Login Register Cart 0
Generic placeholder image

Current Cancer Drug Targets

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe Translate in Chinese
Review Article

Lycopene as a Potential Bioactive Compound: Chemistry, Extraction, and Anticancer Prospective

Author(s): Reema Abu Khalaf* and Maha Awad

Volume 23, Issue 8, 2023

Published on: 27 February, 2023

Page: [634 - 642] Pages: 9

DOI: 10.2174/1568009623666230131124236

Price: $65

Open Access Journals Promotions 2
Abstract

Lycopene, a potential bioactive agent, is a non-pro-vitamin A carotenoid recognized as a potent antioxidant. It is extracted from plants like tomatoes, watermelons, red carrots and papayas and has remarkable health benefits. A significant amount of research has been assisted to date to establish the anticancer activity of lycopene. Our review enhances information about the promising anticancer potential of this compound. The biological activity of lycopene has been described in several studies in regard to pancreatic, breast, prostate, liver, gastric, ovarian, kidney, skin, intestine, brain and spinal cord cancers. Lycopene resists cancer by inhibition of apoptosis, induction of cell proliferation, cell invasion, cell cycle development, metastasis and angiogenesis. The mechanisms of anticancer action of lycopene are attributed to the management of certain signal transduction pathways, such as modulation of insulin-like growth factors system, PI3K/Akt pathway, modification of important gene expression, inhibit the activity of sex steroid hormones, and the conversation of mitochondrial behavior. Hence, this review focuses on current knowledge of sources, extraction techniques, and chemistry of lycopene, as well as the prospective mechanisms of action related with its anticancer activity. Also, it summarizes the background information about lycopene and the most current research with consideration to its aspect in treating several types of cancer together with future directions.

Keywords: Lycopene, cancer treatment, carotenoids, anticancer agent, extraction, antioxidant.

