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Current Drug Research Reviews

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ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

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Review Article

Biological Importance, Pharmacological Activities, and Nutraceutical Potential of Capsanthin: A Review of Capsicum Plant Capsaicinoids

Author(s): Kanika Patel and Dinesh Kumar Patel*

Volume 16, Issue 1, 2024

Published on: 19 April, 2023

Page: [18 - 31] Pages: 14

DOI: 10.2174/2589977515666230331093712

Price: $65

Abstract

Background: Carotenoids are natural hydrocarbons that play an important role in photomorphogenesis, photosynthesis, photoprotection, development, and defense mechanism of plants. Carotenoids have good anti-oxidants and provitamin A contents with their additional colorant nature, which are indispensable to plants and human diets. Capsicum species are well known for their culinary uses worldwide; they are not only cultivated as vegetables but used in numerous medicinal preparations as well due to their medicinal aspects. This article aims to collect data on the beneficial aspects of capsaicinoids with a major emphasis on capsanthin.

Methods: In order to investigate the biological potential and therapeutic benefit of capsanthin in medicine, in the present work, scientific research data on capsanthin were collected from different literature sources and analyzed. The biological potential of Capsicum annuum in medicine was also investigated through literature data analysis of different scientific research work. Scientific data on capsanthin were collected from Google, Google Scholar, PubMed, Science Direct, and Scopus using the term capsanthin and capsicum in the present work. Detailed pharmacological activities of capsanthin were presented and discussed in the present work through scientific data analysis of research work. Analytical techniques for the separation, isolation, and identification of capsanthin were taken into consideration in this work.

Results: Scientific data analysis revealed the biological importance and therapeutic benefit of capsanthin and capsicum in medicine. Capsicum annuum is a member of the Solanaceae family, which is one of the most cultivated spices worldwide. Capsaicinoids are one of the main classes of phytochemicals found in chili peppers, i.e., Capsicum annuum, and are mainly responsible for the pungent and spicy flavor of chili peppers. Capsanthin is a crystalline red color pigment found as the main component of Capsicum annuum fruits during ripening. Capsanthin is also found in Lilium, Aesculus, Berberis, and Asparagus officinalis. Chemically, capsanthin contains a cyclopentane ring, 11 conjugated double bonds, and a conjugated keto group. Capsanthin is a powerful antioxidant, exhibits anti-tumor activities, attenuates obesity-induced inflammation, and raises plasma HDL cholesterol levels. Scientific studies have proven the pharmacological benefits of capsanthin in medicine as it is helpful in pain relief, cardioprotection, weight loss, and body temperature regulation. Moreover, it also has anti-inflammatory, anticancer, antioxidant, and antimicrobial activities. In the literature database, numerous extraction and isolation techniques have been documented for capsanthin. In addition, the analytical techniques and other bioanalytical tools for the isolation and identification of capsanthin were also discussed in the present article.

Conclusion: Medicinal importance and pharmacological activities of capsanthin were reviewed and discussed in this paper. This review aimed to highlight the literature on capsanthin in drug discoveries with their analytical development.

Keywords: Capsaicinoid, capsanthin, capsicum annuum, capsicum, carotenoid, medicinal importance, pharmacological activities, analytical techniques.

