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摘要
胃肠道(GI)癌症是最常见的人类恶性肿瘤之一,也是世界范围内发病率和死亡率的主要原因。基因组/表观基因组学改变是癌症最显著的标志之一,也是几乎所有胃肠道恶性肿瘤的基本特征。DNA甲基化被强调为几种肿瘤抑制基因信号通路失活的基本机制。因此,DNA甲基化位点可以被触发用于癌症治疗。现有的胃肠道肿瘤治疗方法疗效不理想,一些治疗方法伴有严重的副作用,包括溃疡或出血。因此,寻找替代疗法至关重要。越来越多的证据表明,一些化学预防植物化学物质可以对抗癌症。姜黄素(CUR)是最系统研究的营养保健品之一,因为它在管理不同疾病方面具有优势。CUR以其靶向表观遗传机制的有效抗癌特性而闻名,其中DNA甲基化是最重要的。先前的研究表明,CUR治疗可以通过控制与氧化应激和表观基因组学途径相关的几种信号通路而使胃肠道癌症受益。目前的文献显示了最近关于DNA甲基化改变的证据,以及它在胃肠道癌症预防和治疗中的潜在作用。
关键词: 姜黄素,DNA甲基化,表观遗传学,胃肠道癌症,化学预防植物化学物质,嵌合抗原受体。
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