« Previous Next »
Graphical Abstract

Molecules Bardaweel S. 27 2887 2022 10.3390/molecules27092887 Bardaweel S.; Aljanabi R.; Sabbah D.; Sweidan K.; Design, synthesis, and biological evaluation of novel MAO-A inhibitors targeting lung cancer. Molecules 2022,27(9),2887 Antioxidants Cheng J. 9 643 2020 10.3390/antiox9070643 Cheng J.; Miller B.; Balbuena E.; Eroglu A.; Lycopene protects against smoking-induced lung cancer by inducing base excision repair. Antioxidants 2020,9(7),643 Biomed Pharmacother Qi W.J. 138 111546 2021 10.1016/j.biopha.2021.111546 Qi W.J.; Sheng W.S.; Peng C.; Xiaodong M.; Yao T.Z.; Investigating into anti-cancer potential of lycopene: Molecular targets. Biomed Pharmacother 2021,138,111546 Biomed Pharmacother Chen D. 111 791 2019 10.1016/j.biopha.2018.12.151 Chen D.; Huang C.; Chen Z.; A review for the pharmacological effect of lycopene in central nervous system disorders. Biomed Pharmacother 2019,111,791-801 Genet Mol Res Peng S.J. 16 13 2017 10.4238/gmr16029434 Peng S.J.; Li J.; Zhou Y.; Tuo M.; Qin X.X.; Yu Q.; Cheng H.; Li Y.M.; In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells. Genet Mol Res 2017,16(2),13 Antioxidants Arballo J. 10 342 2021 10.3390/antiox10030342 Arballo J.; Amengual J.; Erdman J.W.; Jr Lycopene: A critical review of digestion, absorption, metabolism, and excretion. Antioxidants 2021,10(3),342 Int J Food Prop Choksi P.M. 10 289 2007 10.1080/10942910601052699 Choksi P.M.; Joshi V.Y.; A review on lycopene—extraction, purification, stability and applications. Int J Food Prop 2007,10(2),289-298 Molecules Rauf A. 26 7368 2021 10.3390/molecules26237368 Rauf A.; Abu-Izneid T.; Khalil A.A.; Imran M.; Shah Z.A.; Emran T.B.; Mitra S.; Khan Z.; Alhumaydhi F.A.; Aljohani A.S.M.; Khan I.; Rahman M.M.; Jeandet P.; Gondal T.A.; Berberine as a potential anticancer agent: A comprehensive review. Molecules 2021,26(23),7368 Food Chem Briones-Labarca V. 278 751 2019 10.1016/j.foodchem.2018.11.106 Briones-Labarca V.; Giovagnoli-Vicuña C.; Cañas-Sarazúa R.; Optimization of extraction yield, flavonoids and lycopene from tomato pulp by high hydrostatic pressure-assisted extraction. Food Chem 2019,278,751-759 J Funct Foods Reshmitha T.R. 28 147 2017 10.1016/j.jff.2016.10.031 Reshmitha T.R.; Thomas S.; Geethanjali S.; Arun K.B.; Nisha P.; DNA and mitochondrial protective effect of lycopene rich tomato (Solanum lycopersicum L.) peel extract prepared by enzyme assisted extraction against H2O2 induced oxidative damage in L6 myoblasts. J Funct Foods 2017,28,147-156 Sci Rep Priyadarsani S. 11 10273 2021 10.1038/s41598-021-89772-6 Priyadarsani S.; Patel A.S.; Kar A.; Dash S.; Process optimization for the supercritical carbondioxide extraction of lycopene from ripe grapefruit (Citrus paradisi) endocarp. Sci Rep 2021,11(1),10273 Green Chem de Souza Mesquita L.M. 21 2380 2019 10.1039/C8GC03283A de Souza Mesquita L.M.; Ventura S.P.M.; Braga A.R.C.; Pisani L.P.; Dias A.C.R.V.; de Rosso V.V.; Ionic liquid-high performance extractive approach to recover carotenoids from Bactris gasipaes fruits. Green Chem 2019,21(9),2380-2391 Antioxidants Mihalcea L. 10 1681 2021 10.3390/antiox10111681 Mihalcea L.; Turturică M.; Cucolea E.I.; Dănilă G.M.; Dumitrașcu L.; Coman G.; Constantin O.E.; Grigore-Gurgu L.; Stănciuc N.; CO2 Supercritical fluid extraction of oleoresins from sea buckthorn pomace: Evidence of advanced bioactive profile and selected functionality. Antioxidants 2021,10(11),1681 Antioxidants Maher T. 10 1612 2021 10.3390/antiox10101612 