Title:The Effect of Bisoprolol on Premature Ventricular Complex in Vietnamese
Patients with Hypertension and Left Ventricular Hypertrophy
Volume: 19
Issue: 1
Author(s): Son Kim Tran, Toan Hoang Ngo*, Anh Thi Phuong Nguyen, Huyen Thi Ngoc Huynh, Cuong Tan Vo, Ngan Ngoc Bao Nguyen, Thang Hoang Nguyen and Minh Van Huynh
Affiliation:
- Department of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City 900000, Vietnam
Keywords:
Premature ventricular contraction, hypertension, left ventricular hypertrophy, bisoprolol, heart rate, electrocardiogram.
Abstract:
Background: Premature ventricular contraction (PVC) is a common arrhythmia that causes a
large number of clinical symptoms, adversely impacts the quality of life, and can even initiate serious
arrhythmias, such as ventricular tachycardia or ventricular fibrillation. The incidence of premature ventricular
contraction is higher in hypertensive patients, particularly if concomitant left ventricular hypertrophy
(LVH) is present.
Objectives: This study was conducted on the characteristics of PVC in hypertensive patients with left
ventricular hypertrophy and aimed to evaluate the effect of bisoprolol on PVC in Vietnamese patients
with hypertension and LVH.
Materials and Methods: We conducted a study to determine how bisoprolol potency affected PVC
management in the group with both high blood pressure and LVH. We selected a convenient sample of
all patients who came to the Medical Examination Department at the Can Tho University of Medicine
and Pharmacy Hospital and met sampling criteria with hypertension, LVH on echocardiography, and
PVC on 12-leads electrocardiogram. Over 2 years, we collected 76 patients who satisfied the above
conditions. Out of which, 50 patients were indicated for management with bisoprolol, and 26 patients
were excluded from the study, including 7 patients with asthma and 19 patients who had simple PVC on
a 24-hour Holter ECG. Data were analyzed with SPSS version 22.
Results: Fifty patients participated in the study, of whom 70% were female. It is clear that palpitation
was the most prevalent symptom (66%), and 38% of patients had complicated PVC (Lown III-V). When
treating PVC with bisoprolol, 50% of patients achieved the treatment goal with a decrease in the number
of PVCs of more than 70%, accompanied by symptom relief and eradication of dangerous PVCs. After
4 weeks of treatment, bisoprolol decreased the number of PVCs, heart rate, and blood pressure while also
easing PVC-related symptoms (p < 0.05).
Conclusion: Low-dose bisoprolol effectively reduces the number of PVCs in hypertensive patients
with LVH.
