cells. Mutagenesis  2010; 25(3): 281-8.
 [http://dx.doi.org/10.1093/mutage/geq004] [PMID: 20156843]

[189]
Liang W, Li X, Li C, et al. Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. Mol Med Rep  2011; 4(5): 1017-23.
 [PMID: 21805050]

[190]
Xie X, Yin J, Jia Q, et al. Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. Oncol Rep  2011; 26(3): 687-93.
 [PMID: 21617882]

[191]
Han YQ, Hong Y, Su XL, Wang JR. Quercetin enhances the antileukemic effect of adriamycin. Zhongguo Shi Yan Xue Ye Xue Za Zhi  2014; 22(6): 1555-60.
 [PMID: 25543474]

[192]
Han Y, Yu H, Wang J, Ren Y, Su X, Shi Y. Quercetin alleviates myocyte toxic and sensitizes anti-leukemic effect of adriamycin. Hematology  2015; 20(5): 276-83.
 [http://dx.doi.org/10.1179/1607845414Y.0000000198] [PMID: 25201038]

[193]
Brisdelli F, Bennato F, Bozzi A, Cinque B, Mancini F, Iorio R. ELF-MF attenuates quercetin-induced apoptosis in K562 cells through modulating the expression of Bcl-2 family proteins. Mol Cell Biochem  2014; 397(1-2): 33-43.
 [http://dx.doi.org/10.1007/s11010-014-2169-1] [PMID: 25084985]

[194]
Baran I, Ionescu D, Filippi A, et al. Novel insights into the antiproliferative effects and synergism of quercetin and menadione in human leukemia Jurkat T cells. Leuk Res  2014; 38(7): 836-49.
 [http://dx.doi.org/10.1016/j.leukres.2014.04.010] [PMID: 24862793]

[195]
Granato M, Rizzello C, Romeo MA, et al. Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt’s lymphoma. Int J Biochem Cell Biol  2016; 79: 393-400.
 [http://dx.doi.org/10.1016/j.biocel.2016.09.006] [PMID: 27620077]

[196]
Ma Y, Jin Z, Huang J, et al. Quercetin suppresses the proliferation of multiple myeloma cells by down-regulating IQ motif-containing GTPase activating protein 1 expression and extracellular signal-regulated kinase activation. Leuk Lymphoma  2014; 55(11): 2597-604.
 [http://dx.doi.org/10.3109/10428194.2013.879128] [PMID: 24397597]

[197]
Chang JL, Chow JM, Chang JH, et al. Quercetin simultaneously induces G 0 /G 1 -phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells. Environ Toxicol  2017; 32(7): 1857-68.
 [http://dx.doi.org/10.1002/tox.22408] [PMID: 28251795]

[198]
Chae J, Cho JH, Lee KA, et al. Role of transcription factor Sp1 in the quercetin-mediated inhibitory effect on human malignant pleural mesothelioma. Int J Mol Med  2012; 30(4): 835-41.
 [http://dx.doi.org/10.3892/ijmm.2012.1075] [PMID: 22842769]

[199]
Park MH, Min DS. Quercetin-induced downregulation of phospholipase D1 inhibits proliferation and invasion in U87 glioma cells. Biochem Biophys Res Commun  2011; 412(4): 710-5.
 [http://dx.doi.org/10.1016/j.bbrc.2011.08.037] [PMID: 21867678]

[200]
Wang H, Yuan Z, Chen Z, Yao F, Hu Z, Wu B. Effect of quercetin on glioma cell U87 apoptosis and feedback regulation of MDM2-p53. Nan Fang Yi Ke Da Xue Xue Bao  2014; 34(5): 686-9.
 [PMID: 24849437]

[201]
Jakubowicz-Gil J, Langner E, Bądziul D, Wertel I, Rzeski W. Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment. Toxicol Appl Pharmacol  2013; 273(3): 580-9.
 [http://dx.doi.org/10.1016/j.taap.2013.10.003] [PMID: 24126416]

[202]
Jakubowicz-Gil J, Langner E, Bądziul D, Wertel I, Rzeski W. Quercetin and sorafenib as a novel and effective couple in programmed cell death induction in human gliomas. Neurotox Res  2014; 26(1): 64-77.
 [http://dx.doi.org/10.1007/s12640-013-9452-x] [PMID: 24366851]

