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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Synthesis of 1,4-Benzodiazepines by Palladium-Catalyzed C-N Coupling

Author(s): Pranshu Bhardwaj and Navjeet Kaur*

Volume 27, Issue 4, 2023

Published on: 12 May, 2023

Page: [282 - 296] Pages: 15

DOI: 10.2174/1385272827666230412080929

Price: $65

Abstract

1,4-benzodiazepines play a valuable role in organic and medicinal chemistry. In this review article, we have mainly discussed the synthesis of various 1,4-benzodiazepines in the presence of a palladium catalyst. Different reactions, such as intramolecular N-arylation, reductive elimination, oxidative addition, intramolecular alkylation, C-H activation, aryl-aryl bond formation, etc., are included. For these types of syntheses, an easy and efficient catalytic domino process has been reported, including the intermolecular or intramolecular reactions. In this review article, we have also discussed catalyst regeneration and some ligand-free Pdcatalyzed reactions.

Keywords: 1, 4-Diazepine, 1, 4-benzodiazepine, palladium catalyst, C-N coupling, domino reaction, heterocyclic compounds.

Graphical Abstract
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