Title:Exosomal miRNAs as Next-generation Therapy Vehicles in Breast Cancer
Volume: 23
Issue: 5
Author(s): Priyanka Thakur, Harshita Dahiya, Ankur Kaushal, Vijai Kumar Gupta, Adesh K. Saini and Reena V. Saini*
Affiliation:
- Department of Biotechnology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana-
Ambala, 133207, Haryana, India
- Central Research Laboratory, MM Institute of Medical Sciences & Research,
Maharishi Markandeshwar (Deemed to be University), Mullana, 133207, Haryana, India
Keywords:
Exosomal miRNAs, breast cancer, therapeutic biomarkers, metastasis, chemoresistance, target genes.
Abstract: The second most pervasive cancer affecting the survival of women across the world is
breast cancer. One of the biggest challenges in breast cancer treatment is the chemoresistance of cancer
cells to various medications after some time. Therefore, highly specific blood-based biomarkers
are required for early breast cancer diagnosis to overcome chemoresistance and improve patient survival.
These days, exosomal miRNAs have attracted much attention as early diagnostic blood-based
biomarkers because of their high stability, secretion from malignant tumor cells, and excellent specificity
for different breast cancer subtypes. In addition, exosomal miRNAs regulate cell proliferation,
invasion, metastasis, and apoptosis by binding to the 3′UTR of their target genes and limiting their
production. This review focuses on the functions of exosomal miRNAs in tumorigenesis via targeting
multiple signaling pathways as well as chemosensitivity and resistance mechanisms. In addition, the
growing pieces of evidence discussed in this review suggest that circulating exosomal miRNAs could
be utilized as potential next-generation therapeutic target vehicles in the treatment of breast cancer.