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Review Article

Synthesis and SAR of Potential Anti-Cancer Agents of Quinoline Analogues: A Review

Author(s): Sonakshi Tyagi, Salahuddin*, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Km Shabana, Mohammad Shahar Yar and Mohamed Jawed Ahsan

Volume 19, Issue 8, 2023

Published on: 31 March, 2023

Page: [785 - 812] Pages: 28

DOI: 10.2174/1573406419666230228140619

Price: $65

Open Access Journals Promotions 2
Abstract

Quinoline has recently become an important heterocyclic molecule due to its numerous industrial and synthetic organic chemistry applications. Quinoline derivatives have been used in clinical trials for a variety of medical conditions that causes cancer. The present literature study is composed of recent progress (mainly from 2010 to the present) in the production of novel quinoline derivatives as potential anti-cancer agents, as well as their structure-activity relationship, which will provide insight into the development of more active quinoline hybrids in the future.

The present review comprises the synthetic protocols of biologically active Quinoline analogs with their structure-activity relationship studies as anti-cancer agents, which provide depth view of work done on quinoline derivatives to the medicinal chemist for future research.

Keywords: Cancer, quinoline, synthetic approach, anti-cancer activity, cancer cell lines, structure-activity relationship.

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