Title:Emerging Treatment Approaches for COVID-19 Infection: A Critical
Review
Volume: 24
Issue: 4
关键词:
多肽再利用，蛋白质组学，SARS-CoV-2，治疗学，转录组学，抗病毒药物。
摘要: In the present scenario, the SARS-CoV-2 virus has imposed enormous
damage on human survival and the global financial system. It has been estimated that
around 111 million people all around the world have been infected, and about 2.47
million people died due to this pandemic. The major symptoms were sneezing,
coughing, cold, difficulty breathing, pneumonia, and multi-organ failure associated 1with
SARS-CoV-2. Currently, two key problems, namely insufficient attempts to develop
drugs against SARSCoV-2 and the lack of any biological regulating process, are mostly
responsible for the havoc caused by this virus. Henceforth, developing a few novel drugs
is urgently required to cure this pandemic. It has been noticed that the pathogenesis of
COVID-19 is caused by two main events: infection and immune deficiency, that occur
during the pathological process. Antiviral medication can treat both the virus and the
host cells. Therefore, in the present review, the major approaches for the treatment have
been divided into "target virus" and "target host" groups. These two mechanisms
primarily rely on drug repositioning, novel approaches, and possible targets. Initially, we
discussed the traditional drugs per the physicians' recommendations. Moreover, such
therapeutics have no potential to fight against COVID-19. After that, detailed investigation
and analysis were conducted to find some novel vaccines and monoclonal
antibodies and conduct a few clinical trials to check their effectiveness against SARSCoV-
2 and mutant strains. Additionally, this study presents the most successful methods
for its treatment, including combinatorial therapy. Nanotechnology was studied to build
efficient nanocarriers to overcome the traditional constraints of antiviral and biological
therapies.
