Title:Chemistry Characterization and Application of Nanocrystals-based Drug
Delivery System: Present to Future Perspective
Volume: 11
Issue: 3
Author(s): Manami Dhibar, Santanu Chakraborty*, Abhijeet Kundu and Payel Laha
Affiliation:
- Formulation Development Research Unit, Department of Pharmaceutics, Dr. B.C. Roy College of Pharmacy and AHS,
Durgapur-06, West Bengal, India
Keywords:
Solubility, systemic bioavailability, dissolution, nanocrystals, drug targeting solubility, drug targeting.
Abstract: With the development of new technologies, various drugs with higher efficacy have
been found, but their therapeutic use is still limited owing to poor water solubility, which leads to
poor systemic bioavailability. Currently, about 40% of newly discovered drugs have a solubility
issue. It is a major challenge for formulation scientists to overcome this problem and make a robust
and effective formulation. One such unique approach is to formulate the drug as nanocrystals
which alter the physical characteristics of the drug, resulting in the development of a novel formulation
strategy for poorly soluble drugs. Nanocrystals are produced by various techniques such as
top-down, bottom-up, or combination methods. Nanocrystals improve the clinical application of
problematic drug molecules by decreasing the particle size, enhancing the dissolution rate and
reducing the dose requirement, etc. This approach is not only improving the bioavailability of the
drug but also facilitates the drug targeting to specific sites due to its feasibility of surface modification
and all administration routes. This article deals with the various aspects of nanocrystals including
chemistry, production, stabilization, characterization, and application in the field of pharmacy.