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[1]
Patel K, Patel DK. Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report. J Tradit Complement Med 2017; 7(3): 360-6.
[http://dx.doi.org/10.1016/j.jtcme.2016.11.003] [PMID: 28725632]
[2]
Patel K, Kumar V, Rahman M, Verma A, Patel DK. Rhamnazin: A systematic review on ethnopharmacology, pharmacology and analytical aspects of an important phytomedicine. Curr Tradit Med 2018; 4(2): 120-7.
[http://dx.doi.org/10.2174/2215083804666180416124949]
[3]
Patel K, Patel DK. Medicinal significance, pharmacological activities, and analytical aspects of ricinine: A concise report. J Coast Life Med 2016; 4(8): 663-7.
[http://dx.doi.org/10.12980/jclm.4.2016J6-96]
[4]
Patel K, Mishra R, Patel DK. A review on phytopharmaceutical importance of asiaticoside. J Coast Life Med 2016; 4(12): 1000-7.
[http://dx.doi.org/10.12980/jclm.4.2016J6-161]
[5]
Wahyuni Y, Ballester AR, Sudarmonowati E, Bino RJ, Bovy AG. Metabolite biodiversity in pepper (Capsicum) fruits of thirty-two diverse accessions: Variation in health-related compounds and implications for breeding. Phytochemistry 2011; 72(11-12): 1358-70.
[http://dx.doi.org/10.1016/j.phytochem.2011.03.016] [PMID: 21514607]
[6]
Meghvansi MK, Siddiqui S, Khan MH, et al. Naga chilli: A potential source of capsaicinoids with broad-spectrum ethnopharmacological applications. J Ethnopharmacol 2010; 132(1): 1-14.
[http://dx.doi.org/10.1016/j.jep.2010.08.034] [PMID: 20728519]
[7]
Menichini F, Tundis R, Bonesi M, et al. The influence of fruit ripening on the phytochemical content and biological activity of Capsicum chinense Jacq. cv Habanero. Food Chem 2009; 114(2): 553-60.
[http://dx.doi.org/10.1016/j.foodchem.2008.09.086]
[8]
Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite 2012; 59(2): 341-8.
[http://dx.doi.org/10.1016/j.appet.2012.05.015] [PMID: 22634197]
[9]
Majee SK, Ray S, Ghosh K, Micard V, Ray B. Isolation and structural features of an antiradical polysaccharide of Capsicum annuum that interacts with BSA. Int J Biol Macromol 2015; 75: 144-51.
[http://dx.doi.org/10.1016/j.ijbiomac.2015.01.024] [PMID: 25616119]
[10]
Gurnani N, Gupta M, Mehta D, Mehta BK. Chemical composition, total phenolic and flavonoid contents, and in vitro antimicrobial and antioxidant activities of crude extracts from red chilli seeds (Capsicum frutescens L.). J Taibah Univ Sci 2016; 10(4): 462-70.
[http://dx.doi.org/10.1016/j.jtusci.2015.06.011]
[11]
Dong X, Li X, Ding L, Cui F, Tang Z, Liu Z. Stage extraction of capsaicinoids and red pigments from fresh red pepper (Capsicum) fruits with ethanol as solvent. Lebensm Wiss Technol 2014; 59(1): 396-402.
[http://dx.doi.org/10.1016/j.lwt.2014.04.051]
[12]
Loizzo MR, Pugliese A, Bonesi M, Menichini F, Tundis R. Evaluation of chemical profile and antioxidant activity of twenty cultivars from Capsicum annuum, Capsicum baccatum, Capsicum chacoense and Capsicum chinense: A comparison between fresh and processed peppers. Lebensm Wiss Technol 2015; 64(2): 623-31.
[http://dx.doi.org/10.1016/j.lwt.2015.06.042]
[13]
Sung J, Bang MH, Lee J. Bioassay-guided isolation of anti-adipogenic compounds from defatted pepper (Capsicum annuum L.) seeds. J Funct Foods 2015; 14: 670-5.
[http://dx.doi.org/10.1016/j.jff.2015.02.043]
[14]
Fernández-Bedmar Z, Alonso-Moraga A. In vivo and in vitro evaluation for nutraceutical purposes of capsaicin, capsanthin, lutein and four pepper varieties. Food Chem Toxicol 2016; 98(Pt B): 89-90.
[15]
Kulkarni M, Phalke S. Evaluating variability of root size system and its constitutive traits in hot pepper (Capsicum annum L.) under water stress. Sci Hortic (Amsterdam) 2009; 120(2): 159-66.