[203]
Pozsgai E, Bellyei S, Cseh A, et al. Quercetin increases the efficacy of glioblastoma treatment compared to standard chemoradiotherapy by the suppression of PI-3-kinase-Akt pathway. Nutr Cancer  2013; 65(7): 1059-66.
 [http://dx.doi.org/10.1080/01635581.2013.810291] [PMID: 24032376]

[204]
Pan HC, Jiang Q, Yu Y, Mei JP, Cui YK, Zhao WJ. Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells. Neurochem Int  2015; 80: 60-71.
 [http://dx.doi.org/10.1016/j.neuint.2014.12.001] [PMID: 25481090]

[205]
Sang D, Li R, Lan Q. Quercetin sensitizes human glioblastoma cells to temozolomide in vitro via inhibition of Hsp27. Acta Pharmacol Sin  2014; 35(6): 832-8.
 [http://dx.doi.org/10.1038/aps.2014.22] [PMID: 24902789]

[206]
Carbone M, Amelio I, Affar EB, et al. Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death Differ  2018; 25(11): 1885-904.
 [http://dx.doi.org/10.1038/s41418-018-0213-5] [PMID: 30323273]

[207]
Lai WW, Hsu SC, Chueh FS, et al. Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res  2013; 33(5): 1941-50.
 [PMID: 23645742]

[208]
Huang CY, Chan CY, Chou IT, Lien CH, Hung HC, Lee MF. Quercetin induces growth arrest through activation of FOXO1 transcription factor in EGFR-overexpressing oral cancer cells. J Nutr Biochem  2013; 24(9): 1596-603.
 [http://dx.doi.org/10.1016/j.jnutbio.2013.01.010] [PMID: 23618529]

[209]
Chen SF, Nieh S, Jao SW, et al. Quercetin suppresses drugresistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells. PLoS One  2012; 7(11): e49275.
 [http://dx.doi.org/10.1371/journal.pone.0049275] [PMID: 23152886]

[210]
Chen SF, Nien S, Wu CH, Liu CL, Chang YC, Lin YS. Reappraisal of the anticancer efficacy of quercetin in oral cancer cells. J Chin Med Assoc  2013; 76(3): 146-52.
 [http://dx.doi.org/10.1016/j.jcma.2012.11.008] [PMID: 23497967]

[211]
Chang WW, Hu FW, Yu CC, et al. Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck  2013; 35(3): 413-9.
 [http://dx.doi.org/10.1002/hed.22982] [PMID: 22422628]

[212]
Priyadarsini RV, Nagini S. Quercetin suppresses cytochrome P450 mediated ROS generation and NFκB activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas. Free Radic Res  2012; 46(1): 41-9.
 [http://dx.doi.org/10.3109/10715762.2011.637204] [PMID: 22044346]

[213]
Priyadarsini RV, Vinothini G, Murugan RS, Manikandan P, Nagini S. The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors. Nutr Cancer  2011; 63(2): 218-26.
 [http://dx.doi.org/10.1080/01635581.2011.523503] [PMID: 21294050]

[214]
Kang JW, Kim JH, Song K, Kim SH, Yoon JH, Kim KS. Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. Phytother Res  2010; 24(S1): S77-82.
 [http://dx.doi.org/10.1002/ptr.2913] [PMID: 19585476]

[215]
Ojesina AI, Lichtenstein L, Freeman SS, et al. Landscape of genomic alterations in cervical carcinomas. Nature  2014; 506(7488): 371-5.
 [http://dx.doi.org/10.1038/nature12881] [PMID: 24390348]

[216]
Liu SY, Zheng PS. High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer. Oncotarget  2013; 4(12): 2462-75.
 [http://dx.doi.org/10.18632/oncotarget.1578] [PMID: 24318570]

[217]
Zhang WT, Zhang W, Zhong YJ, Lü QY, Cheng J. Impact of quercetin on the expression of heparanase in cervical cancer cells. Zhonghua Fu Chan Ke Za Zhi  2013; 48(3): 198-203.
 [PMID: 23849943]

