Title:Efficacious Restoration of Intractable Trauma by Administration of
Mesenchymal Stem/Stromal Cells and Hydrogel Composite: A Case Series
Volume: 3
Issue: 2
Author(s): Leisheng Zhang*Zhongchao Han
Affiliation:
- Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC
Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, 730000,
China
- Key Laboratory of Radiation Technology and Biophysics, Hefei Institute of Physical Science, Chinese Academy
of Sciences, Hefei, 230031, China
- Jiangxi Research Center of Stem Cell Engineering, Jiangxi Health-Biotech Stem
Cell Technology Co., Ltd., Shangrao, 334000, China
- Institute of Stem Cells, Health-Biotech (Tianjin) Stem Cell Research
Institute Co., Ltd., Tianjin, 301700, China
Keywords:
Placenta-derived MSCs, hyaluronic acid, intractable trauma, cutaneous ulcer, efficacious remission, case series.
Abstract:
Background and Objectives: Patients with intractable cutaneous injuries and complications
such as severe ulcers and dysfunctions often result in unfavorable prognosis and burdensome
possessions esthetically and psychosocially. This study aimed to evaluate the preliminary safety
and efficacy outcomes of hyaluronic acid/placenta-derived mesenchymal stem/stromal cells
(HA/P-MSCs) composite upon extensive traumas.
Methods: The phase Ⅰ of the interventional study with four enrolled patients with refractory
wounds and ulcerations was conducted. With the consent of the patients and approval of the ethics
committee, continuous HA/P-MSC composite administration was conducted on the surface of
wounds after surgical debridement. The dynamic changes in pathomorphology and therapeutic response
were collectively recorded.
Results: All the participants revealed efficacious remission with clinical-grade HA/P-MSC composite,
including complete wound healing, elimination of inflammatory exudate and refractory ulcers,
and regeneration of damaged tissues under sterile conditions. No untoward effects or recurrence
were observed in the cases during treatment and the 24-month’s follow-up visit.
Conclusion: Refractory wound management with HA/P-MSC composite was preliminarily safe
and effective for the improvement of the outcomes of the patients. These findings provided new references
for the treatment of the costliest and incurable diseases associated with cutaneous injuries.