[http://dx.doi.org/10.1016/j.scienta.2008.10.007]
[16]
Kim JS, An CG, Park JS, Lim YP, Kim S. Carotenoid profiling from 27 types of paprika (Capsicum annuum L.) with different colors, shapes, and cultivation methods. Food Chem 2016; 201: 64-71.
[http://dx.doi.org/10.1016/j.foodchem.2016.01.041] [PMID: 26868549]
[17]
Barbero GF, Ruiz AG, Liazid A, Palma M, Vera JC, Barroso CG. Evolution of total and individual capsaicinoids in peppers during ripening of the Cayenne pepper plant (Capsicum annuum L.). Food Chem 2014; 153: 200-6.
[http://dx.doi.org/10.1016/j.foodchem.2013.12.068] [PMID: 24491721]
[18]
da Silveira Agostini-Costa T, da Silva Gomes I, de Melo LAMP, Reifschneider FJB, da Costa Ribeiro CS. Carotenoid and total vitamin C content of peppers from selected Brazilian cultivars. J Food Compos Anal 2017; 57: 73-9.
[http://dx.doi.org/10.1016/j.jfca.2016.12.020]
[19]
Romo-Hualde A, Yetano-Cunchillos AI, González-Ferrero C, Sáiz-Abajo MJ, González-Navarro CJ. Supercritical fluid extraction and microencapsulation of bioactive compounds from red pepper (Capsicum annum L.) by-products. Food Chem 2012; 133(3): 1045-9.
[http://dx.doi.org/10.1016/j.foodchem.2012.01.062]
[20]
Gómez-García M, Ochoa-Alejo N. Biochemistry and molecular biology of carotenoid biosynthesis in chili peppers (Capsicum spp.). Int J Mol Sci 2013; 14(9): 19025-53.
[http://dx.doi.org/10.3390/ijms140919025] [PMID: 24065101]
[21]
Bae H, Jayaprakasha GK, Jifon J, Patil BS. Variation of antioxidant activity and the levels of bioactive compounds in lipophilic and hydrophilic extracts from hot pepper (Capsicum spp.) cultivars. Food Chem 2012; 134(4): 1912-8.
[http://dx.doi.org/10.1016/j.foodchem.2012.03.108] [PMID: 23442638]
[22]
Nishino H, Murakoshi M, Ii T, et al. Carotenoids in cancer chemoprevention. Cancer Metastasis Rev 2002; 21(3/4): 257-64.
[http://dx.doi.org/10.1023/A:1021206826750] [PMID: 12549764]
[23]
Mori T, Ohnishi M, Komiyama M, Tsutsui A, Yabushita H, Okada H. Growth inhibitory effect of paradicsompaprika in cancer cell lines. Oncol Rep 2002; 9(4): 807-10.
[http://dx.doi.org/10.3892/or.9.4.807] [PMID: 12066213]
[24]
Niu FX, Lu Q, Bu YF, Liu JZ. Metabolic engineering for the microbial production of isoprenoids: Carotenoids and isoprenoid-based biofuels. Synth Syst Biotechnol 2017; 2(3): 167-75.
[http://dx.doi.org/10.1016/j.synbio.2017.08.001] [PMID: 29318197]
[25]
Giuffrida D, Dugo P, Torre G, et al. Evaluation of carotenoid and capsaicinoid contents in powder of red chili peppers during one year of storage. Food Res Int 2014; 65: 163-70.
[http://dx.doi.org/10.1016/j.foodres.2014.06.019]
[26]
Sankari M, Rao PR, Hemachandran H, et al. Prospects and progress in the production of valuable carotenoids: Insights from metabolic engineering, synthetic biology, and computational approaches. J Biotechnol 2018; 266: 89-101.
[http://dx.doi.org/10.1016/j.jbiotec.2017.12.010] [PMID: 29247672]
[27]
Hassan M, Oberg G, Bekassy AN, et al. Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology. Cancer Chemother Pharmacol 1991; 28(2): 130-4.
[http://dx.doi.org/10.1007/BF00689702] [PMID: 2060084]
[28]
Park HS, Chung JW, Jae HJ, et al. FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model. Korean J Radiol 2007; 8(3): 216-24.
[http://dx.doi.org/10.3348/kjr.2007.8.3.216] [PMID: 17554189]
[29]
Eggersdorfer M, Wyss A. Carotenoids in human nutrition and health. Arch Biochem Biophys 2018; 652: 18-26.
[http://dx.doi.org/10.1016/j.abb.2018.06.001] [PMID: 29885291]
[30]
Bajer T, Bajerová P, Kremr D, Eisner A, Ventura K. Central composite design of pressurised hot water extraction process for extracting capsaicinoids from chili peppers. J Food Compos Anal 2015; 40: 32-8.
