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Current Drug Therapy

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ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

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Review Article

Saraca asoca: From Traditional Herb to Modern Drug as a Cure for Various Diseases

Author(s): Faiza Fathima, Rabea Parveen, Mohammad Aasif Khan, Zoya Malik, Saad Mustafa, Sheersh Massey, Sayeed Ahmad and Syed Akhtar Husain*

Volume 18, Issue 4, 2023

Published on: 18 April, 2023

Page: [285 - 297] Pages: 13

DOI: 10.2174/1574885518666230316111902

Price: $65

Abstract

Background: Saraca asoca (Ashoka, family; Caesalpiniaceae) is an indigenous sacred tree, native to India. It has been used in various traditional medicinal systems and is one such plant that is highly therapeutic but its use in disease management is underrated in today’s era and has lost its importance.

Objective: This narrative review is written to provide the information on medicinal importance of S. asoca and the significance of S. asoca in various traditional medicinal systems.

Methods: Different databases were searched to gather information. Research articles, abstracts, and reviews are included in this review.

Results: Saraca asoca is known for its unique pharmacological role in treating various uterine complications, menstrual disorders, and bacterial infections, bleeding hemorrhoids, urinary and dermatological problems. The stem bark of the tree is the principal constituent for treating menorrhagia and genito-urinary disorders. The stem bark, leaves, and seeds of S. asoca are known to contain flavonoids, tannins, alkaloids, glycosides, polyphenolics, fatty acids, and saponins. The reported major phytoconstituents responsible for its therapeutic uses are epicatechin, procyanidin B2, lyoniside, nudiposide, catechin, leucocyanidin, and leucopelargonidin. Various pharmacological activities of this plant are discussed in this review.

Conclusion: It has been proved that Saraca asoca possesses several pharmacological properties and is useful in treating various diseases. More studies on quality control, standardization, and clinical trials on S. asoca should be performed, so that this plant could be utilized as an effective anti-cancer drug which could be a promising source for the herbal and pharmaceutical industry.

Keywords: Saraca asoca, traditional medicine, phytoconstituents, pharmacological uses, phytochemistry, anti-cancer activity.

