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Current Green Chemistry

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ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

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Research Article

A New, Ecological and Stability-indicating Method by HPLC for the Quantification of Moxifloxacin in Tablets

Author(s): Thaisa Alves Celedonio da Silva, João Roberto da Silva Júnior and Ana Carolina Kogawa*

Volume 10, Issue 2, 2023

Published on: 03 May, 2023

Page: [165 - 173] Pages: 9

DOI: 10.2174/2213346110666230331085433

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Abstract

Introduction: A new, ecological, and stability-indicating method by HPLC was developed for the quantification of moxifloxacin in tablets. A C18 column at 33°C, purified water acidified with 0.2% phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin-1, injection volume of 5 µL, and detection at 290 nm was used.

Method: The method was linear (2-12 µgmL-1), selective, accurate (100.86%), precise (RSD<2%), and robust.

Result: The retention time for moxifloxacin in tablets was approximately 4.4 minutes.

Conclusion: To sum up, a method based on the principles of green analytical chemistry was successfully developed and validated for the quantification of moxifloxacin in tablets.

Keywords: HPLC, green analytical chemistry, method validation, tablets, fluoroquinolone, moxifloxacin.

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[1]
European Pharmacopoeia, 10th ed; Council of Europe: Strasbourg, 2019.
[2]
USP 42. The United States Pharmacopeia. , 42nd ed; The National Formulary (NF 37): Rockville, MD, United States Pharmacopeia Convention 2020.
[3]
Abdelaziz, A.A.; Elbanna, T.E.; Gamaleldeen, N.M. Validated microbiological and HPLC methods for the determination of moxifloxacin in pharmaceutical preparations and human plasma. Braz. J. Microbiol., 2012, 43(4), 1291-1301.
[http://dx.doi.org/10.1590/S1517-83822012000400008] [PMID: 24031955]
[4]
Momin, M.A.M.; Rangnekar, B.; Das, S.C. Development and validation of a RP-HPLC method for simultaneous quantification of bedaquiline (TMC207), moxifloxacin and pyrazinamide in a pharmaceutical powder formulation for inhalation. J. Liq. Chromatogr. Relat. Technol., 2018, 41(8), 415-421.
[http://dx.doi.org/10.1080/10826076.2018.1437748]
[5]
Attimarad, M.; Shahzad Chohan, M.; Ahmed Balgoname, A. Simultaneous determination of moxifloxacin and flavoxate by RP-HPLC and ecofriendly derivative spectrophotometry methods in formulations. Int. J. Environ. Res. Public Health, 2019, 16(7), 1196.
[http://dx.doi.org/10.3390/ijerph16071196] [PMID: 30987126]
[6]
Hubicka, U. Krzek, J.; Żuromska, B.; Walczak, M.; Żylewski, M.; Pawłowski, D. Determination of photostability and photodegradation products of moxifloxacin in the presence of metal ions in solutions and solid phase. Kinetics and identification of photoproducts. Photochem. Photobiol. Sci., 2012, 11(2), 351-357.
[http://dx.doi.org/10.1039/c1pp05259d] [PMID: 22186905]
[7]
Zheng, X.; Jongedijk, E.M.; Hu, Y.; Kuhlin, J.; Zheng, R.; Niward, K.; Paues, J.; Xu, B.; Davies Forsman, L.; Schön, T.; Bruchfeld, J.; Alffenaar, J.W.C. Development and validation of a simple LC-MS/MS method for simultaneous determination of moxifloxacin, levofloxacin, prothionamide, pyrazinamide and ethambutol in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2020, 1158, 122397.
[http://dx.doi.org/10.1016/j.jchromb.2020.122397] [PMID: 33091676]
[8]
Phani Sekhar Reddy, G.; Navyasree, K.S.; Jagadish, P.C.; Bhat, K. Analytical method development and validation for HPLC-ECD determination of moxifloxacin in marketed formulations. Pharm. Chem. J., 2018, 52(7), 674-679.
[http://dx.doi.org/10.1007/s11094-018-1879-1]
[9]
LLopis, B; Funck-Brentano, C.; Tissot, N.; Bleibtreu, A.; Jaureguiberry, S.; Fourniols, E.; Aubry, A.; Zahr, N.; Barrut, N.; Bonnet, I.; Calin, R.; Caumes, E.; Clarenc On, F.; Daas, G.; Fautrel, B.; Fustier, A.; Gandjbakhch, F.; Haddad, E.; Khiami, F.; Lazennec, J.; Marchant, M.; Mercy, G.; Metz, C.; Miu, M.; Mitrovic, S.; Monsel, G.; Monzani, Q.; Reubrecht, V.; Robert, J. Development and validation of a UPLC-MS/MS method for simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin in human plasma: Application to the therapeutic drug monitoring in osteoarticular infections. J. Pharm. Biomed. Anal., 2020, 183, 113137.
