Title:Molecular Targeting and Novel Therapeutic Approaches against
Fungal Infections
Volume: 23
Issue: 8
关键词:
真菌，麦角甾醇，药物，感染，念珠菌，耐药性。
摘要:
Background: Fungal infections have become a worldwide problem due to
their involvement in numerous diseases. The risk factors for fungal infections are multiple
surgeries, transplant therapies, frequent administration of antibiotics, cancer
treatments, and prosthetic devices. The problem of resistance in fungi against drug
therapies is widespread, becoming a severe health-related problem.
Objective: The study's objective was to identify molecular targets that may open new
paths for fungal treatment.
Methods: Several research and review articles were studied to gather information
regarding the novel mechanism of antifungal drugs. However, identifying novel targets
is challenging due to the similarities between host and fungal cells. Although, the
plasma membrane and cell wall of fungus offer various drug targets that may target to
fight against microbial infections. Unfortunately, biofilm formation and over-expression
of protein are a few mechanisms through which fungi develop resistance.
Results: Despite these problems, several approaches have been working to prevent
and treat fungal infections. Modifying the chemical structure of antifungal drugs may
also improve their activity and pharmacokinetics. In this review article, we have discussed
the molecular targets and novel techniques to be used for the development of
antifungal drugs. In addition, different strategies to overcome resistance in fungi have
also been described.
Conclusion: This article may be helpful for the researchers working on the discovery
and development of new antifungal works for resistance to fungal diseases.