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[1]
Saha J, Mukherjee S, Gupta K, Gupta B. High-performance thin-layer chromatographic analysis of antioxidants present in different parts of Saraca asoca (Roxb.) de Wilde. J Pharm Res 2013; 7(9): 798-803.
[http://dx.doi.org/10.1016/j.jopr.2013.10.004]
[2]
Madhushree SI, Raviraja Shetty G, Souravi K, Rajasekharan PE, Ganapathi M, Ravi CS. Standardization of seed and vegetative propagation techniques in saraca asoca (roxb.) de wilde: An endangered medicinal plant. Int J Curr Microbiol Appl Sci 2018; 7(4): 1327-35.
[http://dx.doi.org/10.20546/ijcmas.2018.704.148]
[3]
HKI P. Pradeep APC, Devinda KDU, Ratnayake R GD. Tyrosinase inhibitory effects of saraca asoca bark, leaf and seed. J Complement Med Alt Healthc 2017; 4(3): 1-3.
[4]
Sarda N, Prasad SE, Mitra SK. Evaluation of efficacy and safety in menorrhagia. Med Updat 2007; 15(5): 26-32.
[5]
Mokat DN. Growth performance and flowering in planted saplings of Saraca asoca (ROXB.). Life Sci Leafl 2014; 56: 9.
[6]
Suja M, Rajan S, Thirunalasundari T, Jana B, Thenmozhi S. Pharmacognostical and phytochemical studies of an ayurvedic drug Saraca asoca stem bark. J Pharm Res 2012; 5(2): 1119-21.
[7]
Bisht A, Irshad S, Rawat AKS, Dwivedi H. Pharmacognostical studies on Saraca asoca (Roxb.) Willd. flower. Trop Plant Res 2017; 4(1): 153-60.
[http://dx.doi.org/10.22271/tpr.2017.v4.i1.022]
[8]
Athiralakshmy TR, Divyamol AS, Nisha P. Phytochemical screening of Saraca asoca and antimicrobial activity against bacterial species. Asian J Plant Sci Res 2016; 6(2): 30-6.
[9]
Mohan C, Kistamma S, Vani PNR. Biological activities of different parts of Saraca asoca an endangered valuable medicinal plant. Int J Curr Microbiol Appl Sci 2016; 5(3): 300-8.
[10]
Bhalerao SA, Verma DR, Didwana VS, Teli NC. Wild: An overview. Ann plant Sci 2014; 3(7): 770-5.
[11]
Patwardhan A, Pimputkar M, Mhaskar M, et al. Distribution and population status of threatened medicinal tree Saraca asoca (Roxb.) De Wilde from Sahyadri–Konkan ecological corridor. Curr Sci 2016; 111(9): 1500-6.
[http://dx.doi.org/10.18520/cs/v111/i9/1500-1506]
[12]
Suja A. Medicinal plants of Western Ghats. Sahyadri E News 2005; 12: 2-16.
[13]
Sumangala RC, Shaanker RU, Dayanandan S, Vasudeva R, Ravikanth G. Identification of novel microsatellite markers for Saraca asoca, a medicinally important tree species in India. J Genet 2016; 93(S2): 93-5.
[http://dx.doi.org/10.1007/s12041-013-0277-4]
[14]
Prajapati B, Savai J, Pandita N. Method development and validation for simultaneous estimation of quercetin and rutin in bark of Saraca asoca and herbal formulation by HPTLC. Indo Am J Pharm Res 2013; 3: 3233-45.
[15]
Pradhan P, Joseph L, George M, Kaushik N, Chulet R. Pharmacognostic, phytochemical and quantitative investigation of Saraca asoca leaves. J Pharm Res 2010; 3(4): 776-80.
[16]
Borokar AA, Pansare TA. Plant profile, phytochemistry and pharmacology of Ashoka (Saraca asoca (Roxb.), De. Wilde)-A comprehensive review. Int J Ayurvedic Herb Med 2017; 7(2): 2524-41.
[17]
Debnath M, Karan TK, Pandey JN, Biswas M. Comparative Phytochemical and biological evaluation of different extracts obtained from the leaves of Saraca asoka. Pharmacogn J 2010; 2(12): 476-80.
[http://dx.doi.org/10.1016/S0975-3575(10)80034-3]
[18]
Kauser AS, Hasan A, Parrey SA, Ahmad W. Ethnobotanical, phytochemical and pharmacological properties of Saraca asoca bark: A Review. Eur J Pharm Med Res 2016; 3(6): 274-9.
[19]
Mishra SB, Vijayakumar M. Floral morphology and HPTLC fingerprint profile of Saraca asoca (Roxb) De Wilde (Caesalpiniaceae): A consecrated tree of India. Int Lett Nat Sci 2015; p. 43.
[20]
Deepa KS, Santoshkumar AV, Rekha K, Joseph J. Karyotype analysis in Saraca asoca (Roxb.) de Wilde. J Trop Agric 2013; 51(1): 135-9.
[21]
Singh S, Anantha Krishna TH, Kamalraj S, Kuriakose GC, Valayil JM, Jayabaskaran C. Phytomedicinal importance of Saraca asoca (Ashoka): an exciting past, an emerging present and a promising future. Curr Sci 2015; 109(10): 1790-801.
[http://dx.doi.org/10.18520/cs/v109/i10/1790-1801]
[22]
Manohar VR, Chandrashekar R, Rao SN. Phytochemical analysis of Saraca asoca bark extracts. Int J Pharm Sci Rev Res 2012; 17: 101-3.
[23]
Smitha GR, Thondaiman V. Reproductive biology and breeding system of Saraca asoca (Roxb.) De Wilde: A vulnerable medicinal plant. Springerplus 2016; 5(1): 2025.
[http://dx.doi.org/10.1186/s40064-016-3709-9] [PMID: 27995002]
[24]
Prachi S, Pramod K. Evaluation on the seed germination rate of Ashoka (Saraca asoca (Roxb.) De Wilde) with special reference to Vrikshayurveda. Int J Ayurveda Pharma Res 2016; 4(10): 1-4.
