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Current Drug Discovery Technologies

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ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

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Research Article

Protective Effects of Chrysin on Hippocampal Damage Induced by Chlorpyrifos in Adult Rats

Author(s): Behzad Mesbahzadeh, Abolfazl Hatami-moghaddam, Kobra Naseri, Amir Masoud Jafari-Nozad, Saeed Samarghandian* and Tahereh Farkhondeh*

Volume 20, Issue 4, 2023

Published on: 11 April, 2023

Article ID: e020323214241 Pages: 7

DOI: 10.2174/1570163820666230302093111

Price: $65

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Abstract

Objective: This study aimed to evaluate the possible effects of chlorpyrifos on the rat hippocampus and evaluate whether these effects can be decreased with chrysin co-administration in an animal model.

Methods: Male Wistar rats were randomly divided into 5 groups; Control (C), Chlorpyrifos (CPF), Chlorpyrifos + Chrysin (12.5 mg/kg) (CPF + CH1), Chlorpyrifos + Chrysin (25 mg/kg) (CPF + CH2), Chlorpyrifos + Chrysin (50 mg/kg) (CPF + CH3). After 45 days, hippocampus tissues were evaluated by biochemical and histopathological tests.

Results: Biochemical findings indicated that CPF and CPF plus CH administration could not significantly change SOD activity, and MAD, GSH, and NO levels in the hippocampus tissue of animals versus controls. Histopathological findings of the toxic effects of CPF on hippocampus tissue as evidenced by inflammatory cell infiltration, degeneration/necrosis, and mild hyperemia. CH could ameliorate these histopathological changes in a dose-dependent manner.

Conclusion: In conclusion, CH was effective against histopathological damage induced by CPF in the hippocampus through modulating inflammation and apoptosis.

Keywords: Chlorpyrifos, chrysin, sub-chronic, hippocampus, rat, modulating inflammation.

Graphical Abstract

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