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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Solvent-free Microwave-assisted Synthesis of 1-(1,3-diphenyl-1H-pyrazol- 4-yl)-3-(2-hydroxyphenyl) Propane-1,3-dione Using K2CO3 as Green Solid Support

Author(s): Namdeo T. Dhokale, Satish B. Kale, Sadashiv S. Nagre, Shankaraiah G. Konda and Navanath R. Dalvi*

Volume 20, Issue 9, 2023

Published on: 04 May, 2023

Page: [871 - 876] Pages: 6

DOI: 10.2174/1570178620666230329104520

Price: $65

Abstract

We herein present the synthesis of 1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(2-hydroxysubstituted phenyl) propane-1,3-dione using microwave irradiation. Reactions were carried out by employing a solvent-free path using K2CO3 as green solid support. The results were compared with those of the conventional method. This microwave-assisted synthesis avoids hazardous solvents and reduces the number of steps and time, providing increased yields. The synthesized products were characterized by IR, 1H NMR, and mass spectrometry.

Keywords: Synthesis, solvent-free, green solid, microwave irradiation, pyrazole, K2CO3.

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