[25]
Prajith TM, Chandran A. Multiple shoots and roots of germinating Saraca asoca seeds. Int J Plant, Anim. Environ Sci 2015; 5(1): 272-7.
[26]
Bhattacharya R, Reddy KRC, Mishra AK. Export strategy of Ayurvedic products from India. Int J Ayurvedic Med 2014; 5(1): 125-8.
[27]
Pai SR, Roy S, Hegde S, Hegde HV, Jalalpure SS, Peram MR. Resolving identification issues of Saraca asoca from its adulterant and commercial samples using phytochemical markers. Pharmacogn Mag 2017; 13(50): 266.
[http://dx.doi.org/10.4103/pm.pm_417_16] [PMID: 28808391]
[28]
Tiwari S. Plants: A rich source of herbal medicine. J Nat Prod 2008; 1(0): 27-35.
[29]
Marimuthu P, Rekha P, Kalidass C, Mohan VR. Pharmaco-chemical characterisation of three ethnomedicinal plants Indian J Bot Res 973: 2233
[30]
Arya V. Ayurveda: From traditional use to scientific research. Int J Curr Res Acad Rev 2013; 1(1): 45-56.
[31]
Mirgal AB, Gunaga RP, Salunkhe CB. Seed size and its influence on germination, seedling growth and biomass in Saraca asoca (Roxb). De Wilde, critically endangered tree species of Western ghats, India. J Appl Nat Sci 2016; 8(3): 1599-602.
[http://dx.doi.org/10.31018/jans.v8i3.1007]
[32]
Gahlaut A, Gothwal A, Hooda V, Dabur R. RAPD patterns of some important medicinal plants and their substitutes used in Ayurveda to identify the genetic variations. Int J Pharm Pharm Sci 2013; 5(1): 239-41.
[33]
Sekar S, Mariappan S. Traditionally fermented biomedicines, arishtas and asavas from Ayurveda. 2008. Available from: https://www.semanticscholar.org/paper/Traditio-nally-fermented-biomedicines%2C-arishtas-and-Sekar-Mariappan/a1ae5e22d5f538ec431cb299c98b56c853762485
[34]
Akhtar Y, Alamgir M, Khan MTH, Hannan J, Choudhuri MSK. A single blind randomised placebo controlled clinical trial of a classical Ayurvedic formulation Ashokarista in the treatment of menorrhagia and dysmenorrhoea. Orient Pharm Exp Med 2007; 7(4): 372-8.
[http://dx.doi.org/10.3742/OPEM.2007.7.4.372]
[35]
Rout S, Khare NBS. Vegetative propagation of Ashoka (Saraca asoca Roxb. De Wilde.) By stem cuttings. Pharma Innov J 2018; 7(1): 486-8.
[36]
Mohan C, Kumar SM, Naresh B, et al. Phytochemical studies of the endangered tree, Saraca asoca (Roxb.) De Wilde. Ann Phytomed 2017; VI(I): 76-82.
[http://dx.doi.org/10.21276/ap.2017.6.1.11]
[37]
Shukla AK. Study of Ashoka (Saraca asoca) Bark wsr to its samples available in the crude drug market of Bombay. J Ayurveda Integr Med Sci 2017; 2(04): 68-79.
[38]
Gupta M, Sasmal SMA. An experimental study to evaluate the analgesic, anti-inflammatory and antipyretic activities (Vednasthapan Karma) of the aqueous extract of Saraca asoca seeds. Int J Pharm Sci Rev Res 2014; 24(2): 188-94.
[39]
Thapliyal ACS. Nitrate reductase activity in the leaves of saraca asoca (roxb.), De. WILDE. Biotechnol Int 2012; 5(4): 129-41.
[40]
Biswas TK, Debnath PK. Aśoka (Saraca Indica Linn)-a cultural and scientific evaluation Indian J Hist Sci 1972; 7(2): 99-114.
[PMID: 11619603]
[41]
Gahlaut A, Taneja P, Shirolkar A, Nale A, Hooda V, Dabur R. Principal component and partial least square discriminant based analysis of methanol extracts of bark and regenerated bark of Saraca asoca. Int J Pharm Pharm Sci 2012; 4: 331-5.
[42]
Rajeshkumar PP, Hosagoudar VB, Anil K, Prajith TM. Endomycorrhizal association of Saraca asoca Roxb. WJ de Wilde. Bull Basic Appl Plant Biol 2012; 2(1): 1-6.
[43]
Beena C, Radhakrishnan VV. Quality assessment evaluation of the market samples of important ayurvedic drug asoka bark. Ann Phytomed 2012; 1(1): 95-8.
[44]
Hegde S, Pai SR, Roy S. Combination of DNA isolation and RPHPLC analysis method for bark samples of Saraca asoca and its adulterant. 3 Biotech 2017; 7(3): 1-9.
[45]
Mathew S, Mathew G, Joy PP, Skari BP, Joseph TS. Differentiation of saraca asoca crude drug from its adulterant. Anc Sci Life 2005; 24(4): 174-8.
[PMID: 22557174]
[46]
Shubhashree MN, Shantha TR, Ramarao V. REDDY MP, Venkateshwaraul G. A review on therapeutic uses of flowers as depicted in classical texts of Ayurveda and Siddha. J Res Educ Indian Med 2015; 21: 1-14.
[47]
Mishra AK, Gupta A, Gupta V, Sannd R, Bansal P. Asava and aristha: An ayurvedic medicine–An overview. Int J Pharm Biol Arch 2010; 1(1): 24-30.
[48]
Shruthi G, Joyappa MP, Chandrashekhar S, et al. Bactericidal property of Clerodendrum paniculatum and Saraca asoka against multidrug resistant bacteria, restoring the faith in herbal medicine. Int J Pharm Sci Res 2017; 8(9): 3863-71.
[49]
Dhiman K. Leucorrhoea in ayurvedic literature-a review. Ayurpharm Int J Ayur Alli Sci 2014; 3(3): 73-8.
[50]
