![conference banner](/images/conference-banner.jpeg)
Abstract
Introduction: A new, ecological, and stability-indicating method by HPLC was developed for the quantification of moxifloxacin in tablets. A C18 column at 33°C, purified water acidified with 0.2% phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin-1, injection volume of 5 µL, and detection at 290 nm was used.
Method: The method was linear (2-12 µgmL-1), selective, accurate (100.86%), precise (RSD<2%), and robust.
Result: The retention time for moxifloxacin in tablets was approximately 4.4 minutes.
Conclusion: To sum up, a method based on the principles of green analytical chemistry was successfully developed and validated for the quantification of moxifloxacin in tablets.
Keywords: HPLC, green analytical chemistry, method validation, tablets, fluoroquinolone, moxifloxacin.
[http://dx.doi.org/10.1590/S1517-83822012000400008] [PMID: 24031955]
[http://dx.doi.org/10.1080/10826076.2018.1437748]
[http://dx.doi.org/10.3390/ijerph16071196] [PMID: 30987126]
[http://dx.doi.org/10.1039/c1pp05259d] [PMID: 22186905]
[http://dx.doi.org/10.1016/j.jchromb.2020.122397] [PMID: 33091676]
[http://dx.doi.org/10.1007/s11094-018-1879-1]
[http://dx.doi.org/10.1016/j.jpba.2020.113137] [PMID: 32086125]
[http://dx.doi.org/10.1016/j.trac.2013.04.010]
[http://dx.doi.org/10.1016/j.jsps.2018.07.011] [PMID: 30627046]
[http://dx.doi.org/10.22456/2527-2616.89412]
[http://dx.doi.org/10.22456/2527-2616.89411]
[http://dx.doi.org/10.5935/sc.2019.009]
[http://dx.doi.org/10.1093/chromsci/bmab078] [PMID: 34131704]
[http://dx.doi.org/10.1021/acs.chemrev.7b00571] [PMID: 29300087]
[http://dx.doi.org/10.1016/j.trac.2019.03.016]
[http://dx.doi.org/10.22456/2527-2616.73755]
[http://dx.doi.org/10.2174/2213240607666200324140907]
[http://dx.doi.org/10.2174/1573412911666150519000155]
[http://dx.doi.org/10.1093/jaoac/63.6.1344] [PMID: 7451398]
![Wayfinder Image](/images/wayfinder.jpg)