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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Mini-Review Article

The Synthetic Progress of Fused Bicyclic N,O-acetals

Author(s): Shuyan Yu*, Zeyu Liu, Hongbing Lan, Kun Qian, Xiaohua Ding* and Zhigang Yin

Volume 26, Issue 24, 2022

Published on: 24 February, 2023

Page: [2203 - 2213] Pages: 11

DOI: 10.2174/1385272827666230217090408

Price: $65

Open Access Journals Promotions 2
Abstract

Owing to the prevalent occurring in natural products and abundant bioactivities, the effective synthetic methods of fused bicyclic N,O-acetals skeletons are of great interest to chemists. This mini-review summarized the thus far synthetic progress of fused bicyclic N,O-acetals. These works were elaborated according to the different reaction types, including a) hetero-Diels-Alder cycloaddition of cyclic enamines with oxadienes; b) step-by-step reactions between cyclic enamines and electrophiles with pendant hydroxyl groups; c) [3+2] cycloaddition of indole with quinone or its equivalent and d) other novel strategies. The catalytic systems and reaction mechanisms are mainly described.

Keywords: N, O-acetals, hetero-Diels-Alder (hetero-DA), multicomponent domino reaction (MCR), hydroxyl groups, cyclic enamines, cycloaddition.

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