Maher T.; Kabbashi N.A.; Mirghani M.E.S.; Alam M.Z.; Daddiouaissa D.; Abdulhafiz F.; Reduan M.F.H.; Omran J.I.; Abdul Razab M.K.A.; Mohammed A.; Optimization of ultrasound-assisted extraction of bioactive compounds from Acacia Seyal Gum using response surface methodology and their chemical content identification by raman, FTIR, and GC-TOFMS. Antioxidants 2021,10(10),1612 Food Eng Rev Lara-Abia S. 13 660 2021 10.1007/s12393-021-09289-6 Lara-Abia S.; Gomez-Maqueo A.; Welti-Chanes J.; Cano M.P.; High hydrostatic pressure-assisted extraction of carotenoids from papaya (Carica papaya L. cv. Maradol) tissues using soybean and sunflower oil as potential green solvents. Food Eng Rev 2021,13(3),660-675 J Pure Appl Microbiol Tayal N. 13 567 2019 10.22207/JPAM.13.1.64 Tayal N.; Srivastava P.; Srivastava N.; Srivastava N.; Anti angiogenic activity of Carica papaya leaf extract. J Pure Appl Microbiol 2019,13(1),567-571 J Food Biochem Ghosh S. 45 e13833 2021 10.1111/jfbc.13833 Ghosh S.; Nandi S.; Banerjee A.; Sarkar S.; Chakraborty N.; Acharya K.; Prospecting medicinal properties of Lion’s mane mushroom. J Food Biochem 2021,45(8),e13833 Int J Res Pharmaceut Sci Khatua S. 10 564 2019 Khatua S.; Ghosh S.; Acharya K.; Antioxidant properties and metabolites profiling of polyphenol-rich fraction from a folk mushroom, Macrocybe lobayensis, using different extractant. Int J Res Pharmaceut Sci 2019,10(1),564-571 Food Res Int Vasconcelos A.G. 99 959 2017 10.1016/j.foodres.2017.01.017 Vasconcelos A.G.; Amorim A.G.N.; dos Santos R.C.; Souza J.M.T.; de Souza L.K.M.; Araújo T.S.L.; Nicolau L.A.D.; de Lima Carvalho L.; de Aquino P.E.A.; da Silva Martins C.; Ropke C.D.; Soares P.M.G.; Kuckelhaus S.A.S.; Medeiros J.V.R.; Leite J.R.S.A.; Lycopene rich extract from red guava (Psidium guajava L.) displays anti-inflammatory and antioxidant profile by reducing suggestive hallmarks of acute inflammatory response in mice. Food Res Int 2017,99(Pt 2),959-968 Veterin Med Int Meles D.K. 2021 9931001 2021 Meles D.K.; Mustofa I.; Wurlina W.; Susilowati S.; Utama S.; Suwasanti N.; Putri D. K.; The restorative effect of red guava (Psidium guajava L.) fruit extract on pulmonary tissue of rats (Rattus norvegicus) exposed to cigarette smoke. Veterin Med Int 2021,2021,9931001 Cancer Nanotechnol Vasconcelos A.G. 12 1 2021 10.1186/s12645-021-00103-w Vasconcelos A.G.; Barros A.L.A.; Cabral W.F.; Moreira D.C.; da Silva I.G.M.; Silva-Carvalho A.É.; de Almeida M.P.; Albuquerque L.F.; dos Santos R.C.; Brito S.; Promising self-emulsifying drug delivery system loaded with lycopene from red guava (Psidium guajava L.): In vivo toxicity, biodistribution and cytotoxicity on DU-145 prostate cancer cells. Cancer Nanotechnol 2021,12(1),1-29 Food Chem Lu Q. 232 788 2017 10.1016/j.foodchem.2017.04.064 Lu Q.; Huang X.; Lv S.; Pan S.; Carotenoid profiling of red navel orange “Cara Cara” harvested from five regions in China. Food Chem 2017,232,788-798 Int J Food Prop Lu Q. 21 1107 2018 10.1080/10942912.2018.1485030 Lu Q.; Lv S.; Peng Y.; Zhu C.; Pan S.; Characterization of phenolics and antioxidant abilities of red navel orange “Cara Cara” harvested from five regions of China. Int J Food Prop 2018,21(1),1107-1116 Plant Cell Rep Jo S.H. 40 1793 2021 10.1007/s00299-021-02741-1 Jo S.H.; Park H.J.; Lee A.; Jung H.; Min S.R.; Lee H.J.; Kim H.S.; Jung M.; Hyun J.Y.; Kim Y.S.; Cho H.S.; A single amino acid insertion in LCYB2 deflects carotenoid biosynthesis in red carrot. Plant Cell Rep 2021,40(9),1793-1795 Food Chem Zhou W. 330 