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Current Drug Safety

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ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

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Case Report

Ferric Carboxymaltose-mediated Methemoglobinemia

Author(s): Muhammet Özbilen*, Şeyda Tuba Savrun, Ali Aygün and Yasemin Kaya

Volume 19, Issue 1, 2024

Published on: 03 March, 2023

Page: [134 - 137] Pages: 4

DOI: 10.2174/1574886318666230213111038

Price: $65

Abstract

Background: Methemoglobinemia is a life-threatening disorder, with levels above 1 percent considered abnormal and typically resulting from drug or toxic substance exposure.

Case Presentation: In this study, we describe a case of a 43-year-old woman with a long-standing complaint of fatigue. Iron deficiency anemia was diagnosed based on the blood test findings of hemoglobin of 101 g/L, mean red blood cell volume of 75 fL, ferritin of 2.81 ug/L, transferrin saturation of 4.3 percent, and C-reactive protein of 0.6 mg/L. As a preferred treatment option, 1000 mg ferric carboxymaltose on two distinct days was preferred. After administering the first dose of the medication, we noticed incidentally that methemoglobin levels increased to 2.3%. When venous blood gas was repeated before and after administration of the second dose of the drug, methemoglobin levels were found to be 0.8% and 1.8%, respectively. There was no change in vital signs in both two dosages, and she only suffered a temporary sore throat. Her anemia improved with intravenous iron therapy, and she is currently being followed in our clinic.

Conclusion: No case or research reporting an increase in methemoglobin levels following oral and/or intravenous treatment to patients with iron deficiency anemia has been found in the literature. Therefore, this is the first contribution to the existing literature.

Keywords: Iron deficiency, anemia, intravenous iron, ferric carboxymaltose, side effect, methemoglobinemia.

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