Gautam P, Bairwa O, Dwivedi D, Kumar S, Singh AK. A progressive step towards classical uses of medicinal plants in gynecological disorders. JAIMS 2017; 2(3): 225-36.
[http://dx.doi.org/10.21760/jaims.v2i3.8235]
[51]
Mukhopadhyay MK, Banerjee P, Nath D. Phytochemicals–biomolecules for prevention and treatment of human diseases-a review. IJSER 2012; 3(7): 1-32.
[52]
Krishna MC, Sivaram G, Kumar PD, et al. Appraisal on ayurvedic herbs in the management of sthaulya (Obesity). Int J Ayurvedic Med 2017; 8(4): 159-68.
[53]
Urumarudappa SKJ, Gogna N, Newmaster SG, et al. DNA barcoding and NMR spectroscopy-based assessment of species adulteration in the raw herbal trade of Saraca asoca (Roxb.) Willd, an important medicinal plant. Int J Legal Med 2016; 130(6): 1457-70.
[http://dx.doi.org/10.1007/s00414-016-1436-y] [PMID: 27627901]
[54]
Das M, Jain V, Malhotra S. Impact of climate change on medicinal and aromatic plants. Indian J Agric Sci 2016; 86(11): 1375-82.
[55]
CT S. CK J, KM P. Identification of validated substitute for Asoka (Saraca asoca (Roxb.) Willd.) by phytochemical and pharmacological evaluations. Futur J Pharm Sci 2020; 6(1): 1-11.
[56]
BB W. Sarda PD. Antimicrobial efficacy of Saraca asoca in comparison with commercial antibiotics. J Med Chem Drug Discov 2017; 3(2): 147-52.
[57]
Cibin TR, Devi DG, Abraham A. Chemoprevention of two-stage skin cancer in vivo by Saraca asoca. Integr Cancer Ther 2012; 11(3): 279-86.
[http://dx.doi.org/10.1177/1534735411413264] [PMID: 21771821]
[58]
Duttagupta DS, Jadhav VM, Kadam VJ. Simultaneous estimation of glycyrrhizin and Catechin from marketed herbal formulations by HPTLC. World J Pharm Pharm Sci 2016; 1098-110.
[59]
Kumar N, Cheruku SP, Chamallamudi MR, et al. Neuroprotective potential of methanolic extract of Saraca asoca bark against doxorubicin-induced neurotoxicity. Pharmacogn Mag 2019; 15(61): 309.
[http://dx.doi.org/10.4103/pm.pm_79_18]
[60]
Bartariya G, Kumar A, Kumar B. Qualitative and quantitative estimation of total phenolics and total flavonoids in leaves extract of Saraca asoca (Roxb.). Indo Am J Pharm Sci 2017; 4(11): 3863-8.
[61]
Pandey AK, Ojha V, Yadav S, Sahu SK. Phytochemical evaluation and radical scavenging activity of Bauhinia variegata, Saraca asoka and Terminalia arjuna Barks. Res J Phytochem 2011; 5(2): 89-97.
[http://dx.doi.org/10.3923/rjphyto.2011.89.97]
[62]
Singh D, Yadav P, Nayak S, Hatwar B. Antiacne, preliminary phytochemical and physicochemical investigation of Saraca asoca bark. J Nat Prod Plant Resour 2012; 2: 119-26.
[63]
Sasmal S, Majumdar S, Gupta M, Mukherjee A, Mukherjee PK. Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb. Asian Pac J Trop Biomed 2012; 2(10): 782-6.
[http://dx.doi.org/10.1016/S2221-1691(12)60229-9] [PMID: 23569847]
[64]
Patil AM, Potdar GG, Pawar SGPS. Preliminary phytochemical screening of some important medicinal plants. Indian J Appl Res 2018; 8(4): 28-30.
[http://dx.doi.org/10.36106/IJAR]
[65]
Pradhan P, Joseph L, Gupta V, et al. Saraca asoca (Ashoka): A review. J Chem Pharm Res 2009; 1(1): 62-71.
[66]
Khatoon S, Singh N, Kumar S, Srivastava N, Rathi A, Mehrotra S. Authentication and quality evaluation of an important Ayurvedic drug-Ashoka bark. J Sci Ind Res 2009; 68(5): 393-400.
[67]
Sadhu SK, Khatun A, Phattanawasin P, Ohtsuki T, Ishibashi M. Lignan glycosides and flavonoids from Saraca asoca with antioxidant activity. J Nat Med 2007; 61(4): 480-2.
[http://dx.doi.org/10.1007/s11418-007-0182-3]
[68]
Panchawat S, Sisodia SS. In-vivo antidiarrhoeal activity of extracts from stem bark of Saraca asoca Roxb. prepared by different extraction methods. Indent 2011; 166(113548)
[69]
Naidu LM. Evaluation of antimicrobial activity and phytochemical constituents of Saraca asoca stem bark. Open Access J J Med Aromat Plants 2016; 7(1): 9.
[70]
Ahmad F, Misra L, Tewari R, Gupta P, Gupta VK, Darokar MP. Isolation and HPLC profiling of chemical constituents of Saraca asoca stem bark. Indian J Chem Sect 2016; 55(3): 353-61.
[71]
Saha J, Mitra T, Gupta K, Mukherjee S. Phytoconstituents and HPTLC analysis in Saraca asoca (Roxb.) Wilde. Int J Pharm Pharm Sci 2012; 4(1): 96-9.
[72]
Ahmad F, Misra L, Gupta VK, et al. Synergistic effect of (+)-pinitol from Saraca asoca with β-lactam antibiotics and studies on the in silico possible mechanism. J Asian Nat Prod Res 2016; 18(2): 172-83.
[http://dx.doi.org/10.1080/10286020.2015.1075005] [PMID: 26527419]
[73]
Mukhopadhyay MK, Nath D. Phytochemical screening and toxicity study of Saraca asoca bark methanolic extract. Int J Phytomed 2011; 3(4): 498.
[74]
Fatema S, Farooqui M, Ubale M, Mohd Arif P. Physicochemical, phytochemical, biological and chromatographic evaluation of Saraca asoca plant leaves. Rasayan J Chem 2019; 12(2): 616-24.