127223 2020 10.1016/j.foodchem.2020.127223 Zhou W.; Niu Y.; Ding X.; Zhao S.; Li Y.; Fan G.; Zhang S.; Liao K.; Analysis of carotenoid content and diversity in apricots (Prunus armeniaca L.) grown in China. Food Chem 2020,330,127223 J Food Biochem Kumari G.U.W.U.P. 44 e13499 2020 10.1111/jfbc.13499 Kumari G.U.W.U.P.; Gunathilake K.D.P.P.; In vitro bioaccessibility and antioxidant activity of black plum (Syzygium caryophyllatum). J Food Biochem 2020,44(12),e13499 Int J Chemtech Res Acharya K. 10 126 2017 Acharya K.; Ghosh S.; Saha T.; Physicochemical characterization and antioxidant property of powdered basidiocarp of wild Lentinus sajor-caju. Int J Chemtech Res 2017,10(1),126-1327 Elixir Appl Botany Owoade A.O. 121 51556 2018 Owoade A.O.; Adetutu A.; Olorunnisola O.S.; Ayinde K.S.; The in-vitro antioxidant properties and phytochemical constituents of citrullus colocynthis methanolic extract. Elixir Appl Botany 2018,121,51556-51562 Food Chem Oberoi D.P.S. 232 316 2017 10.1016/j.foodchem.2017.04.038 Oberoi D.P.S.; Sogi D.S.; Utilization of watermelon pulp for lycopene extraction by response surface methodology. Food Chem 2017,232,316-321 C R Chim Aissou M. 20 346 2017 10.1016/j.crci.2016.05.018 Aissou M.; Chemat-Djenni Z.; Yara-Varón E.; Fabiano-Tixier A.S.; Chemat F.; Limonene as an agro-chemical building block for the synthesis and extraction of bioactive compounds. C R Chim 2017,20(4),346-358 Metab Eng Ma T. 52 134 2019 10.1016/j.ymben.2018.11.009 Ma T.; Shi B.; Ye Z.; Li X.; Liu M.; Chen Y.; Xia J.; Nielsen J.; Deng Z.; Liu T.; Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene. Metab Eng 2019,52,134-142 Bioprocess Biosyst Eng Xu X. 44 1033 2021 10.1007/s00449-020-02503-5 Xu X.; Liu J.; Lu Y.; Lan H.; Tian L.; Zhang Z.; Xie C.; Jiang L.; Pathway engineering of Saccharomyces cerevisiae for efficient lycopene production. Bioprocess Biosyst Eng 2021,44(6),1033-1047 J Agric Food Chem Su A. 66 5879 2018 10.1021/acs.jafc.8b00855 Su A.; Chi S.; Li Y.; Tan S.; Qiang S.; Chen Z.; Meng Y.; Metabolic redesign of Rhodobacter sphaeroides for lycopene production. J Agric Food Chem 2018,66(23),5879-5885 Bioprocess Biosyst Eng Xu J. 41 489 2018 10.1007/s00449-017-1883-y Xu J.; Xu X.; Xu Q.; Zhang Z.; Jiang L.; Huang H.; Efficient production of lycopene by engineered E. coli strains harboring different types of plasmids. Bioprocess Biosyst Eng 2018,41(4),489-499 Bioresour Technol Wei Y. 250 382 2018 10.1016/j.biortech.2017.11.035 Wei Y.; Mohsin A.; Hong Q.; Guo M.; Fang H.; Enhanced production of biosynthesized lycopene via heterogenous MVA pathway based on chromosomal multiple position integration strategy plus plasmid systems in Escherichia coli. Bioresour Technol 2018,250,382-389 Biosci Biotechnol Biochem Zhang X. 84 463 2020 10.1080/09168451.2019.1693250 Zhang X.; Wang D.; Duan Y.; Zheng X.; Lin Y.; Liang S.; Production of lycopene by metabolically engineered Pichia pastoris. Biosci Biotechnol Biochem 2020,84(3),463-470 Indian J Exper Biol Hernández-Almanza A. 55 479 2017 Hernández-Almanza A.; Navarro-Macías V.; Aguilar O.; Aguilar-González M.A.; Aguilar C.N.; Carotenoids extraction from Rhodotorula glutinis cells using various techniques: A comparative study. Indian J Exper Biol 2017,55(7),479-484 Bioorg Chem Jinendiran S. 103 104149 2020 10.1016/j.bioorg.2020.104149 Jinendiran S.; Dahms H.U.; Dileep Kumar B.S.; Kumar Ponnusamy V.; Sivakumar N.; Diapolycopenedioic-acid-diglucosyl ester and keto-myxocoxanthin glucoside ester: Novel carotenoids derived from