[http://dx.doi.org/10.1016/j.jfca.2014.12.008]
[31]
Urbina SL, Roberts MD, Kephart WC, et al. Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals. Appetite 2017; 113: 264-73.
[http://dx.doi.org/10.1016/j.appet.2017.02.025] [PMID: 28235621]
[32]
Chan KK, Hamid MSB, Webster RD. Quantification of capsaicinoids in chillies by solid-phase extraction coupled with voltammetry. Food Chem 2018; 265: 152-8.
[http://dx.doi.org/10.1016/j.foodchem.2018.05.069] [PMID: 29884366]
[33]
Islam MA, Sharma SS, Sinha P, Negi MS, Neog B, Tripathi SB. Variability in capsaicinoid content in different landraces of Capsicum cultivated in north-eastern India. Sci Hortic (Amsterdam) 2015; 183: 66-71.
[http://dx.doi.org/10.1016/j.scienta.2014.12.011]
[34]
Stipcovich T, Barbero GF, Ferreiro-González M, Palma M, Barroso CG. Fast analysis of capsaicinoids in Naga Jolokia extracts (Capsicum chinense) by high-performance liquid chromatography using fused core columns. Food Chem 2018; 239: 217-24.
[http://dx.doi.org/10.1016/j.foodchem.2017.06.098] [PMID: 28873562]
[35]
Narisawa T, Fukaura Y, Hasebe M, Nomura S, Oshima S, Inakuma T. Prevention of N-methylnitrosourea-induced colon carcinogenesis in rats by oxygenated carotenoid capsanthin and capsanthin-rich paprika juice. Proc Soc Exp Biol Med 2000; 224(2): 116-22.
[http://dx.doi.org/10.1046/j.1525-1373.2000.22409.x] [PMID: 10806419]
[36]
Molnár J, Gyémánt N, Mucsi I, et al. Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids. In Vivo 2004; 18(2): 237-44.
[PMID: 15113052]
[37]
Wang Q, Michalak K, Wesolowska O, et al. Reversal of multidrug resitance by natural substances from plants. Curr Top Med Chem 2010; 10(17): 1757-68.
[http://dx.doi.org/10.2174/156802610792928103] [PMID: 20645919]
[38]
Molnár J, Serly J, Pusztai R, et al. Putative supramolecular complexes formed by carotenoids and xanthophylls with ascorbic acid to reverse multidrug resistance in cancer cells. Anticancer Res 2012; 32(2): 507-17.
[PMID: 22287739]
[39]
Zhang X, Zhao W, Hu L, Zhao L, Huang J. Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells. Arch Biochem Biophys 2011; 512(1): 96-106.
[http://dx.doi.org/10.1016/j.abb.2011.05.004] [PMID: 21620794]
[40]
Maoka T, Mochida K, Kozuka M, et al. Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L. Cancer Lett 2001; 172(2): 103-9.
[http://dx.doi.org/10.1016/S0304-3835(01)00635-8] [PMID: 11566483]
[41]
Medvedeva NVAV, Andreenkov VA, Morozkin AD, Sergeeva EA, Prokof’ev IuI, Misharin AIu. Inhibition of oxidation of human blood low density lipoproteins by carotenoids from paprika. Biomed Khim 2003; 49(2): 191-200.
[PMID: 14565083]
[42]
Jo SJ, Kim JW, Choi HO, et al. Capsanthin inhibits both adipogenesis in 3T3-L1 preadipocytes and weight gain in high-fat diet-induced obese mice. Biomol Ther (Seoul) 2017; 25(3): 329-36.
[http://dx.doi.org/10.4062/biomolther.2017.048] [PMID: 28449555]
[43]
Aizawa K, Inakuma T. Dietary capsanthin, the main carotenoid in paprika (Capsicum annuum), alters plasma high-density lipoprotein-cholesterol levels and hepatic gene expression in rats. Br J Nutr 2009; 102(12): 1760-6.
[http://dx.doi.org/10.1017/S0007114509991309] [PMID: 19646292]
[44]
Zhang J, Hou X, Ahmad H, Zhang H, Zhang L, Wang T. Assessment of free radicals scavenging activity of seven natural pigments and protective effects in AAPH-challenged chicken erythrocytes. Food Chem 2014; 145: 57-65.
[http://dx.doi.org/10.1016/j.foodchem.2013.08.025] [PMID: 24128449]
[45]
Kim JS, Lee WM, Rhee HC, Kim S. Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communication. Chem Biol Interact 2016; 254: 146-55.
[http://dx.doi.org/10.1016/j.cbi.2016.05.004] [PMID: 27154496]
[46]