[http://dx.doi.org/10.31788/RJC.2019.1222065]
[75]
Tom KM, Benny PJ. A Review of phytopharmacological studies on some common flowers. Int J Curr Pharm 2016; 7(3): 171-80.
[76]
Mittal A, Kadyan P, Gahlaut A, Dabur R. Nontargeted identification of the phenolic and other compounds of Saraca asoca by high performance liquid chromatography-positive electrospray ionization and quadrupole time-of-flight mass spectrometry. Int Sch Res Not 2013.
[http://dx.doi.org/10.1155/2013/293935]
[77]
Dharamdasani L, Pathan S, Bodhankar P, Rai K, Nair P. Synthesis of silver nanoparticle from saraca asoca leaf extract & study of its antibacterial and antioxidant activity. Int J Health Sci Res 2017; 7(8): 342-50.
[78]
Maurya IC. Neetu, Gupta AK, Srivastava P, Bahadur L. Natural dye extracted from Saraca asoca flowers as sensitizer for TiO2-based dye-sensitized solar cell. J Sol Energy Eng 2016; 138(5): 051006.
[http://dx.doi.org/10.1115/1.4034028]
[79]
Panchawat S, Sisodia SS. In vitro antioxidant activity of Saraca asoca Roxb. De Wilde stem bark extracts from various extraction processes. Asian J Pharm Clin Res 2010; 3(3): 231-3.
[80]
Gupta M, Sasmal S, Mukherjee A. Therapeutic effects of acetone extract of saraca asoca seeds on rats with adjuvant-induced arthritis via attenuating inflammatory responses. Int Sch Res Not 2014.
[http://dx.doi.org/10.1155/2014/959687]
[81]
Jain A, Jasmine SS, Saini V. Hypolipidemic, hypoglycemic and antioxidant potential of Saraca asoca ethanolic leaves extract in streptozotocin induced-experimental diabetes. Int J Pharm Pharm Sci 2013; 5(1): 302-5.
[82]
Dabur R, Gahlaut A, Hooda V, Shirolkar A. β-sitosterol in different parts of Saraca asoca and herbal drug ashokarista: Qualiquantitative analysis by liquid chromatography-mass spectrometry. J Adv Pharm Technol Res 2013; 4(3): 146-50.
[http://dx.doi.org/10.4103/2231-4040.116783] [PMID: 24083202]
[83]
Salvi S, Varghese R, Digholkar G, et al. Saraca asoca: A scoping review on the phytoconstituents, bioactives and their therapeutic effects. German J Pharmaceut Biomater 2022; 1(3): 3-13.
[http://dx.doi.org/10.5530/gjpb.2022.3.11]
[84]
Middelkoop TB, Labadie RP. The action of Saraca asoca Roxb. de Wilde bark on the PGH2 synthetase enzyme complex of the sheep vesicular gland. Z Naturforsch C J Biosci 1985; 40(7-8): 523-6.
[http://dx.doi.org/10.1515/znc-1985-7-812] [PMID: 3931371]
[85]
Sulakshan CS, Gamit RV, Ashok BK, Shukla VJ, Das P, Ravishankar B. A comparative acute toxicity evaluation of ashoka ksheerapaka prepared from two different species of saraca (S. asoca & S. thaipingensis). Glob J Res Med Plants Indig Med 2013; 2(4): 270.
[86]
Rajith NP, Ambily DV, Dan VM, Devi PS, George V, Pushpangadan P. A survey on ethnomedicinal plants used for menstrual disorders in Kerala. Indian J Tradit Knowl 2012; 11(3): 453-60.
[87]
Mohan C, Reddy MS, Naresh B, et al. RAPD studies of Saraca asoca by fluorescent-labeled primers and development of micropropagation protocol for its conservation. Int J Appl Agric Res 2017; 12(2): 137-51.
[88]
Yadav JP, Kumar S SP. Folk medicine used in gynecological ad other related problems by rural population of Haryana Indian J tradiitonal Knowl 2006; 5(6): 323-6.
[89]
Rama S. Conservation and cultivation of threatened and high valued medicinal plants in North East India. Int J Biodivers Conserv 2013; 5(9): 584-91.
[90]
Shirin F, Parihar NS, Shah SN. Effect of nutrient media and KNO3 on in vitro plant regeneration in Saraca asoca (Roxb.) Willd. Am J Plant Sci 2015; 6(19): 3282-92.
[http://dx.doi.org/10.4236/ajps.2015.619320]
[91]
Nasrin D, Moushumi SJ, Ahmed R, et al. An evaluation of administration in diet of Saraca asoca (Roxb.) De Wilde bark extract on serum lipid profiles in rats. Adv Nat Appl Sci 2010; 4(3): 382-4.
[92]
Mishra D, Singh RK, Srivastava RK, Dubey SR. Ethnomedicinal plants used to cure the gynaecological disorders by ethnic populace of Sitapur district, Uttar Pradesh, India. Med Plant 2013; 5(4): 238-45.
[http://dx.doi.org/10.5958/j.0975-6892.5.4.038]
[93]
Sahoo H, Mahalik G. Ethnobotanical survey of medicinal plants of Kantapada block of Cuttack district, Odisha, India. Int J Biosci 2020; 16(5): 284-92.
[94]
Lalfakzuala R, Lalramnghinglova H KH. Ethnobotanical usages of plants in western Mizoram Indian J tradiitonal Knowl 2007; 6(3): 486-93.
[95]
Nutan C, Anupama S, Ziyaurrahman AR. Preclinical safety evaluation of aqueous bark extract of Saraca asoca Roxb: acute and subacute oral toxicity. Int J Pharm Res 2015; 5: 332-7.
[96]
Rajkumar MH, Sringeswara AN, Rajanna MD. Ex-situ conservation of medicinal plants at university of agricultural sciences, Bangalore, Karnataka. Recent Res Sci Technol. 2011; 3: 4.
