Title:Review on In-vitro Techniques and In-vivo Animals Models for Screening
Diabetes and Diabetic Complications
Volume: 20
Issue: 1
Author(s): Shivam*, Sushil Kumar and Asheesh Kumar Gupta
Affiliation:
- School of Pharmaceutical Sciences, IFTM University, Delhi Road, NH-24 Moradabad, Lodhipur Rajpoot,
Uttar Pradesh, 244102, India
Keywords:
Diabetes mellitus, microvascular, complications, metabolic disorders, animal models, in vitro techniques.
Abstract: Diabetes mellitus is a type of metabolic disorders. Various pharmaceutical interventions
and animal models have been used to investigate the genetic, environmental, and etiological aspects
of diabetes and its effects. In recent years for the development of ant-diabetic remedies, numerous
novel genetically modified animals, pharmaceutical substances, medical techniques, viruses,
and hormones have been developed to screen diabetic complications. A unique disease-treating
drug with new properties is still being sought after. The current review tried to include all published
models and cutting-edge techniques. Experimental induction of diabetes mellitus in animal
models and in vitro methods are essential for advancing our knowledge, a thorough grasp of pathophysiology,
and the creation of novel therapeutics. Animal models and in vitro techniques are necessary
to develop innovative diabetic medications. New approaches and additional animal models
are required for diabetes research to advance. This is particularly true for models produced via dietary
modifications, which have various macronutrient compositions. In this article, we review the
rodent models of diet-induced diabetic peripheral neuropathy, diabetic retinopathy, and diabetic
nephropathy and critically compare the key characteristics of these micro-vascular complications
in humans and the diagnostic criteria with the parameters used in preclinical research using rodent
models, taking into consideration the potential need for factors that can accelerate or aggravate these
conditions.