Le Grandois J, Guffond D, Hamon E, Marchioni E, Werner D. Combined microplate-ABTS and HPLC-ABTS analysis of tomato and pepper extracts reveals synergetic and antagonist effects of their lipophilic antioxidative components. Food Chem 2017; 223: 62-71.
[http://dx.doi.org/10.1016/j.foodchem.2016.12.008] [PMID: 28069124]
[47]
Sun T, Xu Z, Wu CT, Janes M, Prinyawiwatkul W, No HK. Antioxidant activities of different colored sweet bell peppers (Capsicum annuum L.). J Food Sci 2007; 72(2): S98-S102.
[http://dx.doi.org/10.1111/j.1750-3841.2006.00245.x] [PMID: 17995862]
[48]
Maeda H, Saito S, Nakamura N, Maoka T. Paprika pigments attenuate obesity-induced inflammation in 3T3-L1 adipocytes. ISRN Inflamm 2013; 2013: 1-9.
[http://dx.doi.org/10.1155/2013/763758] [PMID: 24049664]
[49]
Horie S, Okuda C, Yamashita T, et al. Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response. Lipids 2010; 45(8): 713-21.
[http://dx.doi.org/10.1007/s11745-010-3449-5] [PMID: 20669052]
[50]
Jávor T, Bata M, Lovász L, et al. Gastric cytoprotective effects of vitamin A and other carotenoids. Int J Tissue React 1983; 5(3): 289-96.
[PMID: 6654625]
[51]
Kars MD, İşeri OD, Gunduz U, Molnar J. Reversal of multidrug resistance by synthetic and natural compounds in drug-resistant MCF-7 cell lines. Chemotherapy 2008; 54(3): 194-200.
[http://dx.doi.org/10.1159/000140462] [PMID: 18560226]
[52]
Sako F, Kobayashi N, Taniguchi N, Takakuwa E. A study on the toxicity of natural food dyes-toxicity and enzyme inhibition in Paramecium caudatum. J Toxicol Sci 1978; 3(2): 127-36.
[http://dx.doi.org/10.2131/jts.3.127] [PMID: 39176]
[53]
Oshima S, Sakamoto H, Ishiguro Y, Terao J. Accumulation and clearance of capsanthin in blood plasma after the ingestion of paprika juice in men. J Nutr 1997; 127(8): 1475-9.
[http://dx.doi.org/10.1093/jn/127.8.1475]
[54]
Etoh H, Utsunomiya Y, Komori A, Murakami Y, Oshima S, Inakuma T. Carotenoids in human blood plasma after ingesting paprika juice. Biosci Biotechnol Biochem 2000; 64(5): 1096-8.
[http://dx.doi.org/10.1271/bbb.64.1096] [PMID: 10879492]
[55]
Umigai N, Murakami K, Shimizu R, Takeda R, Azuma T. Safety evaluation and plasma carotenoid accumulation in healthy adult subjects after 12 weeks of paprika oleoresin supplementation. J Oleo Sci 2018; 67(2): 225-34.
[http://dx.doi.org/10.5650/jos.ess17155] [PMID: 29367485]
[56]
Nishino A, Ichihara T, Takaha T, et al. Accumulation of paprika carotenoids in human plasma and erythrocytes. J Oleo Sci 2015; 64(10): 1135-42.
[http://dx.doi.org/10.5650/jos.ess15118] [PMID: 26369598]
[57]
Pérez-Gálvez A, Martin HD, Sies H, Stahl W. Incorporation of carotenoids from paprika oleoresin into human chylomicrons. Br J Nutr 2003; 89(6): 787-93.
[http://dx.doi.org/10.1079/BJN2003842] [PMID: 12828795]
[58]
Morais H, Rodrigues P, Ramos C, Forgács E, Cserháti T, Oliveira J. Effect of ascorbic acid on the stability of beta-carotene and capsanthin in paprika (Capsicum annuum) powder. Nahrung 2002; 46(5): 308-10.
[http://dx.doi.org/10.1002/1521-3803(20020901)46:5<308:AID-FOOD308>3.0.CO;2-B] [PMID: 12428443]
[59]
Fernández-García E, Carvajal-Lérida I, Pérez-Gálvez A. Carotenoids exclusively synthesized in red pepper (capsanthin and capsorubin) protect human dermal fibroblasts against UVB induced DNA damage. Photochem Photobiol Sci 2016; 15(9): 1204-11.
[http://dx.doi.org/10.1039/c6pp00134c] [PMID: 27537377]
[60]
Nishino M, Sakata M, Murata Y, Nakamura Y. Lower photostability of capsanthin dispersed in an aqueous solution. Biosci Biotechnol Biochem 2013; 77(6): 1313-6.
[http://dx.doi.org/10.1271/bbb.130033] [PMID: 23748767]
[61]
