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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

Regeneration of Aryl Ketones by Oxidative Cleavage of Pyridyl Hydrazones Mediated by Koser’s Reagent

Author(s): Monika Sihag, Rinku Soni, Neha Rani, Mayank Kinger and Deepak Kumar Aneja*

Volume 20, Issue 8, 2023

Published on: 08 March, 2023

Page: [696 - 700] Pages: 5

DOI: 10.2174/1570178620666230209145324

Price: $65

Abstract

[Hydroxy(tosyloxy)iodo]benzene mediated the oxidative cleavage of pyridyl hydrazones to regenerate aryl ketones efficiently. Reaction occurred by simply stirring the hydrazone with hypervalent iodine reagent in dichloromethane at room temperature, where aryl ketones are produced up to 90% yield.

Keywords: Aryl ketones, hypervalent iodine reagent, oxidative cleavage, protecting group, pyridyl hydrazones, HTIB.

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