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Current Green Chemistry

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ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

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Mini-Review Article

Citric Acid Promoted Green Synthesis of Bioactive Heterocycles

Author(s): Yogesh Baburao Wagh, Yogesh Ashok Tayade, Pramod Pandurang Mahulikar and Dipak Sharadrao Dalal*

Volume 10, Issue 1, 2023

Published on: 15 February, 2023

Page: [73 - 91] Pages: 19

DOI: 10.2174/2213346110666230102120527

Price: $65

Open Access Journals Promotions 2
Abstract

In this review, we report green transformations of biologically active heterocycles catalyzed by Citric acid. Citric acid is found naturally in citrus fruits, especially lemons and limes. Citric acid is soluble in water used as a highly efficient and biodegradable catalyst for multi-component transformations, biomimetic reactions, and C-C bond formation. It has been applicable for the multicomponent synthesis of pyrano[2, 3-e]pyrimidin, pyrano[2, 3-d]pyrazol-amines, amidoalkyl naphthols, tetrahydropyridines, indazolo[ 2,1-b]phthalazine-triones, indazolo[2,1-b]phthalazine-triones, indazolo[2,1-b]phthalazine-triones, ethyl 3-methyl-4,5-dioxo-1,2-diphenylpyrrolidine-3-carboxylate and 2,4-disubstituted thiazoles from ketones via C-Br, C-S, and C-N Bond Formations. Citric acid is also used in combination with ultrasound for the synthesis of biologically active pyrazolyl-bis coumarinyl methanes and pyrrolidinone. Citric acid is used in the generation of nanocatalysts, mesoporous carbon materials (OMCs) as well as polymerization reactions by the reaction of resorcinol/formaldehyde resin. Citric acid is also used in the generation of fluorescent 1,4-disubstituted-1,2,3-triazoles1,8-dioxo-decahydroacridines by Hantzsch condensation.

Keywords: Citric acid, green chemistry, organic transformations, catalysis, environmentally friendly, multi-component reaction.

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