[http://dx.doi.org/10.1016/j.jpba.2020.113137] [PMID: 32086125]
[10]
Gałuszka, A.; Migaszewski, Z.; Namieśnik, J. The 12 principles of green analytical chemistry and the SIGNIFICANCE mnemonic of green analytical practices. Trends Analyt. Chem., 2013, 50, 78-84.
[http://dx.doi.org/10.1016/j.trac.2013.04.010]
[11]
de Marco, B.A.; Rechelo, B.S.; Tótoli, E.G.; Kogawa, A.C.; Salgado, H.R.N. Evolution of green chemistry and its multidimensional impacts: A review. Saudi Pharm. J., 2019, 27(1), 1-8.
[http://dx.doi.org/10.1016/j.jsps.2018.07.011] [PMID: 30627046]
[12]
Ghidini, L.; Kogawa, A.; Salgado, H.R.N. Eco-friendly green liquid chromatographic for determination of doxycycline in tablets and in the presence of its degradation products. Drug Analytic. Res., 2018, 2(2), 49-55.
[http://dx.doi.org/10.22456/2527-2616.89412]
[13]
Lima, J.; Kogawa, A.; Salgado, H.R.N. Green analytical method for quantification of secnidazole in tablets by HPLC-UV. Drug Analytic. Res., 2018, 2(2), 20-26.
[http://dx.doi.org/10.22456/2527-2616.89411]
[14]
Kogawa, A.C.; Peltonen, L.; Salgado, H.R.N.; Chorillis, M. Clean, safe and fast method by HPLC for quantification of rifaximin-based samples. Sci. Chromatogr., 2019, 11(3), 98-107.
[http://dx.doi.org/10.5935/sc.2019.009]
[15]
da Trindade, M.T.; Kogawa, A.C.; Salgado, H.R.N. A clean, sustainable and stability-indicating method for the quantification of ceftriaxone sodium in pharmaceutical product by HPLC. J. Chromatogr. Sci., 2022, 60(3), 260-266.
[http://dx.doi.org/10.1093/chromsci/bmab078] [PMID: 34131704]
[16]
Clarke, C.J.; Tu, W.C.; Levers, O.; Bröhl, A.; Hallett, J.P. Green and sustainable solvents in chemical processes. Chem. Rev., 2018, 118(2), 747-800.
[http://dx.doi.org/10.1021/acs.chemrev.7b00571] [PMID: 29300087]
[17]
Armenta, S.; Garrigues, S.; Esteve-Turrillas, F.A.; de la Guardia, M. Green extraction techniques in green analytical chemistry. Trends Analyt. Chem., 2019, 116, 248-253.
[http://dx.doi.org/10.1016/j.trac.2019.03.016]
[18]
Kogawa, A.C.; Salgado, H.R.N. Golden age of green chemistry. EC Microbiol., 2017, 12, 52-54.
[19]
Kogawa, A.C.; Salgado, H.R.N. Analytical methods: Where do we stand in the current environmental scenario? EC Microbiol., 2017, 13, 102-104.
[20]
Kogawa, A.C.; Salgado, H.R.N. Ethanol on HPLC: Epiphany or Nonsense? Acta Sci Pharm Sci, 2018, 2, 14-15.
[21]
Figueiredo, A.L.; Kogawa, A.C.; Salgado, H.R.N. Development and validation of an ecological, new and rapid stability-indicating High Performance Liquid Chromatographic method for quantitative determination of aztreonam in lyophilized powder for injection. Drug Analytic. Res., 2017, 1(1), 24-30.
[http://dx.doi.org/10.22456/2527-2616.73755]
[22]
Aleixa do Nascimento, P.; Kogawa, A.C.; Salgado, H.R.N. A new ecological HPLC method for determination of vancomycin dosage form. Curr. Chromatogr., 2020, 7(2), 82-90.
[http://dx.doi.org/10.2174/2213240607666200324140907]
[23]
FDA. Food and Drug Administration. Validation of Chromatographic Methods; Center for Drug and Evaluation and Research: Washington, 2004.
[24]
Kogawa, A.C.; Salgado, H.R.N. Impurities and Forced Degradation Studies: A Review. Curr. Pharm. Anal., 2015, 12, 18-24.
[http://dx.doi.org/10.2174/1573412911666150519000155]
[25]
AOAC – Association of Official Analytical Chemists. Official Methods of Analysis, 2002.
[26]
Horwitz, W.; Kamps, L.V.R.; Boyer, K.W. Quality assurance in the analysis of foods and trace constituents. J. Assoc. Off. Anal. Chem., 1980, 63(6), 1344-1354.
[http://dx.doi.org/10.1093/jaoac/63.6.1344] [PMID: 7451398]
[27]
Youden, W.J.; Steiner, E.H. Statistical manual of AOAC – Association of Official Analytical Chemistry; AOAC: Washington, 1975, p. 88.
[28]
ICH – International Conference on Harmonization of technical requirements for registration of pharmaceuticals for human use. In: Validation of analytical procedures: Text and Methodology Q2 (R1); ICH Steering Committee: Switzerland, 2005.

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