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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Review Article

Intramolecular Click Cycloaddition Reactions: Synthesis of 1,2,3-Triazoles

Author(s): Zahra Tashrifi, Mohammad Mohammadi Khanaposhtani, Saeed Bahadorikhalili, Bagher Larijani and Mohammad Mahdavi*

Volume 21, Issue 2, 2024

Published on: 09 June, 2023

Page: [166 - 194] Pages: 29

DOI: 10.2174/1570179420666230407103320

Price: $65


Click Chemistry, as a powerful tool, has been used for the synthesis of a variety of 1,2,3-triazoles. Among click cycloaddition reactions, intramolecular click reactions carried out in azido-alkyne precursors has not been thoroughly reviewed. Hence, in this review, we have summarized and categorised the recent literature (from 2012 on) based on the azidoalkynyl precursor's type and a brief and concise description of the involved mechanisms is presented. Accordingly, we have classified the relevant literature into three categories: (1) substitution precursors (2) addition and (3) multi-component reaction (MCR) products.

Keywords: Intramolecular click reactions, cycloaddition, azido-alkynes, triazole, click chemistry, substitution precursors, MCR.

Graphical Abstract
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