Ha SH, Kim JB, Park JS, Lee SW, Cho KJ. A comparison of the carotenoid accumulation in Capsicum varieties that show different ripening colours: deletion of the capsanthin-capsorubin synthase gene is not a prerequisite for the formation of a yellow pepper. J Exp Bot 2007; 58(12): 3135-44.
[http://dx.doi.org/10.1093/jxb/erm132] [PMID: 17728301]
[62]
Santos L, Kasper R, Sardiñas N, Marín S, Sanchis V, Ramos AJ. Effect of Capsicum carotenoids on growth and aflatoxins production by Aspergillus flavus isolated from paprika and chilli. Food Microbiol 2010; 27(8): 1064-70.
[http://dx.doi.org/10.1016/j.fm.2010.07.010] [PMID: 20832686]
[63]
Wang SB, Tian SL, Shah SNM, Pan BG, Diao WP, Gong ZH. Cloning and characterization of the CarbcL gene related to chlorophyll in pepper (Capsicum annuum L.) under fruit shade stress. Front Plant Sci 2015; 6: 850.
[http://dx.doi.org/10.3389/fpls.2015.00850] [PMID: 26528313]
[64]
Tian SL, Li L, Chai WG, Shah SNM, Gong ZH. Effects of silencing key genes in the capsanthin biosynthetic pathway on fruit color of detached pepper fruits. BMC Plant Biol 2014; 14(1): 314.
[http://dx.doi.org/10.1186/s12870-014-0314-3] [PMID: 25403855]
[65]
Spezia R, Knecht S, Mennucci B. Excited state characterization of carbonyl containing carotenoids: A comparison between single and multireference descriptions. Phys Chem Chem Phys 2017; 19(26): 17156-66.
[http://dx.doi.org/10.1039/C7CP02941A] [PMID: 28636682]
[66]
Scholz M, Flender O, Lenzer T, Oum K. Ultrafast excited-state dynamics of all-trans -Capsanthin in organic solvents. J Phys Chem A 2017; 121(44): 8380-8.
[http://dx.doi.org/10.1021/acs.jpca.7b08252] [PMID: 29090578]
[67]
Wang J, Fang XM, Mujumdar AS, et al. Effect of high-humidity hot air impingement blanching (HHAIB) on drying and quality of red pepper (Capsicum annuum L.). Food Chem 2017; 220: 145-52.
[http://dx.doi.org/10.1016/j.foodchem.2016.09.200] [PMID: 27855882]
[68]
Murillo E, Turcsi E, Szabó I, et al. Carotenoid composition of the fruit of red mamey (Pouteria sapota). J Agric Food Chem 2016; 64(38): 7148-55.
[http://dx.doi.org/10.1021/acs.jafc.6b03146] [PMID: 27598884]
[69]
Nishino A, Yasui H, Maoka T. Reaction of paprika carotenoids, capsanthin and capsorubin, with reactive oxygen species. J Agric Food Chem 2016; 64(23): 4786-92.
[http://dx.doi.org/10.1021/acs.jafc.6b01706] [PMID: 27229653]
[70]
Peng D, Liao F, Pan Y, et al. Development a monoclonal antibody-based enzyme-linked immunosorbent assay for screening carotenoids in eggs. Food Chem 2016; 202: 141-8.
[http://dx.doi.org/10.1016/j.foodchem.2016.01.123] [PMID: 26920278]
[71]
Chow PY, Gue SZ, Leow SK, Goh LB. The bioefficacy of microemulsified natural pigments in egg yolk pigmentation. Br Poult Sci 2014; 55(3): 398-402.
[http://dx.doi.org/10.1080/00071668.2014.918583] [PMID: 24783946]
[72]
Brulc L, Simonovska B, Vovk I, Glavnik V. Determination of egg yolk xanthophylls by isocratic high-performance liquid chromatography. J Chromatogr A 2013; 1318: 134-41.
[http://dx.doi.org/10.1016/j.chroma.2013.09.074] [PMID: 24139505]
[73]
Pugliese A, Loizzo MR, Tundis R, et al. The effect of domestic processing on the content and bioaccessibility of carotenoids from chili peppers (Capsicum species). Food Chem 2013; 141(3): 2606-13.
[http://dx.doi.org/10.1016/j.foodchem.2013.05.046] [PMID: 23871001]
[74]
Pugliese A, O’Callaghan Y, Tundis R, et al. In vitro investigation of the bioaccessibility of carotenoids from raw, frozen and boiled red chili peppers (Capsicum annuum). Eur J Nutr 2014; 53(2): 501-10.
[http://dx.doi.org/10.1007/s00394-013-0555-1] [PMID: 23820691]
[75]
Shim YS, Kim KJ, Seo D, et al. Simultaneous determination of free capsorubin and capsanthin in red pepper powder using u-HPLC. J AOAC Int 2013; 96(2): 341-5.
[http://dx.doi.org/10.5740/jaoacint.12-179] [PMID: 23767359]
