Title:Serotonin and Depression: Scrutiny of New Targets for Future Anti-
Depressant Drug Development
Volume: 24
Issue: 10
关键词:
血清素,抑郁症,新靶点,病理生理学,血清素受体,大脑。
摘要: The “serotonin hypothesis of depression” is approximately fifty years old, and in spite
of vast literature, the exact role of serotonin in depression pathophysiology is still unclear, as
whether a lower serotonin level causes depression or depression causes a reduction in serotonin level
has become a tough challenge for researchers to understand the actual involvement of serotonin
in depression. Several pre-clinical and clinical studies have illustrated the multi-faceted signalling
action of serotonin in depression and vouch for the significant or unavoidable role of serotonin in
depression. In this review, the journey of the serotonin hypothesis of depression from the 1950s to
the present time has been analysed to understand the serotonin hypothesis of depression and investigate
the new molecular targets for the development of new future anti- depressants. The old and
new theories of possible cellular mechanisms found to be involved in the pathophysiology of major
depression or stress, such as polymorphism of serotonin transporters, enzyme modulating serotonergic
activity, reduction in the level of serotonin and involvement of different sub-types of receptors,
have been discussed in the respective review. Thus, in this review, the new signature targets to increase
serotonin levels have been identified, which would help the researcher in the drug development
of new faster-acting antidepressants.