[97]
Das B, Talukdar AD, Choudhury MD. A few traditional medicinal plants used as antifertility agents by ethnic people of Tripura, India. Int J Pharm Pharm Sci 2014; 6(3): 47-53.
[98]
Symun N, Bushra F, Tuli D, et al. Ayurvedic influences in folk medicine: a case study of a folk medicinal practitioner of Jhalokathi in Barisal district, Bangladesh. Am J Sustain Agric 2013; 7(4): 333-43.
[99]
Chakraborty A, Kosariya SSCM. A Review of Ethnomedicinal Practices for Gynaecological Disorders among the Various Tribes of Chhattisgarh. IOSR J Environ Sci Toxicol Food Technol 2015; 1(2): 55-62.
[100]
Punjaji SA, Reddy PG. Novus International Journal of Biotechnology & Bioscience
[101]
Prakash S, Ashoka KND. (Saraca indica linn.): A Persuasive Herb for menorrhagia. Int J Appl Ayurved Res 2015; 2: 92-7.
[102]
Ghildiyal JC, Juyal P, Sadana G. Indigenous uses of plants in different women ailments in Garhwal region. Indian J Pharmaceut Biol Res 2014; 2(1): 39-44.
[http://dx.doi.org/10.30750/ijpbr.2.1.6]
[103]
Pattanayak S, Maity D, Mitra S, Debnath PK, Mandal TK, Bandyopadhyay SK. Use of fresh parts of medicinal plants for health and production in livestock–a new concept of farming. Explor Anim Med Res 2013; 3(1): 7-16.
[104]
Deka A, Kalita JC, Singh YR, Deka M. Determination of estrogenicity of Asoca plant (Saraca asoca Linn.) in adult female ovariectomized mice. Int J Recent Sci Res 2012; 6: 7661-4.
[105]
Mitra SK, Gopumadhavan S, Venkataranganna MV, Sharma DNK. Anturlikar. Uterine tonic activity of U-3107, a herbal preparation in rats. Indian J Pharmacol 1999; 31(3): 200-3.
[106]
Bhandary MJ, Chandrashekar KR, Kaveriappa KM. Medical ethnobotany of the siddis of Uttara Kannada district, Karnataka, India. J Ethnopharmacol 1995; 47(3): 149-58.
[http://dx.doi.org/10.1016/0378-8741(95)01274-H] [PMID: 8569239]
[107]
Lall WS, Charan AA, Bind A. Antimicrobial activity of methanolic and acetonic extracts of Azadirachta indica, Saraca asoca and Curcuma longa. Int J Med Pharm Sci 2013; 3(2): 79-86.
[108]
Patni B, Chandra H. Identification of phytochemical contents and antimicrobial activity of Saraca asoca leaves extract. Environ Conserv J 2016; 17(3): 19-24.
[http://dx.doi.org/10.36953/ECJ.2016.17303]
[109]
Gahlaut A, Chhillar AK. Evaluation of antibacterial potential of plant extracts using resazurin based microtiter dilution assay. Int J Pharm Pharm Sci 2013; 5(2): 372-6.
[110]
Sujatha S, Prakash G. Bioactive screening and antimicrobial activity of flowers from the selected three medicinal plants on chosen microbes. Int J Curr Microbiol Appl Sci 2013; 2(5): 211-21.
[111]
Goutam KD, Sunil KS, Gyana RR. Effect of auxins on adventitious root development from nodal cuttings of Saraca asoka (Roxb.) de Wilde and associated biochemical changes. J Hortic For 2011; 3(10): 320-6.
[112]
Paranthaman M, Kumari RU, Narayanan NL, Sivasubramaniam K. Morphological characterization and in vitro callus induction in ashoka [Saraca asoca (Roxb.) de wilde.-A vulnerable medicinal tree. J Tree Sci 2017; 36(1): 103.
[http://dx.doi.org/10.5958/2455-7129.2017.00014.0]
[113]
Divya KR, Anjali AR, Kumar R. Phytochemical screening of Saraca asoca (Roxb.), De. Wild. J Pharmacogn Phytochem 2017; 6(3): 518-21.
[114]
Sarda P. Dr. Prsashar, K., Dr. Gupta, S., Dr. Damle, A., Dr. Gaikwad, A., & Warkhande B. An in-vitro study of the antimicrobial effect of Saraca asoca leaf extract on methicillin sensitive and methicillim resistant Staphylococcus aureus in combination with methicillin. Int J Curr Res 2017; 9(5): 49771-5.
[115]
Dabur R, Gupta A, Mandal TK, et al. Antimicrobial activity of some Indian medicinal plants. Afr J Tradit Complement Altern Med 2008; 4(3): 313-8.
[http://dx.doi.org/10.4314/ajtcam.v4i3.31225] [PMID: 20161895]
[116]
Deepti B, Santh Rani T, Srinivasa BP. Evaluation of anti-helmintic and wound healing potential of Saraca asoca (Roxb) bark. Pharmacogn J 2012; 4(33): 40-5.
[http://dx.doi.org/10.5530/pj.2012.33.7]
[117]
Gomathy S, Rathinam KM. Identification of Insecticidal compounds in Saraca asoca bark extract using gas chromatography and mass spectroscopic technique Asian J Innov Res 1(4): 23-8.
[118]
Xavier FG, Ratchagar JV, Seetharaman S, Sivasubramanian S, Somasundaram L. Role of Herbs in the Treatment of Rheumatoid Arthritis
[119]
Kaur A, Nain P, Nain J. Herbal plants used in treatment of rheumatoid arthritis: a review. Int J Pharm Pharm Sci 2012; 4(4): 44-57.
[120]
Thilagam E, Chidambaram K, Raviteja C, Vahana T, Vasudevan P, Garrido G. Anti-hyperglycemic and hypolipidemic effects of Saraca asoca (Roxb.) Wild. flowers in alloxan-treated diabetic rats. J Pharm Pharmacogn Res 2021; 9(1): 58-68.
