Endoplasmic Reticulum as a Therapeutic Target in Cancer: Is there
a Role for Flavonoids?

Ava      Aghakhani; Mehrnoush   Baradaran   Hezave; Asma      Rasouli; Masoumeh      Saberi Rounkian; Fatemeh      Soleimanlou; Arian      Alhani; Nasim      Sabet Eqlidi; Maryam      Pirani; Saba      Mehrtabar; Nasibeh      Zerangian; Asiyeh      Pormehr-Yabandeh; Kimia      Keylani; Neda      Tizro; Niloofar      Deravi
doi:10.2174/1566524023666230320103429
Abstract

Flavonoids are classified into subclasses of polyphenols, a multipurpose category of natural compounds which comprises secondary metabolites extracted from vascular plants and are plentiful in the human diet. Although the details of flavonoid mechanisms are still not realized correctly, they are generally regarded as antimicrobial, anti-fungal, anti-inflammatory, anti-oxidative; anti-mutagenic; anti-neoplastic; anti-aging; anti-diabetic, cardio-protective, etc. The anti-cancer properties of flavonoids are evident in functions such as prevention of proliferation, metastasis, invasion, inflammation and activation of cell death. Tumors growth and enlargement expose cells to acidosis, hypoxia, and lack of nutrients which result in endoplasmic reticulum (ER) stress; it triggers the unfolded protein response (UPR), which reclaims homeostasis or activates autophagy. Steady stimulation of ER stress can switch autophagy to apoptosis. The connection between ER stress and cancer, in association with UPR, has been explained. The signals provided by UPR can activate or inhibit anti-apoptotic or apoptotic pathways depending on the period and grade of ER stress. In this review, we will peruse the link between flavonoids and their impact on the endoplasmic reticulum in association with cancer therapy.
Keywords: Flavonoid, endoplasmic reticulum, ER stress, cancer, malignancy, tumor.
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DOI https://dx.doi.org/10.2174/1566524023666230320103429	Print ISSN 1566-5240
Publisher Name Bentham Science Publisher	Online ISSN 1875-5666
Current Molecular Medicine

Endoplasmic Reticulum as a Therapeutic Target in Cancer: Is there a Role for Flavonoids?

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