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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

Molecular Milieu of Autophagy in Cervical Cancer and its Therapeutic Implications

Author(s): Sneha O. Pathak and Sonal M. Manohar*

Volume 23, Issue 11, 2023

Published on: 17 May, 2023

Page: [843 - 857] Pages: 15

DOI: 10.2174/1568009623666230412104913

Price: $65

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Abstract

Cervical cancer is a common death-causing cancer among women in developing countries. Majority of the cases are triggered by persistent infections with high-risk Human Papillomavirus (HPV16 and 18). Metastasis, disease relapse, and drug resistance are common among patients in advanced stages of cancer despite the available therapies. Consequently, new prospective targets are needed for this disease. Autophagy is professed to have implications in cervical cancer progression as well as cancer dormancy. This article reviews the role of autophagy in cervical cancer progression and the modulation of the autophagy pathway by HPV. Further, various therapeutic agents that target autophagy in cervical cancer are discussed.

Keywords: Autophagy, cervical cancer, human papillomavirus, resistance to apoptosis, anticancer therapy, signaling pathways.

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