[http://dx.doi.org/10.56499/jppres20.894_9.1.58]
[121]
Susila R, Gladys RJ, Arunadevi R, Jothi J, Arunachalam C, Balagurusamy K. A review on anti-diabetic herbs of Siddha system with special reference to it’s organoleptic quality (taste) as per tridosam concept. Int J Herb Med 2017; 5(5): 97-101.
[122]
Kumar A, Kumar B, Bartariya G. Evaluation of alpha-amylase inhibition assay in various foliar extract of Saraca asoca (ROXB.). Indo Am J Pharm Sci 2018; 5(1): 119-23.
[123]
Prathapan A, Nampoothiri SV, Mini S, Raghu KG. Antioxidant, antiglycation and inhibitory potential of Saraca ashoka flowers against the enzymes linked to type 2 diabetes and LDL oxidation. Eur Rev Med Pharmacol Sci 2012; 16(1): 57-65.
[PMID: 22338549]
[124]
Mishra SB, Vijayakumar M. Anti-hyperglycemic and antioxidant effect of Saraca asoca (Roxb. De Wilde) flowers in Streptozotocin-Nicotinamide induced diabetic rats: A therapeutic study. J Bioanal Biomed S 2014; 12: 2.
[125]
Sathya J, Shoba FG. valuation of antidiabetic effect of citrullus lanatus (thunb) seeds and Saraca asoca (roxb.) De. Wild. Flowers in streptozotocin-induced diabetic rats. 2017.
[126]
Banerjee A, De B. Antioxidant activity of ethnomedicinally used flowers of West Bengal, India. Int J Pharmacogn Phytochem Res 2014; 6(3): 622-35.
[127]
Kingston C, Jeeva S, Jeeva GM, Kiruba S, Mishra BP, Kannan D. Indigenous knowledge of using medicinal plants in treating skin diseases in Kanyakumari district, Southern India. Indian J Tradit Knowl 2009; 8(2): 196-200.
[128]
Jeeva GM, Jeeva S, Kingston C. Traditional treatment of skin diseases in South Travancore, southern peninsular India. Indian J Tradit Knowl 2007; 6(3): 498-501.
[129]
Manohar VR, Mohandas R, Chandrashekar R. Acute anxiolytic effect of ethanolic extract of Saraca asoca bark in wistar albino rats. Int J Bioassays 2013; 2(6): 926-8.
[130]
Manohar VR, Chandrashekar R, Rashmi Chandrashekar MR. Chronic anxiolytic activity of ethanolic extract of Saraca asoca bark in wistar albinorats. J Sci Innov Res 2014; 3(2): 173-6.
[http://dx.doi.org/10.31254/jsir.2014.3211]
[131]
Mishra NS, Prakash R, Mishra RC. Phytomedicinal uses of saponin containing herbs. Int J Chem Stud 2017; 1: 12-6.
[132]
Ahmed S, Hasan MM, Mahmood ZA. Antiurolithiatic plants of family Fabaceae: A memoir of mechanism of action, therapeutic spectrum, formulations with doses. J Pharmacogn Phytochem 2017; 6(3): 592-6.
[133]
Pradhan P, Joseph L, George M, Chulet R. Evaluation of the analgesic and antipyretic actions of the saraca asoca leaves in experimental animal models. Pharmacologyonline 2010; 1: 268-74.
[134]
Ghatak A, Nair S, Vajpayee A, et al. Evaluation of antioxidant activity, total phenolic content, total flavonoids, and LC-MS characterization of Saraca asoca (Roxb.) De. Wilde. Int J Adv Res (Indore) 2015; 3(5): 318-27.
[135]
Gupta M, Sasmal S, Mukherjee A. Study of antinociceptive, antipyretic and anti-inflammatory activities of the methanol extract of saraca asoca. Int J Pharmacol Toxicol Sci 2013; 3(6): 1-11.
[136]
Kshirsagar R, Upadhyay S. Free radical scavenging activity screening of medicinal plants from Tripura. Northeast India 2009.
[137]
Kumar S, Narwal S, Kumar D, Singh G, Narwal S, Arya R. Evaluation of antihyperglycemic and antioxidant activities of Saraca asoca (Roxb.) De Wild leaves in streptozotocin induced diabetic mice. Asian Pac J Trop Dis 2012; 2(3): 170-6.
[http://dx.doi.org/10.1016/S2222-1808(12)60041-3]
[138]
Katiyar S, Patidar D, Gupta S, Singh RK, Singh P. Some Indian traditional medicinal plants with antioxidant activity: a review. Int J Innov Res Sci Eng Technol 2013; 2: 7303-14.
[139]
Sethi S, Gupta S, Hishu A, Rastogi S. Evaluation of antioxidant activity of some medicinal plants. World J Pharm Pharm Sci 2013; 3: 1488-98.
[140]
Jinu MV, Gini CK, Jayabaskaran C. In vitro antioxidant activity of cholestanol glucoside from an endophytic fungus Lasiodiplodia theobromae isolated from Saraca asoca. J Chem Pharm Res 2015; 7(1): 952-62.
[141]
Sharma HK, Gogoi B, Nainwal LM. A review on some antioxidant plant species growing in North East India. Int J Pharm Sci Res 2016; 37: 224-9.
[142]
Tresina PS, Paulpriya K, Sornalakshmi V, Mohan VR. Antioxidant activity of Saraca asoca (Roxb.) Wilde flower: An in vitroevaluation. Int J Pharmacogn Phytochem Res 2018; 10(4): 139-45.
[143]
Mohammed R. Ashour , Abou Zeid A, Sabry O, El Hawary S. Saraca indica L. leaves, phytochemical, in vitro antioxidant and cytotoxic activities. Egypt J Chem 2020; 0(0): 0.
[http://dx.doi.org/10.21608/ejchem.2020.23139.2371]
[144]
