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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Review Article

Sexual Dysfunction in Diabetic Patients: Τhe Role of Advanced Glycation End Products

Author(s): Μelpomeni Peppa* and Aspasia Manta

Volume 20, Issue 2, 2024

Published on: 24 May, 2023

Article ID: e070423215531 Pages: 9

DOI: 10.2174/1573399819666230407095522

Price: $65

Abstract

Sexual dysfunction is a common but underestimated disorder of diabetic patients of both genders, entailing specific and complex pathogenesis and severely affecting reproductive health and quality of life. Hyperglycemia, dyslipidemia, hypertension, obesity, aging, and psychological factors underlie its pathogenesis. A large body of evidence indicates that advanced glycation end products and oxidative stress have a distinct impact on the pathogenesis of diabetes and its complications, including hypogonadism, which is closely related to sexual dysfunction. Advanced glycation end products seem to affect sexual function either directly by accumulation in various regions of the reproductive system and/or correlation or indirectly through oxidative stress induction via several mechanisms. They are also involved in the pathogenesis of diabetic complications, which are related to sexual dysfunction. Herein, we review the issue of sexual dysfunction in diabetic males and females, with special emphasis on the impact of advanced glycation end products in the pathogenesis of sexual dysfunction, the relationship of advanced glycation end products with low testosterone levels in diabetic subjects, which account for the proportion of disorder and the available therapeutic interventions.

Keywords: Sexual dysfunction, advanced glycation end products, AGE, oxidative stress, male hypogonadism, female hypogonadism, testosterone, diabetes mellitus, polycystic ovary syndrome, diet.

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