Exiguobacterium acetylicum S01 and evaluation of their anticancer and anti-inflammatory activities. Bioorg Chem 2020,103,104149 Eur J Biomed Pharm Sci Ramanathan G. 4 330 2017 Ramanathan G.; Ramalakshmi P.; Studies on efficacy of marine bacterium Salinicoccus roseus pigment for their bioactive potential. Eur J Biomed Pharm Sci 2017,4,330-334 J Appl Microbiol Guo W. 123 1214 2017 10.1111/jam.13581 Guo W.; Li D.; He R.; Wu M.; Chen W.; Gao F.; Zhang Z.; Yao Y.; Yu L.; Chen S.; Synthesizing value-added products from methane by a new Methylomonas. J Appl Microbiol 2017,123(5),1214-1227 J Chromatogr A Zhao C. 1514 120 2017 10.1016/j.chroma.2017.07.074 Zhao C.; Yang Y.; Wei L.; Guo Q.; Fang H.; Chen S.; Hua Q.; Simultaneous determination of intracellular nucleotides and coenzymes in Yarrowia lipolytica producing lipid and lycopene by capillary zone electrophoresis. J Chromatogr A 2017,1514,120-126 J Supercrit Fluids Sovová H. 148 93 2019 10.1016/j.supflu.2019.03.002 Sovová H.; Stateva R.P.; New developments in the modelling of carotenoids extraction from microalgae with supercritical CO2. J Supercrit Fluids 2019,148,93-103 Comput Struct Biotechnol J Park S. 19 1531 2021 10.1016/j.csbj.2021.03.007 Park S.; Cho S.W.; Lee Y.; Choi M.; Yang J.; Lee H.; Seo S.W.; Engineering Vibrio sp. SP1 for the production of carotenoids directly from brown macroalgae. Comput Struct Biotechnol J 2021,19,1531-1540 Lycopene production by mated fermentation of Blakeslea trispora Microbial carotenoids Martínez-Cámara S. 257 2018 10.1007/978-1-4939-8742-9_15 Martínez-Cámara S.; Rubio S.; Río H.d.; Rodríguez-Sáiz M.; Barredo J-L.; Lycopene production by mated fermentation of Blakeslea trispora Microbial carotenoids 2018,257-268 Appl Microbiol Biotechnol Mantzouridou F.T. 101 1845 2017 10.1007/s00253-016-7943-4 Mantzouridou F.T.; Naziri E.; Scale translation from shaken to diffused bubble aerated systems for lycopene production by Blakeslea trispora under stimulated conditions. Appl Microbiol Biotechnol 2017,101(5),1845-1856 Front Pharmacol Singla R.K. 12 732266 2021 10.3389/fphar.2021.732266 Singla R.K.; Sharma P.; Dubey A.K.; Gundamaraju R.; Kumar D.; Kumar S.; Madaan R.; Shri R.; Tsagkaris C.; Parisi S.; Joon S.; Singla S.; Kamal M.A.; Shen B.; Natural product-based studies for the management of castration-resistant prostate cancer: Computational to clinical studies. Front Pharmacol 2021,12,732266 Asian J Androl Jiang L-N. 21 80 2018 Jiang L-N.; Liu Y-B.; Li B-H.; Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression. Asian J Androl 2018,21(1),80-85 Antioxidants Dulińska-Litewka J. 10 585 2021 10.3390/antiox10040585 Dulińska-Litewka J.; Sharoni Y.; Hałubiec P.; Łazarczyk A.; Szafrański O.; McCubrey J.A.; Gąsiorkiewicz B.; Laidler P.; Bohn T.; Recent progress in discovering the role of carotenoids and their metabolites in prostatic physiology and pathology with a focus on prostate cancer—A review—Part I: Molecular mechanisms of carotenoid action. Antioxidants 2021,10(4),585 Anticancer Res Mokbel K. 39 5231 2019 10.21873/anticanres.13720 Mokbel K.; Wazir U.; Mokbel K.; Chemoprevention of prostate cancer by natural agents: evidence from molecular and epidemiological studies. Anticancer Res 2019,39(10),5231-5259 Pharmaceuticals (Basel) Fort R. 11 78 2018 10.3390/ph11030078 Fort R.; Trinidad Barnech J.; Dourron J.; Colazzo M.; Aguirre-Crespo F.; Duhagon M.; Álvarez G.; Isolation and structural characterization of bioactive molecules on prostate cancer from Mayan traditional medicinal