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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

A Short Review of Antimalarial Compounds with Sulfonamide Moiety

Author(s): Leonardo C. Dantas, Vinicius R. Campos, Julio C. Borges and Luiz C.S. Pinheiro*

Volume 23, Issue 21, 2023

Published on: 31 March, 2023

Page: [2073 - 2088] Pages: 16

DOI: 10.2174/1389557523666230227113231

Price: $65

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Abstract

Malaria is a public health problem that causes thousands of deaths, primarily in children in African regions. Artemisinin-based combination therapies (ACTs) have helped to save thousands of lives; however, due to Plasmodium's resistance to available treatments, there is a need to search for new low-cost drugs that act through different mechanisms of action to contain this disease. This review shows that compounds with sulfonamide moiety, possibly, act as inhibitors of P. falciparum carbonic anhydrases, moreover, when linked to a variety of heterocycles potentiate the activities of these compounds and may be used in the design of new antimalarial drugs.

Keywords: Malaria, sulfonamide, Plasmodium falciparum, carbonic anhydrase, antimalarial drugs, PfCA.

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