Title:Delayed Wound Healing in the Elderly and a New Therapeutic Target:
CD271
Volume: 19
Issue: 3
Author(s): Hongqing Zhao, Sirui Fan and Jiachen Sun*
Affiliation:
- Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China
Keywords:
CD271, P75NTR, epidermal stem cells, wound healing, tumor necrosis factor receptors, brain-derived neurotrophic factor.
Abstract: With the development of society, the global population is showing a trend of aging. It is well
known that age is one of the factors affecting wound healing. Aging compromises the normal physiological
process of wound healing, such as the change of skin structure, the decrease of growth factors, the
deceleration of cell proliferation, and the weakening of migration ability, hence delaying wound healing.
At present, research in adult stem cell-related technology and its derived regenerative medicine provides a
novel idea for the treatment of senile wounds. Studies have confirmed that CD271 (P75 neurotropism
receptor/P75NTR)-positive cells (CD271+ cells) are a kind of stem cells with a stronger ability of proliferation,
differentiation, migration and secretion than CD271 negative (CD271- cells). Meanwhile, the total
amount and distribution of CD271 positive cells in different ages of skin are also different, which may be
related to the delayed wound healing of aging skin. Therefore, this article reviews the relationship between
CD271+ cells and senile wounds and discusses a new scheme for the treatment of senile wounds.