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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Review Article

Natural Polymers as a Carrier for the Effective Delivery of Antineoplastic Drugs

Author(s): Rajat Patel, Utkarsha Kuwar, Nidhi Dhote, Amit Alexander, Kartik Nakhate, Parag Jain and Ajazuddin*

Volume 21, Issue 2, 2024

Published on: 27 January, 2023

Page: [193 - 210] Pages: 18

DOI: 10.2174/1567201820666230112170035

Price: $65

Abstract

Cancer is a broad term for a set of disorders marked by the development of physically and functionally changed cells that proliferate uncontrollably, infect neighboring tissues, and result in malignant tumours, 'neoplasm'. Cancer remains a difficult disease to treat because of the significant adverse effects and poor pharmacokinetic profile of antineoplastic drugs, despite advancements in our understanding of the features and behavior of tumor cells in recent decades. In this series, the role of natural polymers is prominent as a component of a novel delivery system of anticancer drugs. These natural polymeric drug delivery systems (NPDDS) have many advantages over synthetic polymers like controlled delivery, biodegradability, inexpensive, low toxicity profile, and easily obtainable. These polymers further modify for the targeting of tumour cells. This review discusses and critically analyses the different natural polymers, such as chitosan, cellulose, starch, albumin, dextran, fucoidan, gelatin, etc., in terms of natural ingredient-based polymeric nanocarriers specifically for cancer therapy. It also describes benefits, drawbacks, and opinions and provides insights about the efficacy of NPDDS as well as its future perspectives and tabulated recent patents and cases under clinical trials exploited for cancer treatment.

Keywords: Natural polymer, antineoplastic drug, natural polymers, nanocarriers, targeting, cancer.

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