A Review: Drug Excipient Iincompatiblity by Ftir Spectroscopy

Chander      Singh; Komal      Rao; Nikita      Yadav; Nidhi      Bansal; Yogesh      Vashist; Shalini      Kumari; Palak      Chugh

doi:10.2174/1573412919666230228102158

Abstract

For the development of various formulations, it is necessary to check out the drug excipient incompatibility. Whether the drug is compatible with the excipient or not. Because the drug excipient interaction study provides stability data of the drug and shelf life of the drug. Fourier transform infrared spectroscopy is the best method to evaluate the drug excipient incompatibility study. The FTIR spectroscopy theory is based on the idea that molecules have a tendency to absorb particular light frequencies that are unique to the corresponding structure of the molecules. The energies depend on the atomic masses, the related vibronic coupling, and the geometry of the molecular surfaces. For instance, the molecule may be able to absorb the energy present in the incident light, which will cause it to rotate more quickly or vibrate more loudly. In this article, a list of various drugs with different excipients was discussed. This review emphasizes on various examples of drug interaction with a number of excipients on the basis of Fourier Transform infrared spectroscopy data which is based on last 10-12 year research paper, and the principle ,working, applications of infrared spectroscopy were also discussed.

Keywords: Drug excipient incompatibility, IR spectroscopy, FTIR, Spectra, vibration, interaction, drug quality control, electromagnetic (EM) radiation.

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DOI https://dx.doi.org/10.2174/1573412919666230228102158	Print ISSN 1573-4129
Publisher Name Bentham Science Publisher	Online ISSN 1875-676X

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A Review: Drug Excipient Iincompatiblity by Ftir Spectroscopy

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