The Current Status and Future Direction of Extracellular Nano-vesicles in
the Alleviation of Skin Disorders

Raziyeh      Ghorbani; Simzar      Hosseinzadeh; Arezo      Azari; Niloofar      Taghipour; Masoud      Soleimani; Azam      Rahimpour; Hojjat   Allah   Abbaszadeh
doi:10.2174/1574888X18666230418121053
Abstract

Exosomes are extracellular vesicles (EVs) that originate from endocytic membranes. The transfer of biomolecules and biological compounds such as enzymes, proteins, RNA, lipids, and cellular waste disposal through exosomes plays an essential function in cell-cell communication and regulation of pathological and physiological processes in skin disease. The skin is one of the vital organs that makes up about 8% of the total body mass. This organ consists of three layers, epidermis, dermis, and hypodermis that cover the outer surface of the body. Heterogeneity and endogeneity of exosomes is an advantage that distinguishes them from nanoparticles and liposomes and leads to their widespread usage in the remedy of dermal diseases. The biocompatible nature of these extracellular vesicles has attracted the attention of many health researchers. In this review article, we will first discuss the biogenesis of exosomes, their contents, separation methods, and the advantages and disadvantages of exosomes. Then we will highlight recent developments related to the therapeutic applications of exosomes in the treatment of common skin disorders like atopic dermatitis, alopecia, epidermolysis bullosa, keloid, melanoma, psoriasis, and systemic sclerosis.
Keywords: Cell-free therapy, extracellular vesicles, ESCRT pathway, therapeutic nanovesicles, negative zeta potential, melanocytes.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1574888X18666230418121053	Print ISSN 1574-888X
Publisher Name Bentham Science Publisher	Online ISSN 2212-3946
Current Stem Cell Research & Therapy

The Current Status and Future Direction of Extracellular Nano-vesicles in the Alleviation of Skin Disorders

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