plants. Pharmaceuticals (Basel) 2018,11(3),78 Asian J Pharm Clin Res Venugopal J. 10 17 2017 10.22159/ajpcr.2017.v10i12.21039 Venugopal J.; S, P.; A, R. A review on screening methods of breast cancer, cancer biomarkers and phytoconstituents against breast cancer. Asian J Pharm Clin Res 2017,10(12),17-21 J Agric Food Chem Arathi B.P. 66 11362 2018 10.1021/acs.jafc.8b04850 Arathi B.P.; Raghavendra-Rao Sowmya P.; Kuriakose G.C.; Shilpa S.; Shwetha H.J.; Kumar S.; Raju M.; Baskaran V.; Lakshminarayana R.; Fractionation and characterization of lycopene-oxidation products by LC-MS/MS (ESI)+: elucidation of the chemopreventative potency of oxidized lycopene in breast-cancer cell lines. J Agric Food Chem 2018,66(43),11362-11371 Colloids Surf B Biointerfaces Jain A. 152 482 2017 10.1016/j.colsurfb.2017.01.050 Jain A.; Sharma G.; Kushwah V.; Thakur K.; Ghoshal G.; Singh B.; Jain S.; Shivhare U.S.; Katare O.P.; Fabrication and functional attributes of lipidic nanoconstructs of lycopene: An innovative endeavour for enhanced cytotoxicity in MCF-7 breast cancer cells. Colloids Surf B Biointerfaces 2017,152,482-491 Integr Cancer Ther Larouche D. 16 485 2017 Larouche D.; Hanna M.; Chang S-L.; Jacob S.; Tetu B.; Diorio C.; Evaluation of antioxidant intakes in relation to inflammatory markers expression within the normal breast tissue of breast cancer patients. Integr Cancer Ther 2017,16,485-495 J Drug Deliv Sci Technol Mennati A. 66 102806 2021 10.1016/j.jddst.2021.102806 Mennati A.; Rostamizadeh K.; Manjili H.K.; Mousavi M.A.; Zhiani M.; Sabouri I.; Attari E.; Fathi M.; Danafar H.; Synthesis of methoxy poly(ethylene glycol)-poly(ε-caprolactone) diblock copolymers hybridized with DDAB cationic lipid as the efficient nanocarriers for in vitro delivery of lycopene into MCF-7 breast cancer cells. J Drug Deliv Sci Technol 2021,66,102806 Arch Biochem Biophys Mustra Rakic J. 689 108439 2020 10.1016/j.abb.2020.108439 Mustra Rakic J.; Wang X.D.; Role of lycopene in smoke-promoted chronic obstructive pulmonary disease and lung carcinogenesis. Arch Biochem Biophys 2020,689,108439 Front Pharmacol Mekuria A.N. 11 1306 2020 10.3389/fphar.2020.01306 Mekuria A.N.; Tura A.K.; Hagos B.; Sisay M.; Abdela J.; Mishore K.M.; Motbaynor B.; Anti-cancer effects of lycopene in animal models of hepatocellular carcinoma: a systematic review and meta-analysis. Front Pharmacol 2020,11,1306 J Funct Foods Navarro-González I. 42 271 2018 10.1016/j.jff.2018.01.003 Navarro-González I.; García-Alonso J.; Periago M.J.; Bioactive compounds of tomato: Cancer chemopreventive effects and influence on the transcriptome in hepatocytes. J Funct Foods 2018,42,271-280 Anticancer Agents Med Chem Rawat D. 18 1838 2018 Rawat D.; Shrivastava S.; Naik R.A.; Chhonker S.K.; Mehrotra A.; Koiri R. K.; An overview of natural plant products in the treatment of hepatocellular carcinoma. Anticancer Agents Med Chem 2018,18(13),1838-1859 Nutrients Jeong Y. 11 762 2019 10.3390/nu11040762 Jeong Y.; Lim J.; Kim H.; Lycopene inhibits reactive oxygen species-mediated NF-κB signaling and induces apoptosis in pancreatic cancer cells. Nutrients 2019,11(4),762 Pancreatology Tarasiuk A. 19 481 2019 10.1016/j.pan.2019.04.010 Tarasiuk A.; Fichna J.; Effectiveness and therapeutic value of phytochemicals in acute pancreatitis: A review. Pancreatology 2019,19(4),481-487 Anti-cancer Agents Med Chem Khaleel S. 22 1012 2022 Khaleel S.; Al-Hiari Y.; Kasabri V.; Haddadin R.; Albashiti R.; Al-Zweri M.; Bustanji Y.; Antiproliferative Properties