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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Mini-Review Article

Coumarin as a Privileged and Medicinally Important Scaffold in the Treatment of Tuberculosis

Author(s): Vaibhav Gupta, Ramesh Ambatwar, Neeru Bhanwala and Gopal L. Khatik*

Volume 23, Issue 16, 2023

Published on: 20 April, 2023

Page: [1489 - 1502] Pages: 14

DOI: 10.2174/1568026623666230330084058

Price: $65


Coumarin and its derivatives, which are abundant in nature, have a significant role in medicinal chemistry due to their ability to bind with different targets or receptors. In addition, these possess a wide range of biological activity. Thus coumarin-based scaffold has inspired even further research into coumarin and its substituted derivatives, allowing for the creation of a huge variety of structurally different substituted products. In recent, these were reported to have potent antitubercular activity. Tuberculosis (TB) is a serious deadly infectious bacterial disease caused by grampositive Mycobacterium tuberculosis. This review discusses various developments going on in the field of medicinal chemistry towards designing, synthesizing, and discovering coumarin-based antitubercular agents all across the globe.

Keywords: Coumarin, Natural product, Tuberculosis, Anti-tubercular, Mycobacterium tuberculosis, Bis-coumarin.

Graphical Abstract
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