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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

Advances in Ovarian Cancer Treatment Beyond PARP Inhibitors

Author(s): Fine Aliyuda, Michele Moschetta, Aruni Ghose, Kathrine Sofia Rallis, Matin Sheriff, Elisabet Sanchez, Elie Rassy and Stergios Boussios*

Volume 23, Issue 6, 2023

Published on: 13 March, 2023

Page: [433 - 446] Pages: 14

DOI: 10.2174/1568009623666230209121732

Price: $65

Abstract

Ovarian cancer has become the largest cause of gynaecological cancer-related mortality. It is typically diagnosed at a late stage and has no effective screening strategy. Ovarian cancer is a highly heterogeneous disease that can be subdivided into several molecular subsets. As a result of a greater understanding of molecular pathways involved in carcinogenesis and tumor growth, targeted agents have been approved or are in several stages of development. Poly(ADP-ribose) polymerase (PARP) inhibitors and the anti-vascular endothelial growth factor (VEGF)-A antibodies are two types of approved and most effective targeted drugs for ovarian cancer at present. With the success of bevacizumab, tyrosine kinase inhibitors which could target alternate angiogenic pathways are being studied. Furthermore, many treatments targeting the PI3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathways, are being developed or are already in clinical studies. MicroRNAs have also become novel biomarkers for the therapy and clinical diagnosis of ovarian cancer. This manuscript reviews the molecular, preclinical and clinical evidence supporting the targeting of growth-dependent pathways in ovarian cancer and assesses current data related to targeted treatments beyond PARP inhibitors.

Keywords: Ovarian cancer, angiogenesis inhibitors, EGFR inhibitors, PI3K inhibitors, AKT inhibitors, miRNA-related targets.

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