Oxocarbon Acids and their Derivatives in Biological and Medicinal
Chemistry

Amanda      Ratto; John   F.   Honek
doi:10.2174/0929867330666230313141452
Abstract

The biological and medicinal chemistry of the oxocarbon acids 2,3- dihydroxycycloprop-2-en-1-one (deltic acid), 3,4-dihydroxycyclobut-3-ene-1,2-dione (squaric acid), 4,5-dihydroxy-4-cyclopentene-1,2,3-trione (croconic acid), 5,6-dihydroxycyclohex- 5-ene-1,2,3,4-tetrone (rhodizonic acid) and their derivatives is reviewed and their key chemical properties and reactions are discussed. Applications of these compounds as potential bioisosteres in biological and medicinal chemistry are examined. Reviewed areas include cell imaging, bioconjugation reactions, antiviral, antibacterial, anticancer, enzyme inhibition, and receptor pharmacology.
Keywords: Deltic acid, squaric, croconic, rhodizonic, oxocarbon acids, bioisosteres.
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DOI https://dx.doi.org/10.2174/0929867330666230313141452	Print ISSN 0929-8673
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