Title:Bioadhesive Systems Targeting Site-Specific Mucosal Delivery
Volume: 12
Issue: 3
Author(s): Shanthi Chede and Leela Raghava Jaidev Chakka*
Affiliation:
- Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, 115 S Grand Avenue, Iowa City, Iowa, 52242-1112, USA
- Division of Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, Texas, USA
Keywords:
Bioadhesion, bioadhesive polymers, buccal delivery, esophageal delivery, tissue surface, mucoadhesion.
Abstract: One of the major limitations to drug delivery at mucosal administration sites is the limited
retention of the dose at the tissue surface. Bioadhesive delivery systems increase the residence
time/retention of the dosage form at the application site. To retain the drug at the site of administration
for improved absorption and ease of administration, the identification of polymer systems
based on site-specific physiological conditions is important. This review outlines diverse kinds of
polymer systems and their mechanism of mucoadhesion. This review presents a brief description of
bioadhesive strategies for the formulation and development of a buccal and esophageal delivery system
based on its site-specific physiological considerations.