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Current Drug Safety

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ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

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Cross-Sectional Study

Vitamin D Deficiency in Advanced Laryngeal Cancer and its Association with Pharyngocutaneous Fistula Following Total Laryngectomy

Author(s): Kamyar Iravani*, Yaaghoob Khosravi, Aida Doostkam and Amir Soltaniesmaeili

Volume 19, Issue 1, 2024

Published on: 03 May, 2023

Page: [129 - 133] Pages: 5

DOI: 10.2174/1574886318666230331100122

Price: $65

Abstract

Background: Nutritional factors in developing some malignancies have been investigated recently.

Objective: In this study, we evaluated the role of vitamin D in advanced laryngeal cancer and its association with the development of pharyngocutaneous fistula (PCF) following total laryngectomy.

Study Design: A cross-sectional, case-control study was conducted.

Methods: Fifty-five patients with advanced laryngeal cancer referred for total laryngectomy were included. We also considered 55 healthy individuals after matching age and sex as a control group. Serum levels of 25(OH)D3 were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The association of serum 25(OH)D3 with PCF following total laryngectomy was also determined.

Results: Vitamin D was significantly lower in patients with advanced laryngeal cancer than in the control group (p < 0.001). Moreover, our results showed that a mean serum concentration of 25(OH)D3 in patients with PCF was significantly lower than in patients without PCF (p < 0.001).

Conclusion: Vitamin D deficiency is highly prevalent in advanced laryngeal cancer, most pronounced in those who develop a PFC following total laryngectomy.

Keywords: Fistula, laryngeal neoplasms, risk factors, respiratory tract fistula, vitamin D, pharyngocutaneous fistula.

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Graphical Abstract

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