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Anti-Cancer Agents in Medicinal Chemistry

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ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

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Review Article

Natural Products and Gastric Cancer: Cellular Mechanisms and Effects to Change Cancer Progression

Author(s): Ning Zhao, Wendi Wang, Haoyue Jiang, Zhengkang Qiao, Shiming Sun, Yang Wei, Xinru Xie, Hui Li*, Xiuli Bi* and Zhe Yang*

Volume 23, Issue 13, 2023

Published on: 09 May, 2023

Page: [1506 - 1518] Pages: 13

DOI: 10.2174/1871520623666230407082955

Price: $65

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Abstract

Gastric cancer is a severe malignant tumor with high morbidity and mortality, which seriously affects people’s health. At present, the most common treatment for gastric cancer is chemotherapy. However, chemotherapy is very harmful to the human body, and some of the injuries caused by chemotherapy are irreversible. Natural products have low toxicity and anti-cancer activity, so they are currently widely studied at present. Natural products are a large variety of compounds naturally found in fruits, vegetables, spices, and medicinal plants. It is reported that natural products have different anti-cancer properties. This review has summarized the study of natural products in inducing gastric cancer cell apoptosis, inhibiting gastric cancer cell metastasis, and inhibiting gastric cancer cell proliferation. The relevant references on gastric cancer and natural products were obtained from scientific databases, including Pub- Med, Web of Science, and Science Direct. This paper records dozens of natural products with anti-gastric tumor activity and describes the potential living anti-cancer chemical compounds, their element targets, and their underlying mechanism. This review may lay the foundation for future researchers to treat gastric cancer.

Keywords: Gastric cancer, natural products, anti-cancerous effects, signaling pathways, anti-oxidant function, anti-proliferative function, anti-inflammatory activity.

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