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ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

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Mini-Review Article

Tegoprazan as a New Remedy for Gastrointestinal Diseases in Comparison with its Therapeutic Predecessors: A Mini-Review

Author(s): Asif Hossain Anik*, Farhana Alam Proma, Pranoy Saha and Sabarni Sarker

Volume 16, Issue 1, 2024

Published on: 10 May, 2023

Page: [11 - 17] Pages: 7

DOI: 10.2174/2589977515666230428140741

Price: $65

Abstract

Potassium-competitive acid blockers (P-CABs), such as tegoprazan, are a new and diverse class of drugs that can completely block the potassium-binding site of gastric H+/K+ ATPase, potentially overcoming the limitations of proton-pump inhibitors (PPIs). A number of studies have compared the effectiveness as well as the safety profile of tegoprazan to PPIs and other P-CABs for the treatment of gastrointestinal diseases. The current review study evaluates the published works of literature related to clinical pharmacology and clinical trials of tegoprazan for the treatment of diseases related to the gastrointestinal tract. According to the publications included in the study, tegoprazan was found to be safe and well-tolerated and can be used to treat a group of gastrointestinal diseases, including gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), and H. pylori combination therapy.

Keywords: Tegoprazan, P-CABs, PPIs, gastrointestinal diseases, GERD, NERD, H. pylori.

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Graphical Abstract

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