Title:Toxic, Genotoxic and Teratogenic Effects of Ibuprofen and its Derivatives
Volume: 24
Issue: 4
关键词:
布洛芬，毒性，遗传毒性，致畸性，副作用，过量，人类临床病例。
摘要:
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are extensively used
pharmaceuticals and tons of kilos are produced annually. Ibuprofen is one of the core medicines of
non-steroidal anti-inflammatory drug and is primarily used for reduced pain, fever and tissue inflammation.
It is also available for the treatment of osteoarthritis, rheumatoid arthritis, tendonitis,
etc. It is still one of the most prescribed non-steroidal anti-inflammatory drugs in contemporary
times. Although ibuprofen is a drug that has been used for years, it is also known to have various
serious toxic effects.
Objective: In this review, we aimed to clarify toxic and genotoxic effects of Ibuprofen by analyzing
major journal indexes.
Methods: The search was concentrated on the Web of Science, PubMed, Science Direct, Scopus,
EBSCO Host, and Google Scholar databases, including the keyword combinations "genotoxicity",
"toxicity", "teratogenicity", "side effects", "Ibuprofen".
Results: In the search procedure, a total number of 11738 studies about the topic were reviewed.
Consequently, 42 studies were classified as appropriate according to the inclusion criteria and were
therefore included in the review. The results presented and discussed in this review indicate that
Ibuprofen might represent a toxic, genotoxic and teratogenic risk for non-target, freshwater invertebrates,
vertebrates and toxic for human especially in overdose or misuse situation.
Conclusion: Ibuprofen generally was found to be toxic, mutagenic, teratogenic and genotoxic
agent in various organisms. In human cases mostly overdose or misuse was found to be toxic. However
acute toxicity was also reported in some human clinical studies. More detailed genotoxicity,
teratogenicity and especially carcinogenic potential should be investigated to reach full decision of
its safety.
