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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Systematic Review Article

New Strategies in the Treatment of Plasmodium berghei Based on Nanoparticles: A Systematic Review

Author(s): Pegah Shakib, Abdolrazagh Marzban, Omid Mardanshah, Shirzad Fallahi, Israr Ali Khan, Mohammad Azarhazin and Kourosh Cheraghipour*

Volume 24, Issue 11, 2023

Published on: 17 January, 2023

Page: [1376 - 1382] Pages: 7

DOI: 10.2174/1389201024666230103111833

Price: $65

Abstract

Background: Drug resistance is a current issue affecting parasites caused by Plasmodium. Therefore, researchers have expanded their studies on nanoparticles to find new and effective drugs that can treat drug-resistant strains. The present study systematically investigates the effect of different nanoparticles, including metal, polymer, and lipid nanoparticles, on Plasmodium berghei.

Methods: In this study, English-language online literature was obtained from the databases Science Direct, PubMed, Scopus, Ovid, and Cochrane to conduct a systematic review. In the search, we used the keywords: (Plasmodium Berghei) AND (Malaria) AND (Parasitemia) AND (antimalarial activity) AND (nanoparticles) AND (Solid lipid NPS) AND (Nano lipid carriers) AND (Artemether) AND (Chloroquine) AND (intraperitoneal) AND (in vivo). Initially, a total of 160 studies were retrieved from the search. After removing duplicates, 80 studies remained. After reviewing the title and abstract of each study, 45 unrelated studies were eliminated.

Results: The remaining 35 studies were thoroughly reviewed using the full texts. The final result was 21 studies that met the inclusion/exclusion criteria.

Conclusion: Using these findings, we can conclude that various nanoparticles possess antiparasitic effects that may be applied to emerging and drug-resistant parasites. Together, these findings suggest that nanostructures may be used to design antiparasitic drugs that are effective against Plasmodium berghei.

Keywords: Plasmodium berghei, nanoparticles, systematic review, parasitemia, malaria, drug-resistant strains, antimalarial activity, nano lipid carriers, intraperitoneal, chloroquine.

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