[218]
Bądziul D, Jakubowicz-Gil J, Paduch R, Głowniak K, Gawron A. Combined treatment with quercetin and imperatorin as a potent strategy for killing HeLa and Hep-2 cells. Mol Cell Biochem  2014; 392(1-2): 213-27.
 [http://dx.doi.org/10.1007/s11010-014-2032-4] [PMID: 24682729]

[219]
Luo C, Liu Y, Wang P, et al. The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression. Biomed Pharmacother  2016; 82: 595-605.
 [http://dx.doi.org/10.1016/j.biopha.2016.05.029] [PMID: 27470402]

[220]
Vidya Priyadarsini R, Senthil Murugan R, Maitreyi S, Ramalingam K, Karunagaran D, Nagini S. The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur J Pharmacol  2010; 649(1-3): 84-91.
 [http://dx.doi.org/10.1016/j.ejphar.2010.09.020] [PMID: 20858478]

[221]
Huang LQ, Zhang W, Yang Y, Tao L. Effects and its mechanism of quercetin on cervical cancer HeLa cells. Zhonghua Fu Chan Ke Za Zhi  2009; 44(6): 436-9.
 [PMID: 19953944]

[222]
Jung M, Bu SY, Tak KH, Park JE, Kim E. Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer. Nutr Res Pract  2013; 7(6): 439-45.
 [http://dx.doi.org/10.4162/nrp.2013.7.6.439] [PMID: 24353828]

[223]
Robbins RJ, Schlumberger MJ. The evolving role of (131)I for the treatment of differentiated thyroid carcinoma. J Nucl Med  2005; 46 (Suppl. 1): 28S-37S.
 [PMID: 15653649]

[224]
Chow SM. Side effects of high‐dose radioactive iodine for ablation or treatment of differentiated thyroid carcinoma. Hong Kong Journal of Radiology  2005; 8: 127-35.

[225]
Shafabakhsh R, Asemi Z. Quercetin: a natural compound for ovarian cancer treatment. J Ovarian Res  2019; 12(1): 55.
 [http://dx.doi.org/10.1186/s13048-019-0530-4] [PMID: 31202269]

[226]
Nessa MU, Beale P, Chan C, Yu JQ, Huq F. Synergism from combinations of cisplatin and oxaliplatin with quercetin and thymoquinone in human ovarian tumour models. Anticancer Res  2011; 31(11): 3789-97.
 [PMID: 22110201]

[227]
Maciejczyk A, Surowiak P. Quercetin inhibits proliferation and increases sensitivity of ovarian cancer cells to cisplatin and paclitaxel. Ginekol Pol  2013; 84(7): 590-5.
 [http://dx.doi.org/10.17772/gp/1609] [PMID: 24032269]

[228]
Lipworth L, Tarone RE, McLaughlin JK. The epidemiology of renal cell carcinoma. J Urol  2006; 176(6): 2353-8.
 [http://dx.doi.org/10.1016/j.juro.2006.07.130] [PMID: 17085101]

[229]
Sanchez-Gonzalez PD, Lopez-Hernandez FJ, Perez-Barriocanal F, Morales AI, Lopez-Novoa JM. Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity. Nephrol Dial Transplant  2011; 26(11): 3484-95.
 [http://dx.doi.org/10.1093/ndt/gfr195] [PMID: 21602180]

[230]
Meng FD, Li Y, Tian X, et al. Synergistic effects of snail and quercetin on renal cell carcinoma Caki-2 by altering AKT/mTOR/ERK1/2 signaling pathways. Int J Clin Exp Pathol  2015; 8(6): 6157-68.
 [PMID: 26261493]
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DOI https://dx.doi.org/10.2174/1573401319666230428152045	Print ISSN 1573-4013
Publisher Name Bentham Science Publisher	Online ISSN 2212-3881
Current Nutrition & Food Science

Quercetin: A Comprehensive Review

Abstract

Graphical Abstract

Bioactive compounds, functional foods, metabolism, and health

The Core Linkage Between Probiotics Encapsulation by the Natural Phytochemicals as Health and nutritional-related Functional Products: Recent Applications

Current Nutrition & Food Science

Quercetin: A Comprehensive Review

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Bioactive compounds, functional foods, metabolism, and health

The Core Linkage Between Probiotics Encapsulation by the Natural Phytochemicals as Health and nutritional-related Functional Products: Recent Applications

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