Title:Intravenous Administration of Hypertonic Glucose Solution to Prevent
Dizziness in Patients Undergoing Gastrointestinal Endoscopy Under General
Anesthesia: A Randomized Clinical Trial
Volume: 26
Issue: 8
Author(s): Lei Zhang, Xue-Shan Bu, Qian-Qian Qiao, Yi-Qiang Ren, Bo Yu, Xing-Peng Xiao, Yi-Fan Jia, Zhong-Yuan Xia*, Li-Ying Zhan*Shi-Hua Yu*
Affiliation:
- Department of Anesthesiology, Renmin Hospital, Wuhan University, Wuhan, Hubei, 430071, China
- Laboratory of
Anesthesiology and Critical Care Medicine, Renmin Hospital, Wuhan University, Wuhan, Hubei, 430071, China
- Laboratory of
Anesthesiology and Critical Care Medicine, Renmin Hospital, Wuhan University, Wuhan, Hubei, 430071, China
- Department of Critical Care Medicine, Renmin Hospital, Wuhan University, Wuhan, Hubei, 430071,
China
- Department of Anesthesiology, Renmin Hospital of Hannan District, Wuhan University, Wuhan, Hubei,
430090, China
Keywords:
Hypertonic glucose, dizziness, gastrointestinal endoscopy, general anesthesia, intravenous, hyperosmotic characteristics.
Abstract:
Background and Objective: Dizziness is a common complication of gastrointestinal endoscopy
under general anesthesia. Dizziness is primarily caused by a lack of energy and blood volume
following fasting and water deprivation. Hypertonic glucose solution (HGS) is an intravenous
energy replenishment, that increases blood volume due to its hyperosmotic characteristics and can
be directly absorbed from blood circulation. This study aimed to HGS can prevent dizziness after
gastrointestinal endoscopy.
Methods: This was a double-blind, randomized, controlled study. Eligible patients were randomly
allocated into two groups based on the intravenous agent administered before gastrointestinal
endoscopy: Group A, saline (0.9%; 20 mL); and group B, HGS (50%; 20 mL). Overall, 840
patients were included in the statistical analysis. The scores and incidence of dizziness were assessed.
Results: The dizziness score were higher in group A than in group B (1.92 ± 0.08 vs. 0.92 ±
0.06; p < 0.01). The incidence of mild dizziness and moderate-to-severe dizziness was significantly
lower in group B than in group A (40.10% vs. 51.78% and 3.10% vs. 19.72%, respectively;
p < 0.01). The incidence and score of dizziness were significantly lower in males than in females
(30.81% vs. 51.82% and 0.64 ± 0.08 vs. 1.12 ± 0.08, respectively; p < 0.01) after pretreatment
with HGS.
Conclusion: Pretreatment with HGS effectively prevents dizziness after gastrointestinal endoscopy
under general anesthesia. The mechanism of action is unclear but might be related to body energy
replacement and an increase in blood volume following HGS administration.