Nath D, Mukhopadhyay MK, Shaw M. Chemopreventive potential of major flavonoid compound of methanolic bark extract of Saraca asoca (Roxb.) in benzene -induced toxicity of acute myeloid leukemia mice. Pharmacogn Mag 2017; 13(50) (Suppl. 2): 216.
[http://dx.doi.org/10.4103/pm.pm_326_15] [PMID: 28808383]
[145]
Sherin DR, Manojkumar TK. Flavanoids from Saraca asoca-ideal medication for breast cancer-a molecular simulation approach. Biomed J Sci Tech Res 2017; 1(6): 1761-3.
[146]
Patra N, Kar D, Pal A, Behera A. Antibacterial, anticancer, anti-diabetic and catalytic activity of bio-conjugated metal nanoparticles. Adv Nat Sci 2018; 9(3): 035001.
[http://dx.doi.org/10.1088/2043-6254/aad12d]
[147]
Jaybhaye S. Green synthesis of silver nanoparticles and its antimicrobial activity. J Environ Nanotechnol 2013; 2(1): 47-51.
[148]
Jinu MV, Jayabaskaran C. Diversity and anticancer activity of endophytic fungi associated with the medicinal plant Saraca asoca. Curr Res Environ Appl Mycol 2015; 5(3): 169-79.
[http://dx.doi.org/10.5943/cream/5/3/2]
[149]
Nag D, Ghosh M, Mukherjee A. Antimutagenic and genoprotective effects of Saraca asoca bark extract. Toxicol Ind Health 2015; 31(8): 696-703.
[http://dx.doi.org/10.1177/0748233713483200] [PMID: 23546395]
[150]
Varghese CD. A study of anticancer principles from Saraca asoca 1993.
[151]
Ghosh S, Majumder M, Majumder S, Ganguly NK, Chatterjee BP. Saracin: A lectin from Saraca indica seed integument induces apoptosis in human T-lymphocytes. Arch Biochem Biophys 1999; 371(2): 163-8.
[http://dx.doi.org/10.1006/abbi.1999.1418] [PMID: 10545202]
[152]
Shashikumara S, Purushotham K, Darshan CL, Kalal BS. Characterization of antidepressant activity of Saraca asoca flower (Roxb.) Wilde in mice subjected to acute restraint stress. Am J Transl Res 2022; 14(7): 5014-23.
[PMID: 35958453]
[153]
Verma A, Jana GK, Sen S, Chakraborty R, Sachan S, Mishra A. Pharmacological evaluation of Saraca indica leaves for central nervous system depressant activity in mice. J Pharm Sci Res 2010; 2(6): 338-43.
[154]
Paramesh R, Sunitha A, Kumar VV, Pooranesan R, Vijayalakshmi M. Evecare (U-3107) as a Uterine Tonic-Pilot Study. Indian Pract 1998; 51(4): 269.
[155]
Ganguli MD, Paramesh R. Clinical evaluation of Evecare syrup in the treatment of infertility in women: An open study. IJCP 2010; 20(11): 767-71.
[156]
Singh SK, Kulkarni KS. Evaluation of the efficacy and safety of Menosan in post-menopausal symptoms: a short-term pilot study. Obstet Gynaecol Today 2002; 12: 727-30.
[157]
Sarkar A, Giri S, Kolhapure S. Evaluation of efficacy and safety of Menosan in the management of postmenopausal syndrome: A prospective, randomized, double blind, placebo-controlled, phase III clinical trial. Med Updat 2004; 12: 41-51.
[158]
Gupta A. An open clinical evaluation of menosan tablets in menopausal syndrome: efficacy and safety study. Indian J Clin Pract 2010; 20(12): 827-32.
[159]
Wasta RI, Duttagupta DS, Jadhav VM, Kadam VJ. Evaluation of in vitro anti-inflammatory activity of ovoutoline liquid formulation against the denaturation of protein 2015.
[160]
Duttagupta DS, Rukhsar M, Wasta I, Milind V. In-vitro antioxidant activity of a polyherbal menopausal formulation: ovoutoline tablet. World J Pharm Pharm Sci 2015; 4(05): 1001-8.
[161]
Shirolkar A, Gahlaut A, Chhillar AK, Dabur R. Quantitative analysis of catechins in Saraca asoca and correlation with antimicrobial activity. J Pharm Anal 2013; 3(6): 421-8.
[http://dx.doi.org/10.1016/j.jpha.2013.01.007] [PMID: 29403849]
[162]
Swar G, Shailajan S, Menon S. Activity based evaluation of a traditional Ayurvedic medicinal plant: Saraca asoca (Roxb.) de Wilde flowers as estrogenic agents using ovariectomized rat model. J Ethnopharmacol 2017; 195: 324-33.
[http://dx.doi.org/10.1016/j.jep.2016.11.038] [PMID: 27884717]
[163]
Gupta M, Majumdar S, Banerjee S, Pal S, Mondal T. A double-blind randomized clinical trial of novel Ayurvedic muco-adhesive extended release vaginal tablet (NA) for treatment of leucorrhea. Int J Clin Obstet Gynaecol 2020; 4(2): 324-33.
[http://dx.doi.org/10.33545/gynae.2020.v4.i2f.545]
[164]
Lahiry S, Bhattacharyya D, Chakraborty A, Sudarshan M, Manna M. Saraca asoca seed extract treatment recovers the trace elements imbalances in experimental murine visceral leishmaniasis. J Parasit Dis 2020; 44(1): 131-6.
[http://dx.doi.org/10.1007/s12639-019-01173-9] [PMID: 32174716]
[165]
Roy A, Lakshmi T, Raghunandhakumar S, Elumalai P, Sarojini K. Evaluation of proapoptotic potential of saraca asoca flower extract on skin cancer cell line. J Pharm Res Int 2021; 436-46.

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