of 7,8-Ethylene Diamine Chelator-Lipophilic Fluoroquinolone Derivatives Against Colorectal Cancer Cell Lines. Anti-cancer Agents Med Chem 2022,22,1012-1028 J Biol Regul Homeost Agents Carini F. 31 769 2017 Carini F.; David S.; Tomasello G.; Mazzola M.; Damiani P.; Rappa F.; Battaglia L.; Gerges Geagea A.; Jurjus R.; Leone A.; Colorectal cancer: an update on the effects of lycopene on tumor progression and cell proliferation. J Biol Regul Homeost Agents 2017,31(3),769-774 J Food Biochem Langner E. 43 e12802 2019 10.1111/jfbc.12802 Langner E.; Lemieszek M.K.; Rzeski W.; Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro. J Food Biochem 2019,43(4),e12802 ACS Omega Storniolo C.E. 5 17071 2020 10.1021/acsomega.9b04329 Storniolo C.E.; Sacanella I.; Lamuela-Raventos R.M.; Moreno J.J.; Bioactive compounds of Mediterranean cooked tomato sauce (sofrito) modulate intestinal epithelial cancer cell growth through oxidative stress/arachidonic acid cascade regulation. ACS Omega 2020,5(28),17071-17077 Nutr Res Park B. 70 70 2019 10.1016/j.nutres.2018.07.010 Park B.; Lim J.W.; Kim H.; Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells. Nutr Res 2019,70,70-81 J Physiol Pharmacol Kim M. 70 jpp.2019.4.11. 2019 Kim M.; Kim S.H.; Lim J.W.; Kim H.; Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells. J Physiol Pharmacol 2019,70(4),jpp.2019.4.11. Nutrients Han H. 11 2113 2019 10.3390/nu11092113 Han H.; Lim J.W.; Kim H.; Lycopene inhibits activation of epidermal growth factor receptor and expression of cyclooxygenase-2 in gastric cancer cells. Nutrients 2019,11(9),2113 Mol Cell Probes Xu J. 46 101419 2019 10.1016/j.mcp.2019.07.002 Xu J.; Li Y.; Hu H.; Effects of lycopene on ovarian cancer cell line SKOV3 in vitro: Suppressed proliferation and enhanced apoptosis. Mol Cell Probes 2019,46,101419 Gen Physiol Biophys Kulhan N.G. 38 253 2019 10.4149/gpb_2019006 Kulhan N.G.; Kulhan M.; Turkler C.; Ata N.; Kiremitli T.; Kiremitli S.; Cimen F.K.; Suleyman H.; Toprak V.; Effect of lycopene on oxidative ovarian damage induced by cisplatin in rats. Gen Physiol Biophys 2019,38(3),253-258 Can J Physiol Pharmacol Stojiljković N. 98 111 2020 10.1139/cjpp-2019-0251 Stojiljković N.; Ilić S.; Stojanović N.; Stojanović S.; Stoiljković M.; Lycopene improves methotrexate-induced functional alterations of the Madin–Darby kidney cells in a concentration-dependent manner. Can J Physiol Pharmacol 2020,98(2),111-116 J Cell Biochem Chen P. 119 366 2018 10.1002/jcb.26189 Chen P.; Xu S.; Qu J.; Lycopene Protects Keratinocytes Against U.V.B.; Lycopene protects keratinocytes against uvb radiation‐induced carcinogenesis via negative regulation of FOXO3a through the mTORC2/AKT signaling pathway. J Cell Biochem 2018,119(1),366-377 RSC Advances Bano S. 10 16637 2020 10.1039/C9RA10686C Bano S.; Ahmed F.; Khan F.; Chaudhary S.C.; Samim M.; Targeted delivery of thermoresponsive polymeric nanoparticle-encapsulated lycopene: in vitro anticancer activity and chemopreventive effect on murine skin inflammation and tumorigenesis. RSC Advances 2020,10(28),16637-16649 Nutrients Czarnik-Kwaśniak J. 12 96 2019 10.3390/nu12010096 Czarnik-Kwaśniak J.; Kwaśniak K.; Kwasek P.; Świerzowska E.; Strojewska A.; Tabarkiewicz J.; The influence of lycopene, [6]-gingerol, and silymarin on the apoptosis on U-118MG glioblastoma cells in vitro model. Nutrients 2019,12(1),96

Rights & Permissions Print Cite
Article Metrics
69
3
Wayfinder Image
Open Access Journals Promotions
© 2024 Bentham Science Publishers | Privacy Policy