Title:Effect of Apigenin on Neurodegenerative Diseases
Volume: 23
Issue: 4
Author(s): Kajal Gaur and Yasir Hasan Siddique*
Affiliation:
- Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India
Keywords:
Apigenin, neurodegenerative disease, reactive oxygen species, oxidative stress, antioxidant, reactive oxygen species (ROS).
Abstract: Neurodegenerative diseases (NDDs), such as Alzheimer's and Parkinson's, are the most frequent
age-related illnesses affecting millions worldwide. No effective medication for NDDs is known
to date and current disease management approaches include neuroprotection strategies with the hope
of maintaining and improving the function of neurons. Such strategies will not provide a cure on their
own but are likely to delay disease progression by reducing the production of neurotoxic chemicals
such as reactive oxygen species (ROS) and related inflammatory chemicals. Natural compounds such
as flavonoids that provide neuroprotection via numerous mechanisms have attracted much attention in
recent years. This review discusses evidence from different research models and clinical trials on the
therapeutic potential of one promising flavonoid, apigenin, and how it can be helpful for NDDs in the
future prospects. We have also discussed its chemistry, mechanism of action, and possible benefits in
various examples of NDDs.
