Title:Palladium-Catalyzed C-N Coupling in the Synthesis of Benzodiazepines
Volume: 26
Issue: 22
Author(s): Pooja Grewal and Navjeet Kaur*
Affiliation:
- 1Department of Chemistry, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India
- Department of Chemistry & Division of
Research and Development, Lovely Professional University, Phagwara, 144411, Punjab, India
Keywords:
1, 3-Benzodiazepines, 2, 3-benzodiazepines, 2.4-benzodiazepines, palladium, Pd(OAc)2, Pd2(dba)3, C-N coupling.
Abstract: This review article is focused on the reactions, which include the syntheses of various
classes of benzodiazepines in the presence of a Pd catalyst. The catalyst used here belongs
to the transition metal group and nowadays, there is keen interest in numerous methods for the
coupling reaction in the presence of a catalyst to prepare the biologically active heterocyclic
compounds. In particular, the use of domino reactions as inter- or intramolecular processes is
reported as an efficient and eco-compatible tool to obtain differently functionalized benzodiazepines.
2,3-benzodiazepines having pharmaceutical interest are synthesized via asymmetric
catalysis. The catalyst used in this synthesis is palladium-chiral bidentate phosphine complex
and thiazolium-derived carbine. The 1,3-benzodiazepines are prepared by A3 coupling. In this
reaction, the propargylamine was first added to the isocyanates. After that, hydroxylation of
alkyne occurs in the presence of a Pd catalyst in a one-pot manner to yield the 1,3-benzodiazepines.