[76]
Wang YQ, Yang Y, Fei Z, et al. Proteomic analysis of chromoplasts from six crop species reveals insights into chromoplast function and development. J Exp Bot 2013; 64(4): 949-61.
[http://dx.doi.org/10.1093/jxb/ers375] [PMID: 23314817]
[77]
Mitrowska K, Vincent U, von Holst C. Separation and quantification of 15 carotenoids by reversed phase high performance liquid chromatography coupled to diode array detection with isosbestic wavelength approach. J Chromatogr A 2012; 1233: 44-53.
[http://dx.doi.org/10.1016/j.chroma.2012.01.089] [PMID: 22377469]
[78]
Giuffrida D, Dugo P, Dugo G, Torre G, Mondello L. Analysis of native carotenoid composition of sweet bell peppers by serially coupled C30 columns. Nat Prod Commun 2011; 6(12): 1934578X1100601.
[http://dx.doi.org/10.1177/1934578X1100601207] [PMID: 22312714]
[79]
Rodriguez-Uribe L, Guzman I, Rajapakse W, Richins RD, O’Connell MA. Carotenoid accumulation in orange-pigmented Capsicum annuum fruit, regulated at multiple levels. J Exp Bot 2012; 63(1): 517-26.
[http://dx.doi.org/10.1093/jxb/err302] [PMID: 21948863]
[80]
Tsuboi M, Etoh H, Kato K, et al. Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite. J Agric Food Chem 2011; 59(19): 10572-8.
[http://dx.doi.org/10.1021/jf203493k] [PMID: 21899264]
[81]
Rodríguez-Burruezo A, González-Mas MC, Nuez F. Carotenoid composition and vitamin A value in ají (Capsicum baccatum L.) and rocoto (C. pubescens R. & P.), 2 pepper species from the Andean region. J Food Sci 2010; 75(8): S446-53.
[http://dx.doi.org/10.1111/j.1750-3841.2010.01795.x] [PMID: 21535519]
[82]
de Azevedo-Meleiro CH, Rodriguez-Amaya DB. Qualitative and quantitative differences in the carotenoid composition of yellow and red peppers determined by HPLC-DAD-MS. J Sep Sci 2009; 32(21): 3652-8.
[http://dx.doi.org/10.1002/jssc.200900311] [PMID: 19813226]
[83]
Siddique MA, Grossmann J, Gruissem W, Baginsky S. Proteome analysis of bell pepper (Capsicum annuum L.) chromoplasts. Plant Cell Physiol 2006; 47(12): 1663-73.
[http://dx.doi.org/10.1093/pcp/pcl033] [PMID: 17098784]
[84]
Czeczuga-Semeniuk E, Wolczynski S. Identification of carotenoids in ovarian tissue in women. Oncol Rep 2005; 14(5): 1385-92.
[http://dx.doi.org/10.3892/or.14.5.1385] [PMID: 16211314]
[85]
Schweiggert U, Kammerer DR, Carle R, Schieber A. Characterization of carotenoids and carotenoid esters in red pepper pods (Capsicum annuum L.) by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom 2005; 19(18): 2617-28.
[http://dx.doi.org/10.1002/rcm.2104] [PMID: 16124038]
[86]
Baranski R, Baranska M, Schulz H. Changes in carotenoid content and distribution in living plant tissue can be observed and mapped in situ using NIR-FT-Raman spectroscopy. Planta 2005; 222(3): 448-57.
[http://dx.doi.org/10.1007/s00425-005-1566-9] [PMID: 16007452]
[87]
Pérez-Gálvez A, Rios JJ, Mínguez-Mosquera MI. Thermal degradation products formed from carotenoids during a heat-induced degradation process of paprika oleoresins (Capsicum annuum L.). J Agric Food Chem 2005; 53(12): 4820-6.
[http://dx.doi.org/10.1021/jf050119x] [PMID: 15941322]
[88]
Topuz A, Ozdemir F. Influences of gamma-irradiation and storage on the carotenoids of sun-dried and dehydrated paprika. J Agric Food Chem 2003; 51(17): 4972-7.
[http://dx.doi.org/10.1021/jf034177z] [PMID: 12903955]
[89]
Breithaupt DE, Weller P, Grashorn MA. Quantification of carotenoids in chicken plasma after feeding free or esterified lutein and capsanthin using high-performance liquid chromatography and liquid chromatography-mass spectrometry analysis. Poult Sci 2003; 82(3): 395-401.
[http://dx.doi.org/10.1093/ps/82.3.395] [PMID: 12705399]
[90]
