摘要
腺苷及其类似物在动物细胞中作为代谢过程的生物调节剂发挥重要作用,通过嘌呤能信号系统影响多种代谢功能。本文研究了一些已知的含手性取代基嘌呤核苷的合成及其构效关系。由于这些化合物对嘌呤能信号系统受体的选择性增强,它们作为靶向治疗癌症、代谢功能障碍和神经疾病的药物原型具有很大的潜力。含有手性取代基的腺苷和鸟苷衍生物也具有抗病毒活性。
关键词: 腺苷受体,嘌呤能信号,腺苷,手性,对映体,抗病毒,转糖基化,酶。
Current Medicinal Chemistry
Title:Purine Nucleosides and Analogues Bearing Chiral Substituents: Medicinal Chemistry and Therapeutic Perspective
Volume: 31 Issue: 6
关键词: 腺苷受体,嘌呤能信号,腺苷,手性,对映体,抗病毒,转糖基化,酶。
摘要: Adenosine and its analogues play an important role as bioregulators of metabolic processes in animal cells, affecting a variety of metabolic functions by acting through the purinergic signaling system. Synthesis and structure-activity relationship for some known purine nucleosides bearing chiral substituents are considered in this work. These compounds represent a promising potential as drug prototypes for targeted therapy of cancer, metabolic dysfunctions, and neuronal disorders due to their enhanced selectivity to receptors of the purinergic signaling system. Derivatives of adenosine and guanosine containing a chiral substituent also manifest antiviral activity.
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Cite this article as:
Purine Nucleosides and Analogues Bearing Chiral Substituents: Medicinal Chemistry and Therapeutic Perspective, Current Medicinal Chemistry 2024; 31 (6) . https://dx.doi.org/10.2174/0929867330666230420152130
DOI https://dx.doi.org/10.2174/0929867330666230420152130 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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