Title:Hot Melt Extrusion: A Paradigm–Changing Technology
Volume: 17
Issue: 2
Author(s): Vaibhav G. Bhamare*Ravindra K. Kamble
Affiliation:
- Department of Pharmaceutics, K. K. Wagh College of Pharmacy, Maharashtra, India
Keywords:
Hot melt extrusion, amorphous solid, crystalline solid, glass transition temperature, extruder, drugs.
Abstract: Over the last few decades, hot melt extrusion (HME) has found extensive adaptability and
utility as a viable drug delivery option in the pharmaceutical industry. HME has already been validated
as a robust, novel technique mainly used for the correction of solubility and bioavailability of poorly
soluble drugs. In line with the scope of the current issue, this review appraises the value of HME as
a means of solubility enhancement of BCS class II drugs and presents an influential tool for the manufacturing
or production of drugs or chemicals. The drug development process can be shortened with
the use of hot melt extrusion technology, and the application of this process to analytical technology
can ease the manufacturing process. This review focuses on the tooling, utility, and manufacturing aspects
associated with hot melt extrusion technology.