Molnár P, Deli J, Tóth G, Häberli A, Pfander H, Bernhard K. (9Z)-capsanthin-5,6-epoxide, a new carotenoid from the fruits of Asparagus falcatus. J Nat Prod 2001; 64(9): 1254-5.
[http://dx.doi.org/10.1021/np0101447] [PMID: 11575972]
[91]
Maoka T, Fujiwara Y, Hashimoto K, Akimoto N. Capsanthone 3,6-epoxide, a new carotenoid from the fruits of the red paprika Capsicum annuum L. J Agric Food Chem 2001; 49(8): 3965-8.
[http://dx.doi.org/10.1021/jf010338s] [PMID: 11513696]
[92]
Deli J, Molnár P, Matus Z, Tóth G. Carotenoid composition in the fruits of red paprika (Capsicum annuum var. Lycopersiciforme rubrum) during ripening; biosynthesis of carotenoids in red paprika. J Agric Food Chem 2001; 49(3): 1517-23.
[http://dx.doi.org/10.1021/jf000958d] [PMID: 11312889]
[93]
Deli J, Matus Z, Tóth G. Carotenoid composition in the fruits of Asparagus officinalis. J Agric Food Chem 2000; 48(7): 2793-6.
[http://dx.doi.org/10.1021/jf991243h] [PMID: 11032480]
[94]
Jarén-Galán M, Nienaber U, Schwartz SJ. Paprika (Capsicum annuum) oleoresin extraction with supercritical carbon dioxide. J Agric Food Chem 1999; 47(9): 3558-64.
[http://dx.doi.org/10.1021/jf9900985] [PMID: 10552685]
[95]
Kim JS, Ahn J, Lee SJ, Moon B, Ha TY, Kim S. Phytochemicals and antioxidant activity of fruits and leaves of paprika (Capsicum Annuum L., var. special) cultivated in Korea. J Food Sci 2011; 76(2): C193-8.
[http://dx.doi.org/10.1111/j.1750-3841.2010.01891.x] [PMID: 21535734]
[96]
Cervantes-Paz B, Yahia EM, de Jesús Ornelas-Paz J, et al. Antioxidant activity and content of chlorophylls and carotenoids in raw and heat-processed Jalapeño peppers at intermediate stages of ripening. Food Chem 2014; 146: 188-96.
[http://dx.doi.org/10.1016/j.foodchem.2013.09.060] [PMID: 24176331]
[97]
Cervantes-Paz B, Yahia EM, Ornelas-Paz JJ, Gardea-Béjar AA, Ibarra-Junquera V, Pérez-Martínez JD. Effect of heat processing on the profile of pigments and antioxidant capacity of green and red jalapeño peppers. J Agric Food Chem 2012; 60(43): 10822-33.
[http://dx.doi.org/10.1021/jf303091u] [PMID: 23050605]
[98]
Guzman I, Hamby S, Romero J, Bosland PW, O’Connell MA. Variability of carotenoid biosynthesis in orange colored Capsicum spp. Plant Sci 2010; 179(1-2): 49-59.
[http://dx.doi.org/10.1016/j.plantsci.2010.04.014] [PMID: 20582146]
[99]
Weissenberg M, Schaeffler I, Menagem E, Barzilai M, Levy A. Isocratic non-aqueous reversed-phase high-performance liquid chromatographic separation of capsanthin and capsorubin in red peppers (Capsicum annuum L.), paprika and oleoresin. J Chromatogr A 1997; 757(1-2): 89-95.
[http://dx.doi.org/10.1016/S0021-9673(96)00665-6] [PMID: 9025261]
[100]
Jeknić Z, Morré JT, Jeknić S, Jevremović S, Subotić A, Chen THH. Cloning and functional characterization of a gene for capsanthin-capsorubin synthase from tiger lily (Lilium lancifolium Thunb. ‘Splendens’). Plant Cell Physiol 2012; 53(11): 1899-912.
[http://dx.doi.org/10.1093/pcp/pcs128] [PMID: 23008421]
[101]
Patel K, Kumar V, Patel DK. An update of therapeutic potential and bioanalytical aspects of steroidal glycoalkaloid (solanidine). J Coast Life Med 2017; 5(3): 134-40.
[http://dx.doi.org/10.12980/jclm.5.2017J6-256]
[102]
Kulczyński B, Gramza-Michałowska A, Kobus-Cisowska J, Kmiecik D. The role of carotenoids in the prevention and treatment of cardiovascular disease – Current state of knowledge. J Funct Foods 2017; 38: 45-65.
[http://dx.doi.org/10.1016/j.jff.2017.09.001]
[103]
Granado-Lorencio F, Blanco-Navarro I, Pérez-Sacristán B, Hernández-Álvarez E. Biomarkers of carotenoid bioavailability. Food Res Int 2017; 99(Pt 2): 902-16.
[http://dx.doi.org/10.1016/j.foodres.2017.03.036] [PMID: 28847427]

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