Title:Bioinformatics Paradigms in Drug Discovery and Drug Development
Volume: 23
Issue: 7
Author(s): Ravinder Sharma, Gunpreet Kaur, Parveen Bansal, Viney Chawla and Vikas Gupta*
Affiliation:
- University Centre of Excellence in Research, Baba Farid University
of Health Sciences, Faridkot, 151203, India
Keywords:
Bioinformatics, Drug design, Drug target, Genomics, Proteomics, Molecular docking.
Abstract: Despite breakthroughs in medical sciences, drug development remains a timeconsuming,
expensive, challenging, and inefficient process with a high failure rate for novel therapeutic
discoveries. Bioinformatics analysis can speed up drug target identification, drug candidate
screening, and refining, but it can also help characterise adverse effects and anticipate drug resistance.
Integrated genomics, proteomics, and bioinformatics have resulted in potent new tactics
for resolving numerous biochemical problems and establishing new methodologies that result in
new biomedical products. As a result, a new research trend emerged to demonstrate the mechanism
of therapeutic action, forecast drug resistance, and uncover biomarkers for various disorders. The
development of new medications is a complicated procedure. There are two basic approaches to
drug design: ligand-based drug design and structure-based drug design. The study of protein structure
and function was essential for drug development. Current techniques based on combinatorial
approaches such as proteomics, genomics, bioinformatics, molecular docking, and mass spectrometry
were applied. This article provides an overview of the combinatorial techniques of proteomics,
genomics, and bioinformatics that aid in understanding the drug-creation process.